The Microenvironment of Tongue Cancer

Tao, Want; Zeng, Lingyong; Li, Kan; Li, Jinyuan; Liu, Xiangqi; Liang, Yujie

doi:10.1007/978-3-030-59038-3_4

Cited by 2 publications

(1 citation statement)

References 253 publications

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“…It can be divided into squamous cell carcinoma and adenocarcinoma according to pathological classification, and squamous epithelial cell carcinoma is the most common [ 2 ]. There are many causes of oral cancer, such as long-term alcohol consumption, smoking, lack of attention to oral hygiene, and long-term areca nut chewing that can lead to oral cancer [ 3 , 4 ]. Gas, alcohol, and other components produced during smoking will stimulate the mucosa, leading to normal oral mucosal injury or even mutation.…”

Section: Introductionmentioning

confidence: 99%

The Relationship between VEGF-C, TAM, and Lymph Node Metastasis in Oral Cancer

Wang

Tan

Liu

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Objective. To investigate the relationship between vascular endothelial growth factor-C (VEGF-C) and tumor-associated macrophages in oral cancer (TAMs) with lymph node metastasis. Method. From January 2018 to January 2022, 155 cases of oral cancer tissues and 165 cases of normal mucosal tissues were collected from oral surgical resection tissues or biopsy specimens in Hebei Eye Hospital. Oral cancer tissues were observed. The control group had normal mucosal tissues. The clinical and immune parameters were observed and the treatment of oral cancer is also briefly discussed. Results. The number of TAMs and the expression of VEGF-C in oral cancer tissues were significantly higher than those in normal tissues ( P < 0.05 ). The lymphatic vessel density, the number of TAMs, and the expression of VEGF-C in the metastatic group were higher than in nonmetastatic group, and the lymphatic vessel density, the number of TAMs, and the expression of VEGF-C in the paracancerous tissues were higher than central tumor tissue in the metastatic group ( P < 0.05 ). Univariate analysis showed that the number of TAMs was related to the histological stage and the pathological type of oral cancer ( P > 0.05 ). The expression of VEGF-C was associated with the histological stage of oral cancer ( P < 0.05 ). Compared with the immune function after different treatments, the contents of CD4+ in both groups was higher than before, and the combined treatment group was increased more than single treatment group ( P < 0.05 ). The contents of CD3+ and CD8+ in the two groups were lower than before, and the combined treatment group was decreased higher than combined treatment group ( P < 0.05 ). Conclusions. The number of TAMs and the expression of VEGF-C in oral cancer tissues are higher than normal tissues. The number of TAMs and the expression of VEGF-C are higher in patients with lymph node metastasis. TAMs and VEGF-C may play an important role in lymph node metastasis of oral cancer. Integrated traditional Chinese and Western medicine can improve the immune function of patients with oral cancer and may improve the therapeutic efficacy.

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Section: Introductionmentioning

confidence: 99%

The Relationship between VEGF-C, TAM, and Lymph Node Metastasis in Oral Cancer

Wang

Tan

Liu

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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SCUBE3 Exerts a Tumor-Promoting Effect in Tongue Squamous Cell Carcinoma by Promoting CEBPA Binding to the CCL2 Promoter

Zhu,

Ma,

Wang

et al. 2024

Molecular Cancer Research

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Tongue squamous cell carcinoma (TSCC) is the main pathological subtype of oral cancer, and the current therapeutic effect is far from satisfactory. The signal peptide-CUB-EGF domain-containing protein 3 (SCUBE3) has been shown to be a tumor-promoting factor in several malignancies. However, little is known about the role of SCUBE3 in TSCC. In this study, we identified that SCUBE3 was highly expressed in TSCC. Clinically, high expression of SCUBE3 was positively associated with tumor stage and T stage of TSCC. Functionally, SCUBE3 silence remarkably restrained cell proliferation, migration and invasion, induced apoptosis as well as cell cycle arrest in G2 phase, and weakened the tumorigenicity of TSCC cells in vivo. Mechanistically, SCUBE3 promoted the direct binding of CCAAT enhancer binding protein alpha (CEBPA) to C-C motif chemokine ligand 2 (CCL2) promoter in TSCC cells. Interestingly, CCL2 overexpression partially reversed the inhibitory effect of SCUBE3 deficiency on TSCC cell viability and migration. Moreover, signal transducer and activator of transcription 3 (STAT3) signaling contributed to CCL2-mediated phenotypes in TSCC cells. Implications: our data revealed a tumor-promoting role for SCUBE3 in TSCC via the CEBPA/ CCL2/STAT3 axis, which provided new insight into novel potential therapeutic target for TSCC.

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The Microenvironment of Tongue Cancer

Cited by 2 publications

References 253 publications

The Relationship between VEGF-C, TAM, and Lymph Node Metastasis in Oral Cancer

The Relationship between VEGF-C, TAM, and Lymph Node Metastasis in Oral Cancer

SCUBE3 Exerts a Tumor-Promoting Effect in Tongue Squamous Cell Carcinoma by Promoting CEBPA Binding to the CCL2 Promoter

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