The Microbiome of the Prostate Tumor Microenvironment

Cavarretta, Ilaria T.; Ferrarese, Roberto; Cazzaniga, Walter; Saita, Diego; Lucianò, Roberta; Ceresola, Elisa Rita; Locatelli, Irene; Visconti, Laura; Lavorgna, G; Briganti, Alberto; Nebuloni, Manuela; Doglioni, Claudio; Clementi, Massimo; Montorsi, Francesco; Canducci, Filippo; Salonia, Andrea

doi:10.1016/j.eururo.2017.03.029

Cited by 163 publications

(144 citation statements)

References 29 publications

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“…While we have demonstrated the presence of SMCSO in prostate tissue, it is not clear whether it would have any metabolic activity itself, or whether any activity would be of a consequence of its degradation to biologically active derivatives. It may be noteworthy that there is increasing evidence for a microbiological community associated both with the urinary tract and the prostate itself that may metabolise SMCSO to its active derivatives …”

Section: Discussionmentioning

confidence: 99%

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Accumulation of Dietary S‐Methyl Cysteine Sulfoxide in Human Prostate Tissue

Coode-Bate

Sivapalan

Melchini

et al. 2019

Molecular Nutrition Food Res

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Scope Observational studies have associated consumption of cruciferous vegetables with reduced risk of prostate cancer. This effect has been associated with the degradation products of glucosinolates—thioglycosides that accumulate within crucifers. The possible role of S‐methyl cysteine sulfoxide, a metabolite that also accumulates in cruciferous vegetables, and its derivatives, in cancer prevention is relatively unexplored compared to glucosinolate derivatives. The hypothesis that consuming a broccoli soup results in the accumulation of sulfate (a SMCSO derivative) and other broccoli‐derived metabolites in prostate tissue is tested. Methods and results Eighteen men scheduled for transperineal prostate biopsy were recruited into a 4‐week parallel single blinded diet supplementation study (NCT02821728). Nine men supplemented their diet with three 300 mL portions of a broccoli soup each week for four weeks prior to surgery. Analyses of prostate biopsy tissues reveal no detectable levels of glucosinolates and derivatives. In contrast, SMCSO is detected in prostate tissues of the participants, with significantly higher levels in tissue of men in the supplementation arm. SMCSO was also found in blood and urine samples from a previous intervention study with the identical broccoli soup. Conclusion The consequences of SMCSO accumulation in prostate tissues and its potential role in prevention of prostate cancer remains to be investigated.

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Section: Discussionmentioning

confidence: 99%

“…Finally, it has been reported that the human prostate does have a commensal bacterial community . It is therefore possible that SMCSO accumulates in prostate tissue, and then is catabolized by a resident microbial population to bioactive components that may inhibit the proliferation of cancerous cell lines.…”

Section: Discussionmentioning

confidence: 99%

Accumulation of Dietary S‐Methyl Cysteine Sulfoxide in Human Prostate Tissue

Coode-Bate

Sivapalan

Melchini

et al. 2019

Molecular Nutrition Food Res

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“…As previously suggested from studies with microbial isolates from spatially distinct anatomical lung locations (Chung et al, 2017; Jorth et al, 2015), such variation may be the underlying cause for variation of disease severity within the lung and clinical episodes of exacerbations. Furthermore, the methodology developed herein can be extended to any human organ (notably, organs with tumors, which are known to be associated with their own unique microbiomes (Cavarretta et al, 2017; Cummins and Tangney, 2013; Flemer et al, 2017) and to map and correlate various other types of omics data such as metagenomes and transcriptomes. The method also opens the possibility to detect and visualize the environmental chemicals that a human is exposed to.…”

Section: Discussionmentioning

confidence: 99%

Three-Dimensional Microbiome and Metabolome Cartography of a Diseased Human Lung

Garg

Wang

Hyde

et al. 2017

Cell Host & Microbe

102

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Summary Our understanding of the spatial variation in the chemical and microbial make-up of an entire human organ remains limited, in part due to the size and heterogeneity of human organs and the complexity of the associated metabolome and microbiome. To address this challenge we developed a workflow to enable the cartography of metabolomic and microbiome data onto a three dimensional (3D) organ reconstruction built off radiological images. This enabled the direct visualization of the microbial and chemical makeup of a human lung from a cystic fibrosis patient. We detected host-derived molecules, microbial metabolites, medications, and region specific metabolism of medications and placed it in the context of microbial distributions in the lung. Our tool further created browsable maps of a 3D microbiome/metabolome reconstruction map on a radiological image of a human lung and forms an interactive resource for the scientific community.

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“…Fruge et al studied overweight men who received radical prostatectomy, and found that the Gleason sum was positively associated with Deferribacteres, Proteobacteria, Clostridium and inversely associated with Blautia . Gut microbiota was also different within PCa specimens, Staphylococcus was more abundant in tumor and peri‐tumor areas than non‐tumor tissues . However, these studies were conducted retrospectively on PCa patients, no prospective study of the interactions between diet, gut microbiota, and PCa has ever been reported.…”

Section: Introductionmentioning

confidence: 99%

“…Gut microbiota was also different within PCa specimens, Staphylococcus was more abundant in tumor and peri-tumor areas than non-tumor tissues. 9 However, these studies were conducted retrospectively on PCa patients, no prospective study of the interactions between diet, gut microbiota, and PCa has ever been reported.…”

Section: Introductionmentioning

confidence: 99%

Combined maternal and post‐weaning high fat diet inhibits male offspring's prostate cancer tumorigenesis in transgenic adenocarcinoma of mouse prostate model

Liu

Jiang

2019

The Prostate

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Background High fat diet (HFD) and its responsive change of gut microbiota are associated with numerous diseases in human and animal studies. But how maternal and post‐weaning HFD may influence the tumorigenesis of prostate cancer (PCa) in male offspring has not yet been reported. Methods We studied both solitary and combined effects of maternal or/and post‐weaning HFD on the tumorigenesis of prostate in offspring using a transgenic adenocarcinoma of mouse prostate (TRAMP) model. TRAMP male mice (n = 24) were born to and fostered onto control diet or HFD‐fed mothers, the weaned pups were further fed control or fat diet. All mice were sacrificed at the 28th week. The prostate histopathology was performed. The gut microbiota was analyzed by fecal 16S rRNA pyrosequencing, and the serum metabolites were determined by LC‐MS/MS. Results Our results indicated that post‐weaning HFD could significantly promote the PCa tumorigenesis in offspring (P = 0.031), and similar results were found in maternal HFD group but with no significant differences (P = 0.056). However, combined maternal and post‐weaning HFD could significantly reduce the PCa tumorigenesis in offspring (P = 0.019). Significant differences in specific microbial populations and serum metabolites were observed across groups. For example, mice with combined maternal and post‐weaning HFD had higher abundance of gut Lachonospiraceae, Roseburia, and Amycolatopsis, increased serum L‐methionine (P = 0.0052), and decreased serum α‐linolenic acid (P < 0.001). Conclusions This study highlights the inhibitory effects of combined maternal and post‐weaning HFD on PCa tumorigenesis, and provides new insights into the interactions between diet, gut microbiota, serum metabolites, and PCa.

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The Microbiome of the Prostate Tumor Microenvironment

Cited by 163 publications

References 29 publications

Accumulation of Dietary S‐Methyl Cysteine Sulfoxide in Human Prostate Tissue

Accumulation of Dietary S‐Methyl Cysteine Sulfoxide in Human Prostate Tissue

Three-Dimensional Microbiome and Metabolome Cartography of a Diseased Human Lung

Combined maternal and post‐weaning high fat diet inhibits male offspring's prostate cancer tumorigenesis in transgenic adenocarcinoma of mouse prostate model

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