The microbiome of translocated bacterial populations in patients with and without inflammatory bowel disease

Kiely, Christopher J.; Pavli, Paul; O’Brien, Claire

doi:10.1111/imj.13998

Cited by 17 publications

(14 citation statements)

References 42 publications

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“…Parabacteroides in high abundance was found in immune-related diarrhea [39]. In addition, Alloprevotella ( Prevotellaceae family) is an anaerobic Gram-negative bacilli with the high relative abundance in patients with inflammatory bowel disease (IBD) [40]. Both Desulfovibrio and Acinetobacter ( Proteobacteria family) were associated with bloody diarrhea [41, 42].…”

Section: Discussionmentioning

confidence: 99%

Gut microbial modulation in the treatment of chemotherapy-induced diarrhea with Shenzhu Capsule

Wang

Feng

Zhang

et al. 2019

BMC Complement Altern Med

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Background: Gut microbiota plays a crucial role in the treatment of gastrointestinal (GI) diseases such as chemotherapy-induced diarrhea (CID). Shenzhu Capsule (SZC) is a Chinese herbal formula, which is composed of Renshen (rhizomes of Panax ginseng C. A. Mey.) and Baizhu (rhizomes of Atractylodes macrocephala Koidz.). Many Chinese traditional anti-diarrheal formulae that contain Renshen and Baizhu are capable of effectively alleviating CID. However, the efficacy in vivo and potential mechanism of SZC (the form of compatibility of Renshen and Baizhu) in the treatment of CID had not been elucidated. Here, this study aimed to investigate whether SZC exhibited the antidiarrheal activity, and whether gut microbiota was involved in the therapeutic effect of SZC on CID. Methods: High performance liquid chromatography (HPLC), gas chromatography-mass spectrometer (GC-MS) and infrared spectroscopy (IR) analyses were used to characterize the extracted components in SZC. The mice were orally administrated with SZC in a preventive mode on the first 2 days of this experiment, and then intraperitoneally injected with 5-FU (40 mg/kg/d) for 6 days. SZC treatment lasted until the 3rd day after the end of 5-FU chemotherapy. We investigated the effects of SZC on body weights, diarrhea, thymus/spleen indexes, colonic tissues, and gut microbiota. Colonic histology was examined by hematoxylin-eosin (HE) staining. 16S rDNA Amplicon Sequencing was used to analyze the gut microbial structure from fecal samples. Results: SZC significantly increased the body weights and thymus/spleen indexes, alleviated diarrhea, and reversed histopathological changes of colons. In addition, gut microbiota analysis revealed that the overall structure of gut microbiota in CID mice was disturbed, but reversed to the normal state after SZC treatment. At genus level, SZC significantly inhibited the growth of some potential pathogens associated with diarrhea, such as Clostridiumm, Bacteroides, Parabacteroides, Alloprevotella, Acinetobacter and Pseudomonas. Conclusions: In our study, these data illustrated that SZC inhibited the growth of many potential pathogens during the alleviation of CID. Gut microbial modulation was associated with the anti-diarrheal activity of SZC.

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Section: Discussionmentioning

confidence: 99%

Gut microbial modulation in the treatment of chemotherapy-induced diarrhea with Shenzhu Capsule

Wang

Feng

Zhang

et al. 2019

BMC Complement Altern Med

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“…Limitations of this study include the small number of horses enrolled, which comprised a heterogeneous population with wide variation in age (between 1 and 21 years old) and breeds. Nevertheless, it has been shown that the microbiota of nine-month-old horses is very similar to adults [8] and that breed might not be a great factor of variability in the equine microbiota [9]. In addition, the treatment with antimicrobial drugs received by horses with colitis prior to sample collection likely induced changes in the microbiota [10].…”

Section: Comparison Between Healthy and Colitis Casesmentioning

confidence: 99%

“…Marked perturbation of the intestinal microbiota, particularly with respect to microbial diversity, has been documented in conditions such as inflammatory bowel disease, Crohn's disease and colitis in humans and in horses with undifferentiated colitis [7][8][9]. These observations suggest that in some cases of gastro-intestinal disorders, including horses, dysbiosis could play a role in the development of disease.…”

Section: Introductionmentioning

confidence: 99%

“…The advent of next-generation sequencing (NGS) platforms has allowed for the characterization of microbial communities from complex environments, such as the equine hind intestinal tract [ 6 , 7 ]. Marked perturbation of the intestinal microbiota, particularly with respect to microbial diversity, has been documented in conditions such as inflammatory bowel disease, Crohn’s disease and colitis in humans and in horses with undifferentiated colitis [ 7 , 8 , 9 ]. These observations suggest that in some cases of gastro-intestinal disorders, including horses, dysbiosis could play a role in the development of disease.…”

Section: Introductionmentioning

confidence: 99%

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Luminal and Mucosal Microbiota of the Cecum and Large Colon of Healthy and Diarrheic Horses

Arroyo

Rossi

Santos

et al. 2020

Animals

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The aim of this study was to compare the mucosal and luminal content microbiota of the cecum and colon of healthy and diarrheic horses. Marked differences in the richness and in the community composition between the mucosal and luminal microbiota of the cecum and large colon of horses with colitis were observed. Microbial dysbiosis occurs in horses with colitis at different levels of the intestinal tract, and microbiota composition is different between the mucosa and luminal content of diarrheic horses. The changes in some key taxa associated with dysbiosis in the equine intestinal microbiota, such as Escherichia, Fusobacterium and Lactobacillus, deserve further inquiry in order to determine their utility for disease diagnosis and treatment.

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“…Some of these research have been based on bacterial-culture studies. But, more recently, molecular techniques have used bacterial RNA/DNA from blood and tissues as surrogate markers enabling a deeper analysis and the identification of unculturable bacteria 189 . As a case in point, a recent study confirmed a distinctly different microbial profile between CD and UC lymph nodes that could explain their different mechanisms of development and prognosis 190 .…”

Section: Disrupted Permeabilitymentioning

confidence: 99%

Neuro-immuno-regulation of inflammation in the colonic mucosa : Focus on mast cells and eosinophils in bowel disorders

Casado‐Bedmar

2020

Linköping University Medical Dissertations

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The microbiome of translocated bacterial populations in patients with and without inflammatory bowel disease

Cited by 17 publications

References 42 publications

Gut microbial modulation in the treatment of chemotherapy-induced diarrhea with Shenzhu Capsule

Gut microbial modulation in the treatment of chemotherapy-induced diarrhea with Shenzhu Capsule

Luminal and Mucosal Microbiota of the Cecum and Large Colon of Healthy and Diarrheic Horses

Neuro-immuno-regulation of inflammation in the colonic mucosa : Focus on mast cells and eosinophils in bowel disorders

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