Excepting some specific efforts, most of the mainstream debate around the Americas' settlement has been directed by specialists dealing with partial evidence. Thus, discussions have been confined to particular academic and scientific environments with limited interchange among archeologists, physical anthropologists, linguists, geneticists, geologists, paleontologists, and so on. As a consequence, integrative views about a process that is complex by definition have been scarce and driven by confrontation rather than by a search for common results. Still, an increasing number of specialists are attempting to integrate different types of data. In our view, a proper way to do this is to focus the discussion around evolutionary or cultural processes and the putative patterns that such processes could have generated in the different types of data, which in turn, depend on the nature of the data. In this way, the analyses and conclusions can be interpreted as "model-bound" rather than purely inferential. In this paper, we first provide a brief summary of main differences among the two main sources of biological informationgenetics and craniofacial size and shape-along with the main conclusions that the patterns of genetic and craniofacial variation provide. Furthermore, we exemplify the above-mentioned notion by discussing two particular processes and their hypothetical impact on genetic and craniofacial data: the influence of bottlenecks during the early dispersal and a putative zone of gene flow among Asian and American Circum-Arctic populations.Keywords Bottlenecks . Arctic gene flow . Skull shape . mtDNA . Y-chromosome . Autosomal markers . Native Americans Humans have always been curious about their origins back before the rise of civilization. However, only with the advent of science were widely accepted methods established in order to answer many issues regarding our own history. Archeology and paleontology have long offered theoretical tools and empirical evidence to support research on modern Homo sapiens origins and its extraordinary outof-Africa expansion and adaptive radiation to previously unoccupied continents (Collard et al. 2007;Foley and Lahr 2003;Lahr 1996;Rightmire et al. 2007;Stringer et al. 1995). This scenario, however, experienced a major revolution in the past century with the emergence of genetics and more recently, of molecular biology, because both disciplines have brought new tools to uncover the unregistered past of human populations (see recent examples in Blum and Jakobsson 2010;Rasmussen et al. 2010;Ray et al. 2009). Additionally, population and quantitative genetics provide a formal, proper framework to make inferences around the four central concepts of Darwinian thought (multiplication, heredity, variation, and competition by natural selection) and further concepts emphasized by modern evolutionary theory as well (stochastic factors, epigenesis, genomics, evolutionary development, geneculture coevolution, etc.). To sum up, a highly stimulating set of disciplines contributes ...