The microcephaly geneASPMis required for the timely generation of human outer-radial glia progenitors by controlling mitotic spindle orientation
Anja van Benthem,
Ridha Limame,
Matteo Piumatti
et al.
Abstract:Abnormal spindle-like, microcephaly-associated (ASPM) is the most commonly mutated gene in primary microcephaly (MCPH), characterized by reduced brain size and intellectual deficiency. The mechanisms underlying MCPH have remained unclear, as ASPM disruption leads to distinct phenotypes depending on the species studied. Here, we studied the impact of ASPM pathogenic mutations on human corticogenesis in organoid models. We found that at earliest stages of neurogenesis, ASPM mutant cortical progenitors, located a… Show more
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