The microbiome in post-acute infection syndrome (PAIS)

Guo, Cheng; Yi, B. Alexander; Wu, Jian-Yong; Lu, Jiahai

doi:10.1016/j.csbj.2023.08.002

Cited by 5 publications

(6 citation statements)

References 97 publications

(131 reference statements)

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“…Although these observations may suggest the role of gut dysbiosis in the symptom development [53] a specific microbial signature has not been found yet [2]. Investigations of the microbiome dysbiosis was intensively studied in ME/CFS, with results indicating for a potential link between changes gut composition, including deficient butyrate-producing capacity and bacterial network disturbances, increased immune activation [54][55][56], and symptoms of fatigue symptoms [2,57]. That decreased availability of butyrate, along with other key mediators of the gut-brain axis produced during microbial fermentation, including serotonin and γ-aminobutyric acid (GABA) via influencing on intestinal permeability may have considerable impact on the neuro-immunoendocrine system [58].…”

Section: Role Of the Alerted Gut Microbiome In Me/cfs And Long Covid ...mentioning

confidence: 99%

A Narrative Review on Gut Microbiome Disturbances and Microbial Preparations in ME/CFS: Implications for Long COVID

Jurek,

Castro-Marrero

2024

Preprint

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Myalgic Encephalomyelitis, also known as Chronic Fatigue Syndrome (ME/CFS) and Long COVID are characterized by debilitating post-exertional malaise and other core symptoms related to immune dysregulation resultant from post-viral infection, including mitochondrial dysfunction, chronic neuroinflammation and gut dysbiosis. The reported associations between altered microbiota composition and cardinal symptoms of ME/CFS and Long COVID, suggesting that use of microbial preparations, such as probiotics, by restoring the homeostasis of the brain-immune-gut axis may help in the management of symptoms in both conditions. Therefore, this review aims to investigate the implications of alerted gut microbiome and assess the evidence supporting use of microbial-based preparations, including probiotics, synbiotics, postbiotics alone and/or in combination with other nutraceuticals in the management of fatigue, inflammation, as well as neuropsychiatric and gastrointestinal symptoms among patients with ME/CFS and Long COVID.

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Section: Role Of the Alerted Gut Microbiome In Me/cfs And Long Covid ...mentioning

confidence: 99%

A Narrative Review on Gut Microbiome Disturbances and Microbial Preparations in ME/CFS: Implications for Long COVID

Jurek,

Castro-Marrero

2024

Preprint

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“…Although these observations may suggest the role of gut dysbiosis in symptom development [ 53 ], a specific microbial signature has not yet been found [ 2 ]. Investigations of the microbiome dysbiosis have been intensively studied in ME/CFS, with results indicating a potential link between changes in gut composition, including deficient butyrate-producing capacity and bacterial network disturbances, increased immune activation [ 54 , 55 , 56 ] and symptoms of fatigue symptoms [ 2 , 57 ]. The decreased availability of butyrate, along with other key mediators of the gut–brain axis produced during microbial fermentation, including serotonin and γ-aminobutyric acid (GABA) via the influence of intestinal permeability, may have considerable impact on the neuro-immunoendocrine system [ 58 ].…”

Section: Role Of the Alerted Gut Microbiome In Me/cfs And Long Covid ...mentioning

confidence: 99%

A Narrative Review on Gut Microbiome Disturbances and Microbial Preparations in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Implications for Long COVID

Jurek,

Castro-Marrero

2024

Nutrients

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Myalgic encephalomyelitis, also known as chronic fatigue syndrome (ME/CFS), and long COVID are complex, multisystemic and long-term disabling conditions characterized by debilitating post-exertional malaise and other core symptoms related to immune dysregulation resultant from post-viral infection, including mitochondrial dysfunction, chronic neuroinflammation and gut dysbiosis. The reported associations between altered microbiota composition and cardinal symptoms of ME/CFS and long COVID suggest that the use of microbial preparations, such as probiotics, by restoring the homeostasis of the brain–immune–gut axis, may help in the management of symptoms in both conditions. Therefore, this review aims to investigate the implications of alerted gut microbiome and assess the evidence supporting use of microbial-based preparations, including probiotics, synbiotics, postbiotics alone and/or in combination with other nutraceuticals in the management of fatigue, inflammation and neuropsychiatric and gastrointestinal symptoms among patients with ME/CFS and long COVID.

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“…Notably, PAIS following mild to moderate COVID-19 shares many characteristics with chronic diseases triggered by other pathogens, which remain poorly understood. Various causes of PAIS have been proposed, including intestinal dysbiosis, autoimmunity, microvascular endothelial damage, and long-term persistence of pathogens and their pathogenic factors [ 146 , 147 , 148 ]. Slow Viral Diseases: These diseases manifest after a prolonged latent period with a slow, progressive course that often lasts several months to years and generally progresses until the end of life.…”

Section: Low-grade Inflammation In Long Covid and Other Viral Infectionsmentioning

confidence: 99%

Section: Low-grade Inflammation In Long Covid and Other Viral Infectionsmentioning

confidence: 99%

Exploring the Pathophysiology of Long COVID: The Central Role of Low-Grade Inflammation and Multisystem Involvement

Gusev,

Sarapultsev

2024

IJMS

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Long COVID (LC), also referred to as Post COVID-19 Condition, Post-Acute Sequelae of SARS-CoV-2 Infection (PASC), and other terms, represents a complex multisystem disease persisting after the acute phase of COVID-19. Characterized by a myriad of symptoms across different organ systems, LC presents significant diagnostic and management challenges. Central to the disorder is the role of low-grade inflammation, a non-classical inflammatory response that contributes to the chronicity and diversity of symptoms observed. This review explores the pathophysiological underpinnings of LC, emphasizing the importance of low-grade inflammation as a core component. By delineating the pathogenetic relationships and clinical manifestations of LC, this article highlights the necessity for an integrated approach that employs both personalized medicine and standardized protocols aimed at mitigating long-term consequences. The insights gained not only enhance our understanding of LC but also inform the development of therapeutic strategies that could be applicable to other chronic conditions with similar pathophysiological features.

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The microbiome in post-acute infection syndrome (PAIS)

Cited by 5 publications

References 97 publications

A Narrative Review on Gut Microbiome Disturbances and Microbial Preparations in ME/CFS: Implications for Long COVID

A Narrative Review on Gut Microbiome Disturbances and Microbial Preparations in ME/CFS: Implications for Long COVID

A Narrative Review on Gut Microbiome Disturbances and Microbial Preparations in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Implications for Long COVID

Exploring the Pathophysiology of Long COVID: The Central Role of Low-Grade Inflammation and Multisystem Involvement

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