The microbiome in dermatology

Musthaq, Shenara; A, Mazuy; Jakus, Jeannette

doi:10.1016/j.clindermatol.2018.03.012

Cited by 50 publications

(42 citation statements)

References 91 publications

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“…Using various state-of-the-art molecular and genetic-based methods, it was found that the skin microbiota is dominated by bacteria from the phyla Actinobacteria, Firmicutes, Proteobacteria, and Bacteroidetes; resident genera mainly include Propionibacterium spp., Staphylococcus spp., Micrococcus spp., Corynebacterium spp., and Acinetobacter spp. and the main representatives of the fungi being species of the genus Malassezia [15][16][17][18]. e diversity of skin microbiota among individuals depends on age, diet, gender, and environmental and geographical factors.…”

Section: Skin Microbiotamentioning

confidence: 99%

Efficacy of Using Probiotics with Antagonistic Activity against Pathogens of Wound Infections: An Integrative Review of Literature

Fijan

Frauwallner²,

Langerholc

et al. 2019

BioMed Research International

103

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e skin and its microbiota serve as physical barriers to prevent invasion of pathogens. Skin damage can be a consequence of illness, surgery, and burns. e most effective wound management strategy is to prevent infections, promote healing, and prevent excess scarring. It is well established that probiotics can aid in skin healing by stimulating the production of immune cells, and they also exhibit antagonistic effects against pathogens via competitive exclusion of pathogens. Our aim was to conduct a review of recent literature on the efficacy of using probiotics against pathogens that cause wound infections. In this integrative review, we searched through the literature published in the international following databases: PubMed, ScienceDirect, Web of Science, and Scopus using the search terms "probiotic" AND "wound infection." During a comprehensive review and critique of the selected research, fourteen in vitro studies, 8 animal studies, and 19 clinical studies were found. Two of these in vitro studies also included animal studies, yielding a total of 39 articles for inclusion in the review. e most commonly used probiotics for all studies were well-known strains of the species Lactobacillus plantarum, Lactobacillus casei, Lactobacillus acidophilus, and Lactobacillus rhamnosus. All in vitro studies showed successful inhibition of chosen skin or wound pathogens by the selected probiotics. Within the animal studies on mice, rats, and rabbits, probiotics showed strong opportunities for counteracting wound infections. Most clinical studies showed slight or statistically significant lower incidence of surgical site infections, foot ulcer infection, or burn infections for patients using probiotics. Several of these studies also indicated a statistically significant wound healing effect for the probiotic groups. is review indicates that exogenous and oral application of probiotics has shown reduction in wound infections, especially when used as an adjuvant to antibiotic therapy, and therefore the potential use of probiotics in this field remains worthy of further studies, perhaps focused more on typical skin inhabitants as next-generation probiotics with high potential.

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Section: Skin Microbiotamentioning

confidence: 99%

Efficacy of Using Probiotics with Antagonistic Activity against Pathogens of Wound Infections: An Integrative Review of Literature

Fijan

Frauwallner²,

Langerholc

et al. 2019

BioMed Research International

103

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“…Gut microbiota alterations (dysbiosis) have been associated with certain gastrointestinal diseases but also dysbiosis in the gut microbiota can be linked to nonintestinal diseases due to a possible influence on the immune modulation response of the host . The human gastrointestinal microbiota, or gut microbiota, and the skin microbiota are among the most studied to date. It is well established that the gut microbiota plays a key role in human health and diseases with a key influence on the development and maintenance of the immune homeostasis of the host .…”

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confidence: 99%

Gut microbiota dysbiosis in a cohort of patients with psoriasis

et al. 2019

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Summary Background There is increasing evidence of the key role that the gut microbiota plays in inflammatory diseases. Objectives To identify differences in the faecal microbial composition of patients with psoriasis compared with healthy individuals in order to unravel the microbiota profiling in this autoimmune disease. Methods 16S rRNA gene sequencing and bioinformatic analyses were performed with the total DNA extracted from the faecal microbiota of 19 patients with psoriasis and 20 healthy individuals from the same geographic location. Results Gut microbiota composition of patients with psoriasis displayed a lower diversity and different relative abundance of certain bacterial taxa compared with healthy individuals. Conclusions The gut microbiota profile of patients with psoriasis displayed a clear dysbiosis that can be targeted for microbiome‐based therapeutic approaches. What's already known about this topic? Psoriasis is a chronic inflammatory immune‐mediated skin disease, the aetiology of which remains unclear. The human microbiota is a complex microbial community that inhabits our body and has been related with the maintenance of a healthy status. Several studies have focused on the skin microbiome and its connection with psoriasis although less attention has been focused on the potential role of the gut microbiota in psoriatic disease. What does this study add? This study unravels the gut microbiome dysbiosis present in a cohort of patients with psoriasis, compared with a healthy control group from the same geographical location. This study shows a lower bacterial diversity and different relative abundance of certain bacterial taxa in patients with psoriasis. We gain knowledge and insight into the microbiome alterations in psoriatic disease, opening new avenues for therapeutic approaches to reshape the human microbiome towards a healthy status.

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“…Changes in skin microbiome composition were also observed in other dermatological conditions such as rosacea, acne, psoriasis, or seborrheic dermatitis; Demodex folliculorum, Bacillus oleronius, Helicobacter pylori, Staphylococcus epidermidis and Chlamydophila pneumonia were associated with rosacea (14,(22)(23)(24). In adolescence and adults with acne in the affected areas there were mostly lipophilic Propionibacterium (15).…”

Section: Modulating the Human Microbiome By Pre-and Probioticsmentioning

confidence: 98%

“…Another study has found an association between AD severity and the abundance of the genus Corynebacterium and the phylum Proteobacteria. The presence and chronicity of eczema appear to be more important determinants of skin microbiome configuration (14,15).…”

Section: Modulating the Human Microbiome By Pre-and Probioticsmentioning

confidence: 99%

Prebiotics and probiotics in atopic dermatitis (Review)

et al. 2019

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Recent years have brought additional data on the benefits of prebiotics and probiotics treatment in patients with atopic dermatitis. This review includes all the articles published in PubMed, Scopus, Embase and Cochrane databases until 05.06.2018. The terms used for the search were 'prebiotic', 'probiotic', 'atopic dermatitis', 'Severity Scoring of Atopic Dermatitis', and 'SCORAD'. There was an increase of the intestinal permeability reported in patients with atopic dermatitis and a reduction of the cutaneous microbiome diversity. Probiotics modulate the general microbiome and immune status by improving the intestinal barrier; these effects can be responsible for reducing allergic phenomenon and atopic dermatitis severity. We have structured the results by age groups as infants, 1-18 years, adults, and also pregnancy and lactation. Literature does not offer yet answers on the issues such as the optimal dosing, duration needed to see beneficial effects, the optimal time to start the treatment; the personalized use of probiotics according to colonic dysbiosis may be associated with better results. However, most randomized controlled trials and meta-analyzes support the administration of probiotics for at least 8 weeks in order to obtain beneficial effects in improving severity scoring of atopic dermatitis. Contents 1. Introduction 2. Definition of terms 3. Modulating the human microbiome by pre-and probiotics 4. Prebiotic and probiotic in atopic dermatitis 5. The type of probiotics used in clinical trials 6. Prebiotics-mechanism of action 7. Probiotics-mechanism of action 8. Conclusion

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The microbiome in dermatology

Cited by 50 publications

References 91 publications

Efficacy of Using Probiotics with Antagonistic Activity against Pathogens of Wound Infections: An Integrative Review of Literature

Efficacy of Using Probiotics with Antagonistic Activity against Pathogens of Wound Infections: An Integrative Review of Literature

Gut microbiota dysbiosis in a cohort of patients with psoriasis

Prebiotics and probiotics in atopic dermatitis (Review)

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