The Microcirculation and Hypertension

Struijker‐Boudier, Harry A.J.; Heijnen, Bart F.J.

doi:10.1007/978-88-470-2601-8_17

Cited by 35 publications

(6 citation statements)

References 65 publications

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“…Thiazide diuretics represent a class of pharmacological agents widely used for the treatment of hypertension, which exert their action by promoting sodium chloride (and osmotically obligated water) excretion in different segments of nephron . They have been the first well-tolerated antihypertensive drugs that significantly reduced cardiovascular disease morbidity and mortality in placebo-controlled clinical studies, − and still represent an important therapeutic option in patients with cardiovascular diseases, but also for those suffering type II diabetes, obesity, and related metabolic complications. ,− …”

Section: Insights Into Ca Inhibition: Structural Features Of Zinc Bin...mentioning

confidence: 99%

Multiple Binding Modes of Inhibitors to Carbonic Anhydrases: How to Design Specific Drugs Targeting 15 Different Isoforms?

et al. 2012

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CAs 4423 3. Insights into CA Catalytic Mechanism: CO 2 and HCO 3 − Binding to hCA II 4423 4. Insights into CA Inhibition: Structural Features of Zinc Binding Inhibitors 4424 4.1. Binding of Ureates and Hydroxamates 4425 4.2. Thiol Derivatives 4426 4.3. Metal-Complexing Anions 4428 4.4. Sulfonamides 4428 4.4.1. Benzenesulfonamides 4428 4.4.2. Thiophene, Thiadiazole, and Thiadiazoline Derivatives 4440 4.4.3. Sulfonamides Containing Other Ring Systems 4443 4.4.4. Thiazide Diuretics 4445 4.4.5. Aliphatic Sulfonamides 4446 4.5. Sulfamates and Sulfamides 4447 4.5.1. Aliphatic Sulfamates 4448 4.5.2. Sulfamate CAIs Also Acting as Steroid Sulfatase and Aromatase Inhibitors 4450 4.6. Sulfonamides/Sulfamates/Sulfamides Containing Sugar Moieties 4452 5. Insights into CA Inhibition: Structural Features of Non-Zinc-Binding Inhibitors 4455 5.1. Compounds Anchoring to the Zinc Bound Water Molecule 4455 5.1.1. Phenols 4455 5.1.2. Spermine and Related Polyamines 4456 5.2. Compounds Located at the Entrance of the Active Site: Coumarins and Lacosamide 4457 6. Conclusions 4459 Author Information 4461 Corresponding Author 4461 Notes 4461 Biographies 4461 Acknowledgments 4462 Abbreviations 4462 References 4462

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Section: Insights Into Ca Inhibition: Structural Features Of Zinc Bin...mentioning

confidence: 99%

Multiple Binding Modes of Inhibitors to Carbonic Anhydrases: How to Design Specific Drugs Targeting 15 Different Isoforms?

et al. 2012

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“…The role of the microcirculation is increasingly being recognized in the pathophysiology of cardiovascular diseases; eg. hypertension [1][2][3] and diabetes [4][5][6]. In particular, assessing retinal blood flow can be potentially useful for understanding diabetic retinopathies [7], and study the relationships between vascularization and glaucoma [8][9][10][11][12].…”

Section: Introduction a Motivationsmentioning

confidence: 99%

Holographic laser Doppler imaging of microvascular blood flow

et al. 2014

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We report on local superficial blood flow monitoring in biological tissue from laser Doppler holographic imaging. In time-averaging recording conditions, holography acts as a narrowband bandpass filter, which, combined with a frequency-shifted reference beam, permits frequency-selective imaging in the radiofrequency range. These Doppler images are acquired with an off-axis Mach-Zehnder interferometer. Microvascular hemodynamic components mapping is performed in the cerebral cortex of the mouse and the eye fundus of the rat with near-infrared laser light without any exogenous marker. These measures are made from a basic inverse-method analysis of local first-order optical fluctuation spectra at low radiofrequencies, from 0 Hz to 100 kHz. Local quadratic velocity is derived from Doppler broadenings induced by fluid flows, with elementary diffusing wave spectroscopy formalism in backscattering configuration. We demonstrate quadratic mean velocity assessment in the 0.1-10 mm/s range in vitro and imaging of superficial blood perfusion with a spatial resolution of about 10 micrometers in rodent models of cortical and retinal blood flow.

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“…This alteration may be ascribed to a rarefaction at the capillary level, which plays a significant role in the reduction of CBF induced by hypertension [21, 22]. It has been previously demonstrated that long-term cerebral arteriolar contraction causes the decrease in the number of open microvessels and diminishes the CBF in SHR [23, 24].…”

Section: Discussionmentioning

confidence: 99%

Long-Term Stimulation with Electroacupuncture at DU20 and ST36 Rescues Hippocampal Neuron through Attenuating Cerebral Blood Flow in Spontaneously Hypertensive Rats

Tian

Sun

Huang

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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This study was designed to investigate the effect of long-term electroacupuncture at Baihui (DU20) and Zusanli (ST36) on cerebral microvessels and neurons in CA1 region of hippocampus in spontaneously hypertensive rats (SHR). A total of 45 male Wistar rats and 45 SHR were randomly grouped, with or without electroacupuncture (EA) at DU20 and ST36, once every other day for a period of 8 weeks. The mean arterial pressure (MAP) was measured once every 2 weeks. Cerebral blood flow (CBF) and the number of open microvessels in hippocampal CA1 region were detected by Laser Doppler and immunohistochemistry, respectively. Nissl staining and Western blotting were performed, respectively, to determine hippocampus morphology and proteins that were implicated in the concerning signaling pathways. The results showed that the MAP in SHR increased linearly over the observation period and was significantly reduced following electroacupuncture as compared with sham control SHR rats, while no difference was observed in Wistar rats between EA and sham control. The CBF, learning and memory capacity, and capillary rarefaction of SHR were improved by EA. The upregulation of angiotensin II type I receptor (AT1R), endothelin receptor (ETAR), and endothelin-1 (ET-1) in SHR rats was attenuated by electroacupuncture, suggesting an implication of AT1R, ETAR, and ET-1 pathway in the effect of EA.

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The Microcirculation and Hypertension

Cited by 35 publications

References 65 publications

Multiple Binding Modes of Inhibitors to Carbonic Anhydrases: How to Design Specific Drugs Targeting 15 Different Isoforms?

Multiple Binding Modes of Inhibitors to Carbonic Anhydrases: How to Design Specific Drugs Targeting 15 Different Isoforms?

Holographic laser Doppler imaging of microvascular blood flow

Long-Term Stimulation with Electroacupuncture at DU20 and ST36 Rescues Hippocampal Neuron through Attenuating Cerebral Blood Flow in Spontaneously Hypertensive Rats

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