The microplastics exposure induce the kidney injury in mice revealed by RNA-seq

Xiong, Xi; Gao, Likun; Chen, Chen; Zhu, Kai; Luo, Pengfei; Li, Lili

doi:10.1016/j.ecoenv.2023.114821

Cited by 23 publications

(12 citation statements)

References 35 publications

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“…In our previous study, exposure to low doses of MPs (1 mg/L) resulted in renal tissue damage and a correlation with the particle size of MPs: induce an inflammatory response, oxidative stress, and cell apoptosis in the kidney, which ultimately promotes kidney fibrosis. 10 The results are basically consistent with other existing studies on the negative effects of MPs on the kidneys, suggesting that MPs have negative effects on the kidneys, which can lead to acute and chronic kidney injury. In this study, we further established the IR model by using long-term MPs-exposed mice to study whether MPs exposure further aggravates the renal injury in the IR model.…”

Section: Discussionsupporting

confidence: 91%

“…Therefore, understanding the damage mechanism of MPs to the kidney and its impact on renal fibrosis is of great significance to public health and environmental protection. In our previous study, exposure to low doses of MPs (1 mg/L) resulted in renal tissue damage and a correlation with the particle size of MPs: induce an inflammatory response, oxidative stress, and cell apoptosis in the kidney, which ultimately promotes kidney fibrosis 10 . The results are basically consistent with other existing studies on the negative effects of MPs on the kidneys, suggesting that MPs have negative effects on the kidneys, which can lead to acute and chronic kidney injury.…”

Section: Discussionmentioning

confidence: 96%

“…In a mouse model, exposure to MPs resulted in glomerular structural damage and activation of inflammatory and oxidative stress, leading to nephrotoxicity in mice 9 . Chronic exposure to MPs in mice was found to impair kidney function by leading to increased renal fibrosis 10 . Epidemiological studies suggest that exposure to MPs may increase the risk of chronic kidney disease (CKD) in humans 11 .…”

Section: Introductionmentioning

confidence: 99%

“…9 Chronic exposure to MPs in mice was found to impair kidney function by leading to increased renal fibrosis. 10 Epidemiological studies suggest that exposure to MPs may increase the risk of chronic kidney disease (CKD) in humans. 11 Acute kidney injury (AKI) is a severe syndrome with an incidence of 10%-15% of hospitalized patients, mainly caused by renal ischemiareperfusion (IR) injury.…”

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confidence: 99%

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Toxicological effects of microplastics in renal ischemia–reperfusion injury

Kuang,

Gao,

Feng

et al. 2023

Environmental Toxicology

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The widespread presence of microplastics (MPs) in the environment poses a significant threat to biological survival and human health. However, our understanding of the toxic effects of MPs on the kidneys remains limited. This study aimed to investigate the underlying mechanism of the toxic effects of MPs on the kidneys using an ischemia–reperfusion (IR) mouse model. Four‐week‐old ICR mice were exposed to 0.5 μm MPs for 12 weeks prior to IR injury. The results showed that MPs exposure could aggravate the IR‐induced damage to renal tubules and glomeruli. Although there were no significant changes in blood urea nitrogen and serum creatinine levels 7 days after IR, MPs treatment resulted in a slight increase in both parameters. In addition, the expression levels of inflammatory factors (MCP‐1 and IL‐6) at the mRNA level, as well as macrophage markers (CD68 and F4/80), were significantly higher in the MPs + IR group than in the Sham group after IR. Furthermore, MPs exposure exacerbated IR‐induced renal fibrosis. Importantly, the expression of pyroptosis‐related genes, including NLRP3, ASC, GSDMD, cleaved caspase‐1, and IL‐18, was significantly upregulated by MPs, indicating that MPs exacerbate pyroptosis in the context of renal IR. In conclusion, our findings suggest that MPs exposure can aggravate renal IR‐induced pyroptosis by activating NLRP3‐GSDMD signaling.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Toxicological effects of microplastics in renal ischemia–reperfusion injury

Kuang,

Gao,

Feng

et al. 2023

Environmental Toxicology

Self Cite

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“…The entry of NPs into the body can result in a variety of adverse health effects, primarily including the induction of intracellular oxidative stress, genotoxicity, inflammatory responses, and reproductive toxicity . Notably, the liver, kidney, and brain are the ultimate target organs of NPs . In particular, the liver plays a crucial role in glycolipid metabolism .…”

Section: Introductionmentioning

confidence: 99%

Airborne Nanoplastics Exposure Inducing Irreversible Glucose Increase and Complete Hepatic Insulin Resistance

Yang,

Dong,

Gao

et al. 2024

Environ. Sci. Technol.

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As an emerging type of pollutant, microplastics have become a global environmental problem. Approximately, a fifth of the global burden of type 2 diabetes can be attributed to air particulate pollution. However, scientific knowledge remains limited about the effects of airborne nanoplastics (NPs) exposure on metabolic diseases. In this experiment, a whole-body exposure system was used to simulate the real atmospheric environment, and three exposure concentrations combined with the actual environmental concentration were selected to explore the effects of airborne NPs on metabolic diseases. Based on histological analyses, metabolic studies, gene expression, metabolites, and molecular signaling analyses, mice exposed to airborne NPs were observed to show a phenotype of systemic inflammation and complete insulin resistance featuring excessive drinking and eating, weight loss, elevated blood glucose, and decreased triglyceride levels. After airborne NPs exposure, mice were intolerant to glucose and tolerant to insulin. In addition, airborne NPs exposure could result in long-term irreversible hyperglycemia. Together, the research findings provide a strong basis for understanding the hazards of airborne nanopollution on metabolic disorders.

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