The microbiota–gut–brain axis: A promising avenue to foster healthy developmental outcomes

Brett, Bonnie E.; Weerth, Carolina de

doi:10.1002/dev.21824

Cited by 21 publications

(16 citation statements)

References 137 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In clinical studies, intestinal alterations, hyperendotoxemia, and neuroinflammation have been shown in obese individuals, AD patients, and individuals with brain amyloidosis (Cattaneo et al, 2017;Cryan and Dinan, 2012;Ley et al, 2006). Meanwhile, dietary supplementation with probiotics or prebiotics can prevent cognitive impairment via the microbiota-gut-brain axis (Wang et al, 2016;Jiang et al, 2017;Li et al, 2018;Brett and de Weerth, 2019;Sun et al, 2019). Therefore, this axis is a feasible target for the prevention and treatment of cognitive impairment induced by HF diet.…”

Section: Introductionmentioning

confidence: 99%

Curdlan Prevents the Cognitive Deficits Induced by a High-Fat Diet in Mice via the Gut-Brain Axis

et al. 2020

View full text Add to dashboard Cite

A high-fat (HF) diet is a major predisposing factor of neuroinflammation and cognitive deficits. Recently, changes in the gut microbiota have been associated with neuroinflammation and cognitive impairment, through the gut-brain axis. Curdlan, a bacterial polysaccharide widely used as food additive, has the potential to alter the composition of the microbiota and improve the gut-brain axis. However, the effects of curdlan against HF diet-induced neuroinflammation and cognitive decline have not been investigated. We aimed to evaluate the neuroprotective effect and mechanism of dietary curdlan supplementation against the obesity-associated cognitive decline observed in mice fed a HF diet. C57Bl/6J male mice were fed with either a control, HF, or HF with curdlan supplementation diets for 7 days (acute) or 15 weeks (chronic). We found that acute curdlan supplementation prevented the gut microbial composition shift induced by HF diet. Chronic curdlan supplementation prevented cognitive declines induced by HF diet. In addition, curdlan protected against the HF diet-induced abnormities in colonic permeability, hyperendotoxemia, and colonic inflammation. Furthermore, in the prefrontal cortex (PFC) and hippocampus, curdlan mitigated microgliosis, neuroinflammation, and synaptic impairments induced by a HF diet. Thus, curdlan-as a food additive and prebiotic-can prevent cognitive deficits induced by HF diet via the colon-brain axis.

show abstract

Section: Introductionmentioning

confidence: 99%

Curdlan Prevents the Cognitive Deficits Induced by a High-Fat Diet in Mice via the Gut-Brain Axis

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Furthermore, evidence from germ-free, antibiotic-treated and pathogen-free rodents has revealed gut microbiota dysbiosis negatively affect hippocampal neurogenesis and brain development via microglia activation [11,12], suggesting a vital role of gut microbiota in cognitive function. Therefore, the gut-brain axis is considered as the potential therapeutic target for HF induced neuroinflammation and cognitive decline [13][14][15][16].…”

mentioning

confidence: 99%

β-Glucan from Lentinula edodes prevents cognitive impairments in high-fat diet-induced obese mice: involvement of colon-brain axis

et al. 2021

View full text Add to dashboard Cite

Background Long-term high fat (HF) diet intake can cause neuroinflammation and cognitive decline through the gut-brain axis. (1, 3)/(1, 6)-β-glucan, an edible polysaccharide isolated from medical mushroom, Lentinula edodes (L. edodes), has the potential to remodel gut microbiota. However, the effects of L. edodes derived β-glucan against HF diet-induced neuroinflammation and cognitive decline remain unknown. This study aimed to evaluate the neuroprotective effect and mechanism of dietary L edodes β-glucan supplementation against the obesity-associated cognitive decline in mice fed by a HF diet. Methods C57BL/6J male mice were fed with either a lab chow (LC), HF or HF with L. edodes β-glucan supplementation diets for 7 days (short-term) or 15 weeks (long-term). Cognitive behavior was examined; blood, cecum content, colon and brain were collected to evaluate metabolic parameters, endotoxin, gut microbiota, colon, and brain pathology. Results We reported that short-term and long-term L. edodes β-glucan supplementation prevented the gut microbial composition shift induced by the HF diet. Long-term L. edodes β-glucan supplementation prevented the HF diet-induced recognition memory impairment assessed by behavioral tests (the temporal order memory, novel object recognition and Y-maze tests). In the prefrontal cortex and hippocampus, the β-glucan supplementation ameliorated the alteration of synaptic ultrastructure, neuroinflammation and brain-derived neurotrophic factor (BDNF) deficits induced by HF diet. Furthermore, the β-glucan supplementation increased the mucosal thickness, upregulated the expression of tight junction protein occludin, decreased the plasma LPS level, and inhibited the proinflammatory macrophage accumulation in the colon of mice fed by HF diet. Conclusions This study revealed that L. edodes β-glucan prevents cognitive impairments induced by the HF diet, which may occur via colon-brain axis improvement. The finding suggested that dietary L. edodes β-glucan supplementation may be an effective nutritional strategy to prevent obesity-associated cognitive decline.

show abstract

“…Studies have also linked alterations in the microbiome composition to cognitive functioning in humans (27). It was recently reported that the microbiome of children measured at one year of age correlated with cognitive functioning and brain volume at age one and two (28) an association which has been confirmed in other studies (29)(30)(31). However, only a few studies have discussed the relationship between the microbiome and cognitive functioning in older infants and young children, where mental health and cognitive outcomes are already more advanced and easier to evaluate.…”

Section: Introductionmentioning

confidence: 68%

Microbiome profiles are associated with cognitive functioning in 45-month-old children

Streit

Prandovszky²,

Send

et al. 2021

Preprint

View full text Add to dashboard Cite

Prenatal, perinatal, and postnatal factors have been shown to shape neurobiological functioning and alter the risk for mental disorders later in life. The gut microbiome is established early in life, and interacts with the brain via the brain-immune-gut axis. However, little is known about how the microbiome relates to early-life cognitive functioning in children. The present study, where the fecal microbiome of 380 children was characterized using 16s rDNA and metagenomic sequencing aimed to investigate the association between the microbiota and cognitive functioning of children at the age of 45 months measured with the Wechsler Preschool and Primary Scale of Intelligence (WPPSI-III). Overall the microbiome profile showed a significant association with cognitive functioning. A strong correlation was found between cognitive functioning and the relative abundance of an unidentified genus of the family Enterobacteriaceae. Follow-up mediation analyses revealed significant mediation effects of the level of this genus on the associations of maternal smoking during pregnancy and current maternal smoking with cognitive functioning. Metagenomic sequencing of a subset of these samples indicated that the identified genus was most closely related to Enterobacter asburiae. Our results indicate that alteration of the gut microflora is associated with cognitive functioning in childhood. Furthermore, they suggest that the altered microflora might interact with other environmental factors such as maternal cigarette smoking by acting as a mediator between those factors and child cognitive function. Interventions directed at altering the microbiome should be explored in terms of improving cognitive functioning in young children.

show abstract

The microbiota–gut–brain axis: A promising avenue to foster healthy developmental outcomes

Cited by 21 publications

References 137 publications

Curdlan Prevents the Cognitive Deficits Induced by a High-Fat Diet in Mice via the Gut-Brain Axis

Curdlan Prevents the Cognitive Deficits Induced by a High-Fat Diet in Mice via the Gut-Brain Axis

β-Glucan from Lentinula edodes prevents cognitive impairments in high-fat diet-induced obese mice: involvement of colon-brain axis

Microbiome profiles are associated with cognitive functioning in 45-month-old children

Contact Info

Product

Resources

About