The microevolutionary response to male-limited X-chromosome evolution in<i>Drosophila melanogaster</i>reflects macroevolutionary patterns

Abbott, Jessica K.; Chippindale, Adam K.; Morrow, Edward H.

doi:10.1101/800672

Cited by 4 publications

(4 citation statements)

References 71 publications

(121 reference statements)

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“…4B), which is not consistent with previous results showing that locomotory activity is a sexually antagonistic trait (Long and Rice 2007; Abbott et al. 2020).…”

Section: Resultscontrasting

confidence: 86%

“…Abbott et al. (2020) showed that after ∼30 generations of an MLX evolution experiment, the locomotory activity of MLX females had increased to levels comparable to that of males. We did find that FLX females were less active than FLX males, but there was no evidence that FLX males had decreased locomotion activity compared to the other regimes.…”

Section: Discussionmentioning

confidence: 99%

“…For example, a similar male‐limited X chromosome evolution experiment did not find changes in female fitness (only in male fitness) when selecting on the X chromosome (Abbott et al. 2020) and a recent GWAS (Genome‐Wide Association Study) study using the same base population did not find any evidence for enrichment on the X chromosome of sexually antagonistic variance for fitness (Ruzicka et al. 2019).…”

Section: Discussionmentioning

confidence: 99%

“…2013, Abbott et al. 2020) or the removal or limitation of sexual selection investigating interlocus conflict (Holland and Rice 1999; Pitnick et al. 2001; Morrow et al.…”

mentioning

confidence: 99%

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Feminization of complex traits inDrosophila melanogastervia female‐limited X chromosome evolution*

2020

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A handful of studies have investigated sexually antagonistic constraints on achieving sex-specific fitness optima, although exclusively through male-genome-limited evolution experiments. In this article, we established a female-limited X chromosome evolution experiment, where we used an X chromosome balancer to enforce the inheritance of the X through the matriline, thus removing exposure to male selective constraints. This approach eliminates the effects of sexually antagonistic selection on the X chromosome, permitting evolution toward a single sex-specific optimum. After multiple generations of selection, we found strong evidence that body size and development time had moved toward a female-specific optimum, whereas reproductive fitness and locomotion activity remained unchanged. The changes in body size and development time are consistent with previous results, and suggest that the X chromosome is enriched for sexually antagonistic genetic variation controlling these particular traits. The lack of change in reproductive fitness and locomotion activity could be due to a number of mutually nonexclusive explanations, including a lack of sexually antagonistic variance on the X chromosome for those traits or confounding effects of the use of the balancer chromosome. This study is the first to employ female-genome-limited selection and adds to the understanding of the complexity of sexually antagonistic genetic variation.

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“…4B), which is not consistent with previous results showing that locomotory activity is a sexually antagonistic trait (Long and Rice 2007; Abbott et al. 2020).…”

Section: Resultscontrasting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…2013, Abbott et al. 2020) or the removal or limitation of sexual selection investigating interlocus conflict (Holland and Rice 1999; Pitnick et al. 2001; Morrow et al.…”

mentioning

confidence: 99%

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Feminization of complex traits inDrosophila melanogastervia female‐limited X chromosome evolution*

2020

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Feminisation of complex traits inDrosophila melanogastervia female-limited X chromosome evolution

Lund-Hansen

Abbott

Morrow

2020

Preprint

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1A handful of studies have investigated sexually antagonistic constraints on obtaining 2 sex-specific fitness optima, though exclusively through male-genome-limited 3 evolution experiments. In this paper, we established a female-limited X chromosome 4 evolution experiment, where we used an X chromosome balancer to enforce the 5 inheritance of the X chromosome through the matriline, thus removing exposure to 6 male selective constraints. This approach eliminates the effects of sexually 7 antagonistic selection on the X chromosome, permitting evolution towards a single 8 sex-specific optimum. After multiple generations of selection, we found strong 9 evidence that body size and development time had moved towards a female-specific 10 optimum, whereas reproductive fitness and locomotion activity remained unchanged. 11The changes in body size and development time are consistent with previous results, 12 and suggest that the X chromosome is enriched for sexually antagonistic genetic 13 variation controlling these traits. The lack of change in reproductive fitness and 14 locomotion activity could be due to a number of mutually non-exclusive explanations, 15 including a lack of sexually antagonistic variance on the X chromosome or 16 confounding effects of the use of the balancer chromosome. This study is the first to 17 employ female-genome-limited selection and adds to the understanding of the 18 complexity of sexually antagonistic genetic variation. 19 20 21

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Evolutionary genetics ofDrosophila melanogasterimmunity: role of the X chromosome and sex-specific dominance

Arun

Agarwala

Jigisha

et al. 2020

Preprint

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Intralocus Sexual Conflict (IaSC) ensues when males and females of the same species experience divergent selection on shared traits. A large number of traits have been implicated in IaSC and there is growing evidence for sexual antagonism associated with immunity. X chromosomes are thought to be hotspots of sexually antagonistic genetic variation and have been shown to harbour substantial immunity-related genetic variation.Here, using interpopulation crosses and cytogenetic cloning, we investigated the role of the X chromosome in improved immune response of laboratory populations of the fruit-fly Drosophila melanogaster selected against systemic infection by Pseudomonas entomophila.We could not detect any contribution of the X chromosome in the evolved immune response of our selected populations. However, we found strong evidence of sex-specific dominance related to immunity in our populations. Our results indicate that alleles that confer a superior immune response to the selected populations are, on average, partially dominant in females but partially recessive in males.We argue that sex-specific dominance over immunity evolved as a by-product of sexually antagonistic selection in the wild ancestors of our populations. We also highlight sex-specific dominance as a potential mechanism of sex differences in immunity, with population-level sex differences primarily driven by sex differences in heterozygotes.

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The microevolutionary response to male-limited X-chromosome evolution inDrosophila melanogasterreflects macroevolutionary patterns

Cited by 4 publications

References 71 publications

Feminization of complex traits inDrosophila melanogastervia female‐limited X chromosome evolution*

Feminization of complex traits inDrosophila melanogastervia female‐limited X chromosome evolution*

Feminisation of complex traits inDrosophila melanogastervia female-limited X chromosome evolution

Evolutionary genetics ofDrosophila melanogasterimmunity: role of the X chromosome and sex-specific dominance

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