The micronutrient supplements, zinc sulphate and folic acid, did not ameliorate sperm functional parameters in oligoasthenoteratozoospermic men

Raigani, Mozhgan; Yaghmaei, Bahareh; Amirjannti, N.; Lakpour, Niknam; Akhondi, Mohammad Mehdi; Zeraati, Hojjat; Hajihosseinal, M.; Sadeghi, Mohammad Reza

doi:10.1111/and.12180

Cited by 73 publications

(83 citation statements)

References 22 publications

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“…Dietary antioxidants may be beneficial in reducing sperm DNA damage, particularly, in men with high levels of DNA fragmentation [5]. Five out of 32 studies confirmed that the usage of different antioxidants had important influence on DNA fragmentation and chromatin integrity [20, 42–46]. Song et al showed that combination of Chinese medicine Compound Xuanju Capsule with vitamin E taken for 3 months decreased degree of DNA fragmentation index (DFI) after therapy to 29.57 ± 12.19 compared just to vitamin E with degree of DFI of 34.09 ± 10.32 ( P < 0.05) [42].…”

Section: Resultsmentioning

confidence: 99%

Review of Clinical Trials on Effects of Oral Antioxidants on Basic Semen and Other Parameters in Idiopathic Oligoasthenoteratozoospermia

Kumalic

Pinter

2014

BioMed Research International

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Infertility affects 50 to 80 million people worldwide. Male factor is a cause of infertility in almost half of cases, mainly due to oligoasthenoteratozoospermia (OAT). With common diagnostic methods no cause can be found in approximately 30% of cases of male infertility due to OAT and these are considered idiopathic. Reactive oxygen species (ROS) play an important role in male infertility and are proved to be higher in infertile men; antioxidants could oppose their effect. The aim of this paper was to review the literature on clinical trials in the period from year 2000 to year 2013 studying the effects of various types of antioxidant supplements on basic and other sperm parameters and pregnancy rates in subfertile males with idiopathic OAT. The majority of studies were randomized and placebo controlled and confirmed beneficial effect of antioxidants on at least one of the semen parameters; the biggest effect was determined on sperm motility. In many of these trials combinations of more antioxidants were assessed. The optimal dosages of one or more antioxidants were not defined. We concluded that antioxidants play an important role in protecting semen from ROS and can improve basic sperm parameters in case of idiopathic OAT.

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Section: Resultsmentioning

confidence: 99%

Review of Clinical Trials on Effects of Oral Antioxidants on Basic Semen and Other Parameters in Idiopathic Oligoasthenoteratozoospermia

Kumalic

Pinter

2014

BioMed Research International

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“…Nevertheless, there is a dearth of data about the role of Zn in both human seminal plasma and serum regarding sperm' capacity for fertilization (Zhao et al, ). In men, Zn plays an important role in normal testicular development, increased sperm concentration and sperm motility (Khan, Zaman, Sajjad, Shoaib, & Gilani, ; Raigani et al, ). Besides, Zn is associated with decreased oxidative stress and improved spermatogenesis (Gabrielsen & Tanrikut, ).…”

Section: Discussionmentioning

confidence: 99%

“…The high seminal plasma concentration of Zn could play several roles in the stability of sperm membranes (Chvapil, 1973) and the stability of sperm chromatin (Björndahl & Kvist, 2010) 2016). In men, Zn plays an important role in normal testicular development, increased sperm concentration and sperm motility (Khan, Zaman, Sajjad, Shoaib, & Gilani, 2011;Raigani et al, 2014). Besides, Zn is associated with decreased oxidative stress and improved spermatogenesis (Gabrielsen & Tanrikut, 2016).…”

Section: Discussionmentioning

confidence: 99%

The relationship between seminal plasma and serum trace elements and semen parameters of dromedary camels (Camelus dromedarius)

Waheed

Meligy

Dhalam³

2018

Reprod Domestic Animals

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A total of 14 camels of known fertility (controls) at the Camel Research Centre, King Faisal University and 41 infertile dromedaries brought to the Veterinary Teaching Hospital were used in this study during the breeding season. Seminal plasma and serum were obtained from all males, and stored at -80°C until analysis. Concentrations of six trace elements (manganese [Mn], zinc [Zn], iron [Fe], selenium [Se], copper [Cu] and chromium [Cr]) were estimated in the seminal plasma and serum using an atomic absorption spectrophotometer. Results showed significant (p < 0.05 and p < 0.01) differences in semen pH and sperm motility, concentration and abnormalities between the control and infertile dromedaries. In seminal plasma, a significant (p < 0.01) difference in Fe concentrations (7.792 ± 1.567 vs. 61.259 ± 11.967 mg/L) and significant (p < 0.05) differences in Zn (24.763 ± 8.206 vs. 83.981 ± 4.972 mg/L) and Cu (1.653 ± 0.348 vs. 7.905 ± 1.134 mg/L) concentrations existed between the control and infertile dromedaries, respectively. In serum, there were significant (p < 0.05) differences in Fe (6.237 ± 0.695 vs. 151.121 ± 27.604 mg/L) and Cu (24.703 ± 4.195 vs. 6.375 ± 0.644 mg/L) concentrations and a significant (p < 0.01) difference in Zn concentrations (17.086 ± 1.606 vs. 90.422 ± 4.347 mg/L) between the fertile and infertile camels, respectively. There were significant (p < 0.05) positive (r = 0.51) and negative (r = -0.54) correlations between Zn concentrations in seminal plasma and both sperm motility and sperm abnormalities, respectively. In conclusion, seminal plasma and serum trace elements of Fe, Zn and Cu influenced the semen parameters and fertility of dromedary camels. Low concentrations of Fe, Zn and Cu in the seminal plasma were associated with normal fertility in dromedaries.

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“…Several researches confirm the repairing and maintenance role of FA during oxidative stress 32 . However, Raigani reported FA supplementation did not ameliorate sperm quality in infertile men 28 . The FA successfully alleviated the SOD, GPx depletion and MDA elevation 29 .…”

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confidence: 94%

Effects of folic acid administration on testicular ischemia/reperfusion injury in rats

et al. 2017

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1 8-Experimental SurgeryActa Cir Bras. 2017;32(9):755-766 Abstract Purpose: To determine the effect of folic acid (FA) on experimental testicular ischemia/reperfusion (I/R) in rats. Methods: Sixty male Wistar rats were randomly divided into 6 groups. The control group received physiologic saline orally. The sham-operated group received physiologic saline orally then exposed to midline laparotomy without clamping the IR. The I/R rats received oral gavage of the saline then subjected to 1h ischemia /24h reperfusion, period. In folic acid (2mg/ kg+IR) rats received oral gavage of the FA (2mg/kg) then subjected to 1h I/24h R. groups 5-6 received FA (5 and 10 mg/kg), then subjected to 1 h I/24 h, respectively. At the end of the study, semen samples were collected for spermatozoa characteristics. The left testis was removed for histological analysis and superoxide dismutase (SOD), malondialdehyde (MDA) and glutathione peroxidase (GPx) measurement. Results: Spermatozoa mobility, mortality (%) significantly decreased in I/R group (P<0.05). Dose dependent increase observed on spermatozoa mobility, mortality (%) using different levels of the FA (2, 5 and 10 mg/kg) treated rat (P<0.05). Tissue MDA levels significantly increased in I/R rat (P<0.05) while FA (2, 5 and 10mg/kg) in a dose dependent manner decreased I/R-induced MDA (P<0.05). Experimental I/R significantly decreased SOD and GPx activity (P<0.05). Administration of the FA (2, 5 and 10mg/kg) significantly increased tissue SOD and GPx activity in I/R rat (P<0.05). Seminiferous tubules degenerated and loss of spermatogenesis with few spermatocytes was observed in degenerated testis tubules in I/R rat. Orally administration of the FA (5 and 10 mg/kg) improved testis characteristics with few normal seminiferous tubules and spermatocyte in seminiferous tubules in experimental I/Rinduced rat. Conclusion:The treatment of folic acid had a benefit effect against ischemia-reperfusion.

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The micronutrient supplements, zinc sulphate and folic acid, did not ameliorate sperm functional parameters in oligoasthenoteratozoospermic men

Cited by 73 publications

References 22 publications

Review of Clinical Trials on Effects of Oral Antioxidants on Basic Semen and Other Parameters in Idiopathic Oligoasthenoteratozoospermia

Review of Clinical Trials on Effects of Oral Antioxidants on Basic Semen and Other Parameters in Idiopathic Oligoasthenoteratozoospermia

The relationship between seminal plasma and serum trace elements and semen parameters of dromedary camels (Camelus dromedarius)

Effects of folic acid administration on testicular ischemia/reperfusion injury in rats

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