The microbiome in prostate inflammation and prostate cancer

Porter, Corey M.; Shrestha, Eva; Peiffer, Lauren B.; Sfanos, Karen S.

doi:10.1038/s41391-018-0041-1

Cited by 142 publications

(117 citation statements)

References 92 publications

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“…Besides that, microbiome compositions were related with prostate health and disease. In fact, urinary, gastrointestinal, and oral microbiota signatures were associated with prostate alterations, including cancer [32]. Also, fecal microbiome analysis exhibited differences between prostate cancer and healthy samples [33].…”

Section: Microbiome and Cancermentioning

confidence: 98%

The Role of the Cervicovaginal Microbiome on the Genesis and as a Biomarker of Premalignant Cervical Intraepithelial Neoplasia and Invasive Cervical Cancer

Curty

Carvalho

Soares

2019

IJMS

120

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The microbiome is able to modulate immune responses, alter the physiology of the human organism, and increase the risk of viral infections and development of diseases such as cancer. In this review, we address changes in the cervical microbiota as potential biomarkers to identify the risk of cervical intraepithelial neoplasia (CIN) development and invasive cervical cancer in the context of human papillomavirus (HPV) infection. Current approaches for clinical diagnostics and the manipulation of microbiota with the use of probiotics and through microbiota transplantation are also discussed.

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Section: Microbiome and Cancermentioning

confidence: 98%

The Role of the Cervicovaginal Microbiome on the Genesis and as a Biomarker of Premalignant Cervical Intraepithelial Neoplasia and Invasive Cervical Cancer

Curty

Carvalho

Soares

2019

IJMS

120

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“…Estemalik et al showed oral pathogens in patients with chronic prostatitis and benign prostatic hyperplasia [32]. These findings indicate a possible association between the oral microbiome and prostate diseases, but comments on driver or bystander effects could not be made without further data [33].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of cancer risk in patients with periodontal diseases.

Güven

Dizdar

Akman

et al. 2018

JCO

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In this study, we aimed to assess the cancer risk among patients with periodontal disease. Materials and methods: Patients diagnosed with periodontal diseases at Hacettepe University between 2007 and 2012 were included and data on the diagnosis of any cancer after periodontal disease were collected from patient files. The age-and sex-standardized incidence rates (SIRs) were calculated using Turkish National Cancer Registry 2013 data. Results: A total of 5199 patients were included. Median follow-up was 7.2 years. Patients with periodontal diseases had 17% increased risk of cancer compared with the expected counts for the corresponding age and sex groups (SIR: 1.17; 95% CI: 1.04-1.3, P = 0.006). The increased cancer risk was statistically significant in women (SIR: 1.24; 95% CI: 1.05-1.45, P = 0.008) but not in men. Among women with periodontal disease, the risks of breast cancer (SIR: 2.19) and head and neck cancer (SIR: 4.71) were significantly increased. Among men, the risks of prostate cancer (SIR: 1.84), head and neck cancer (SIR: 3.55), and hematological cancers (SIR: 1.76) were significantly increased. Conclusion: This study showed that periodontal diseases were associated with increased risk of several cancers. Besides other wellknown benefits for health, the provision of oral/dental health should be considered and employed as a cancer prevention measure.

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“…It is well documented in human and veterinary studies that a commensal population is critical to maintain normal health (ie, gastrointestinal tract and skin) . Disruption in the intestinal microbiome has been associated with obesity, cystic fibrosis, various neoplasias, antibiotic resistance, and recurrent Clostridium difficile ‐associated diarrhea in humans . These diseases and more continue to be examined in‐depth in physician medicine following the massive undertaking of the Human Microbiome Project (HMP).…”

Section: Current Ocular Microbiome Researchmentioning

confidence: 99%

“…[48][49][50][51] Disruption in the intestinal microbiome has been associated with obesity, cystic fibrosis, various neoplasias, antibiotic resistance, and recurrent Clostridium difficile-associated diarrhea in humans. [28][29][30]48,[52][53][54][55][56][57][58] These diseases and more continue to be examined in-depth in physician medicine following the massive undertaking of the Human Microbiome Project (HMP). The goal of the HMP is to identify and improve the understanding of the healthy microbial communities present in and on the human body in healthy and disease states.…”

Section: Microbiome Researchmentioning

confidence: 99%

Veterinary ocular microbiome: Lessons learned beyond the culture

Banks

Ericsson

Reinero

et al. 2019

Veterinary Ophthalmology

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Ocular pathogens cause many painful and vision‐threatening diseases such as infectious keratitis, uveitis, and endophthalmitis. While virulent pathogens and pathobionts play important roles in disease pathogenesis, the scientific community has long assumed disruption of the ocular surface occurs prior to microbial colonization and subsequent infection. While nonpathogenic bacteria are often detected in corneal and conjunctival cultures from healthy eyes, cultures also frequently fail to yield growth of common ocular pathogens or nonpathogenic bacteria. This prompts the following question: Is the ocular surface populated by a stable microbial population that cannot be detected using standard culture techniques? The study of the microbiome has recently become a widespread focus in physician and veterinary medicine. Research suggests a pivotal symbiotic relationship with these microbes to maintain healthy host tissues, and when altered is associated with various disease states (“dysbiosis”). The microbiota that lives within and on mammalian bodies have long been known to influence health and susceptibility to infection. However, limitations of traditional culture methods have resulted in an incomplete understanding of what many now call the “forgotten organ,” that is, the microbiome. With the introduction of high‐throughput sequencing, physician ophthalmology has recognized an ocular surface with much more diverse microbial communities than suspected based on traditional culture. This article reviews the salient features of the ocular surface microbiome and highlights important future applications following the advent of molecular techniques for microbial identification, including characterizing ocular surface microbiomes in our veterinary species and their potential role in management of infectious and inflammatory ocular diseases.

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The microbiome in prostate inflammation and prostate cancer

Cited by 142 publications

References 92 publications

The Role of the Cervicovaginal Microbiome on the Genesis and as a Biomarker of Premalignant Cervical Intraepithelial Neoplasia and Invasive Cervical Cancer

The Role of the Cervicovaginal Microbiome on the Genesis and as a Biomarker of Premalignant Cervical Intraepithelial Neoplasia and Invasive Cervical Cancer

Evaluation of cancer risk in patients with periodontal diseases.

Veterinary ocular microbiome: Lessons learned beyond the culture

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