The microbiome of the maxillary sinus and middle nasal meatus in chronic rhinosinusitis

Іванченко, О. А.; Karpishchenko, S.A.; Kozlov, Roman; Кречикова, О И; Otvagin, I V; Sopko, O N; Пискунов, Г. З.; Лопатин, А С

doi:10.4193/rhin15.018

Cited by 23 publications

(26 citation statements)

References 9 publications

(10 reference statements)

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“…Sinus mucosa produces nitric oxide (NO), which is a vascular mediator . New concepts such as sinus microbiota and microbiome have revealed the complexity of the physiopathology of chronic sinusitis . We cannot explain why, in our study, fungal ball was found in the smallest MS in the FB group in 93% of cases.…”

Section: Discussionmentioning

confidence: 57%

Maxillary sinus volume: new physiopathological data in fungal ball genesis? A retrospective study

Michel

Radulesco

Mancini

et al. 2017

Clinical Otolaryngology

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Section: Discussionmentioning

confidence: 57%

Maxillary sinus volume: new physiopathological data in fungal ball genesis? A retrospective study

Michel

Radulesco

Mancini

et al. 2017

Clinical Otolaryngology

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“…The antibiotic abuse among other medications by most of our patients could have rendered the antrum sterile as at the time of the study. Pathogenic anaerobic organisms have been isolated with varied frequencies from similar studies that included anaerobic isolation from maxillary antral specimens of patients with chronic maxillary sinusitis (19,(33)(34)(35).…”

Section: Discussionmentioning

confidence: 99%

Aerobic bacteria and fungal isolates in maxillary sinusitis of adults in a resource poor environment

Fasunla¹,

Fayemiwo²,

Bakare³

et al. 2018

Af J Clin Exp Micro

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Background: Infective rhinosinusitis is a common clinical condition which if left unattended to could result in various degrees of both morbidity and mortality. We aimed to identify aerobic and fungal organisms implicated in acute and chronic maxillary sinusitis and determine their antibiotic sensitivity patterns among adults in South Western Nigeria. Materials and methods: This was a cross sectional study of adults with clinical and radiological diagnosis of maxillary sinusitis treated at the University College Hospital, Ibadan over a period of one-year. Semi-structured questionnaire was administered to each consented adult to obtain relevant demographic and clinical data. Maxillary antral proof puncture was done to obtain specimen for microscopy, culture and sensitivity for aerobic bacterial and fungal isolates. Descriptive statistics was used in the data analysis. Results: Seventy-nine patients (49.4% males and 50.6% females) with acute maxillary sinusitis (17.7%), and chronic maxillary sinusitis (82.3%) were recruited into the study. The mean age of the patients was 32.9 years (SD=12.78; Range: 19-59). All patients presented with rhinorrhea while 92.8% had nasal obstruction. Fifty eight (73.4%) patients had history of antibiotic usage before presentation. Eight (57.1%) of the specimens from acute maxillary sinusitis cases and 40 (61.5%) of the specimens from chronic maxillary sinusitis yielded significant growth of bacteria and fungi respectively while 2 (3.5%) yielded mixed bacterial growth. Organisms commonly isolated from these specimens were Streptococcus pneumonia, Staphylococcus aureus, Pseudomonas aeruginosa, Haemophilus influenzae, and Aspergillus spp. The bacteria isolates were sensitive to Amoxicillin, Ciprofloxacin, Perfloxacin, Sparfloxacin and Ceftriaxone. Conclusion: The leading aerobic bacterial isolates from acute and chronic maxillary sinusitis were Streptococcus pneumonia and Staphylococcus aureus respectively. Fungal infections are seen only in chronic cases. It is recommended that where there are no microbiologic laboratory facilities, any of Ciprofloxacin, Perfloxacin, Sparfloxacin, and Amoxicillin can be administered empirically to treat infective maxillary sinusitis.

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“…Therefore, logic dictates that if antibiotic therapy targets only the classic culprits of sinusitis, with Gram-negatives present, we may be achieving an incomplete or even inappropriate eradication of microflora and pathogens. This could explain and contribute to therapeutic failure in recurrent sinusitis, its transition into chronicity, and its interpretation as noninfectious [11][12][13][14][15][16][17][18][19].…”

Section: Finding E Coli In Patients Chronically Ill With Sinusitismentioning

confidence: 99%

Chronic Sinusitis: The Empiric Treatment Strikes Back: Is CRS Directly Caused by Infectious Agent(s)?

Nowicki¹,

Nowicki²,

Nowicki³

et al. 2019

Rhinosinusitis

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Chronic sinusitis leads to unresolved infection and inflammation resulting in tissue remodeling, then further propagates the vicious cycle of deterioration and dysfunction of the sinuses' natural defense mechanisms, and yet another cycle of infection and mucosal injury. Antibiotic therapy targeting pathogens classically implicated in sinusitis could augment the risk of therapeutic failure through the natural selection of resistant and/or virulent pathogens, especially in the presence of Gram-negative E. coli. Our recent demonstration of highly pathogenic E. coli, detected through intraoperative biopsy of sinus tissue, allowed the resolution of chronic sinusitis symptoms upon E. coli targeted therapy. The isolated E. coli carried three genes, each coding biofilm formation, which may, in part, account for the chronicity of E. coli sinusitis. We recommend that, patients with chronic sinusitis be considered for intraoperative biopsy for unusual pathogens, therefore allowing targeted therapy. In the future, use of vaccines and biofilm inhibitors might be an effective therapeutic consideration.

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The microbiome of the maxillary sinus and middle nasal meatus in chronic rhinosinusitis

Cited by 23 publications

References 9 publications

Maxillary sinus volume: new physiopathological data in fungal ball genesis? A retrospective study

Maxillary sinus volume: new physiopathological data in fungal ball genesis? A retrospective study

Aerobic bacteria and fungal isolates in maxillary sinusitis of adults in a resource poor environment

Chronic Sinusitis: The Empiric Treatment Strikes Back: Is CRS Directly Caused by Infectious Agent(s)?

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