The Microbiota and Transgenomic Networks: Potential Implications for Maternal-Fetal Medicine

Santolaya-Forgas, Joaquín; Townsend, R.; Santolaya, Joaquín; Patel, Priya; Herrera-Garcia, Guadalupe; Castracane, V. Daniel

doi:10.1159/000441452

Cited by 2 publications

(1 citation statement)

References 31 publications

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“…Complex genomic approaches, such as amplification and sequencing of the 16S rRNA gene and bacterial community genes and genomes, are emerging to help us to better understand the complexity of the microbial ecosystem during gestation [15]. Thus, 6 community state types (CSTs) have been identified, 4 of which are Lactobacillusdominated (CST I, Lactobacillus crispatus; CST II, Lactobacillus gasseri; CST III, Lactobacillus iners; CST V, Lactobacillus jensenii).…”

Section: The Vaginal Microbiome Influencementioning

confidence: 99%

Noninvasive Sampling of the Intrauterine Environment in Women with Preterm Labor and Intact Membranes

2017

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Spontaneous preterm birth has enormous consequences for newborns, children, and families. Intra-amniotic inflammation (IAI) is the leading cause of spontaneous preterm delivery, mainly at earlier gestational ages. Amniocentesis is the only method used to identify IAI in clinical practice. Although it is an invasive procedure with a very low risk of complications, many women and physicians are hesitant about amniocentesis on this indication. This has been an incentive to explore IAI and the intra-amniotic environment through noninvasive techniques, such as sampling cervical mucus, vaginal fluid, or maternal blood. With this overview, we aim to provide a concise update on the state of the art of the noninvasive sampling of the intrauterine environment in women with preterm labor and intact membranes. So far, it is unknown whether this screening helps improve our knowledge about the impact of IAI on the neonatal and long-term outcome, but we believe it merits this review.

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Section: The Vaginal Microbiome Influencementioning

confidence: 99%

Noninvasive Sampling of the Intrauterine Environment in Women with Preterm Labor and Intact Membranes

2017

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Association of histological chorioamnionitis and magnesium sulfate treatment in singleton and dichorionic twin pregnancies with preterm premature rupture of membranes: preliminary observations

O’Brien

Santolaya

Palomares

et al. 2017

Journal of Perinatal Medicine

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Objective To evaluate the possible association between antenatal magnesium sulfate treatment with histological chorioamnionitis in patients with singleton or dichorionic twins that had preterm premature rupture of the membranes. Methods This was an observational study performed in patients admitted to the hospital with rupture of membranes before 34 weeks' gestation. The primary outcome was histological chorioamnionitis and the primary predictor was antenatal magnesium sulfate treatment. A logistic regression model was used without consideration of other antenatal medical treatments. Results Among 107 patients with preterm deliveries, 57 were admitted to the hospital before 34 weeks' gestation with preterm premature rupture of membranes. Fifty-cases were excluded from the analysis because they were admitted after 34 weeks' gestation, delivered before 24 weeks' gestation or had intrauterine fetal demise or monochorionic twins. The logistic regression analysis adjusting for maternal age, gravidity, parity, multiple gestation, gestational age at delivery, and birthweight, indicated that patients with singleton pregnancies and histological chorioamnionitis had received magnesium sulfate antenatally more frequently (χ2=6.46; P=0.01). The association between histological chorioamnionitis and magnesium sulfate treatment was not found among patients with dichorionic twin pregnancies with one intact gestational sac. Conclusions In this cohort of patients with preterm premature rupture of membranes admitted to the hospital before 34 week's gestation, those with singleton pregnancies treated antenatally with magnesium sulfate for neonatal neuroprotection had a greater rate of histological chorioamnionitis.

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The Microbiota and Transgenomic Networks: Potential Implications for Maternal-Fetal Medicine

Cited by 2 publications

References 31 publications

Noninvasive Sampling of the Intrauterine Environment in Women with Preterm Labor and Intact Membranes

Noninvasive Sampling of the Intrauterine Environment in Women with Preterm Labor and Intact Membranes

Association of histological chorioamnionitis and magnesium sulfate treatment in singleton and dichorionic twin pregnancies with preterm premature rupture of membranes: preliminary observations

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