The microgravity applications promotion programme of the European Space Agency, ESA

Walter, H. U.; Binot, Roger A.; Kufner, E.; Minster, Olivier

doi:10.1063/1.54825

Cited by 1 publication

(2 citation statements)

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“…Apart from their usual intervention in biological systems regulation, reproduction and maintenance mechanisms of living organisms, they act as catalysts and carryout other biological functions. Contrarily, they are also the cause of some diseases and disorders 1 . This knowledge has been employed by pharmaceutical companies to develop novel drugs that target only affected macromolecule and inhibit the active site of macromolecules with the knowledge of their threedimensional (3D) structure 2 .…”

Section: Introductionmentioning

confidence: 99%

“…With detailed knowledge of the 3D structure of biological macromolecules biochemists and biological scientists are able to restrict the choice of drugs to be tested, this also enable scientist to synthesize drug like monoclonal antibodies (MABs) that target solely a particular macromolecule using a lucid drug method strategy. This implies that a drug is able to bind effectively to the macromolecule inhibiting its biological role without having any effect on other macromolecules 1 . Often the immune system is combated by some diseasecausing substances resulting in ailments.…”

Section: Introductionmentioning

confidence: 99%

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Microgravity: A Tool for Protein Drug Development

Enemali¹,

Oluwafemi²,

Hussaini³

et al. 2020

IJPSRR

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For the past two decades diverse technological advancement in X-ray crystallography have resulted in faster determination of structures of large macromolecules especially proteins. Although the capacity to produce diffraction-quality crystals suitable for exhaustive structural analysis remains a bottleneck, even with the combined automated technology cum site directed mutagenesis. Research in the crystallization of protein in microgravity promises to proffer solution to some of the grey areas as crystals of better quality are produced in the microgravity compared to the Earth's environment. This is used extensively in drug development especially monoclonal antibodies (MABs); and in other applications has been acknowledged by some group of scientists and those of the International Space Station (ISS). This paper recapitulates the account of some of the work done by these scientists on protein crystals yielded in microgravity and the application of the crystals in MABs drug development and other important areas.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%