The microenvironment of the atheroma expresses phenotypes of plaque instability

Yan, Angela; Gotlieb, Avrum I.

doi:10.1016/j.carpath.2023.107572

Cited by 4 publications

(2 citation statements)

References 141 publications

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“…Additionally, MCT transporters in endothelial cell membranes cause the uptake of lactate into these cells, which inactivates prolyl hydroxylase and stabilizes hypoxia-inducible factor-1α (HIF-1α); this promotes the ingrowth of blood vessels from the vasa vasorum in the adventitia and media of the artery into the plaque, making them more likely to rupture due to weakening of the cap [19,20]. Moreover, the additional blood vessels provide extra nutrients and oxygen, which support plaque progression and increase the likelihood of intraplaque hemorrhage [21]. Many factors contribute to plaque neovascularization, plaque instability, and plaque rupture, e.g., necrotic core expansion, the secretion of adipokines and cytokines from cells of the arterial wall, and augmented inflammation [22].…”

Section: Altered Plaque Metabolismmentioning

confidence: 99%

Mitochondrial Melatonin: Beneficial Effects in Protecting against Heart Failure

Reiter,

Sharma,

Chuffa

et al. 2024

Life

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Cardiovascular disease is the cause of physical infirmity and thousands of deaths annually. Typically, during heart failure, cardiomyocyte mitochondria falter in terms of energy production and metabolic processing. Additionally, inflammation and the accumulation of non-contractile fibrous tissue contribute to cardiac malfunction. Melatonin, an endogenously produced molecule, experimentally reduces the initiation and progression of atherosclerotic lesions, which are often the basis of coronary artery disease. The current review critically analyzes published data related to the experimental use of melatonin to forestall coronary artery pathologies. Collectively, these studies document melatonin’s anti-atherosclerotic actions in reducing LDL oxidation and triglyceride levels, lowering endothelial malfunction, limiting adhesion molecule formation, preventing macrophage polarization to the M1 pro-inflammatory phenotype, changing cellular metabolism, scavenging destructive reactive oxygen species, preventing the proliferation and invasion of arterial smooth muscle cells into the lesioned area, restricting the ingrowth of blood vessels from the vasa vasorum, and solidifying the plaque cap to reduce the chance of its rupture. Diabetic hyperglycemia, which aggravates atherosclerotic plaque formation, is also inhibited by melatonin supplementation in experimental animals. The potential value of non-toxic melatonin as a possible inhibitor of cardiac pathology in humans should be seriously considered by performing clinical trials using this multifunctional molecule.

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Section: Altered Plaque Metabolismmentioning

confidence: 99%

Mitochondrial Melatonin: Beneficial Effects in Protecting against Heart Failure

Reiter,

Sharma,

Chuffa

et al. 2024

Life

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“…Acute coronary syndrome (ACS) is an acute ischemic syndrome of the heart caused by thrombosis due to rupture or erosion of unstable atheromatous plaques in the coronary arteries. [ 1 – 3 ] It is more common in western countries such as Europe and the United States, with a higher incidence in men than in women, and is also a major cause of death in people. [ 3 , 4 ] Approximately 19 million people died from cardiovascular disease worldwide in 2020, an increase of 18.7% compared to 2010.…”

Section: Introductionmentioning

confidence: 99%

The research progress and research trends in acute coronary syndrome nursing: A review of visual analysis based on the Web of Science database

Liu,

Li,

Mei

et al. 2024

Medicine

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Acute coronary syndrome (ACS) is one of the most common and severe forms of cardiovascular disease and has attracted worldwide attention with increased morbidity and mortality in recent years. There are few review studies in the field of its care in the form of bibliometric studies. We searched the Web of Science Core Collection database for articles and reviews in the area of ACS nursing for visual mapping analysis. Our objectives are to explore the hot topics and frontiers of research in the field of ACS nursing and to identify collaborative relationships between countries, institutions, and authors. This study will provide researchers with intuitive reference data for future in-depth studies of ACSs.

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