The microbiome in anti-cancer therapy

Bashiardes, Stavros; Tuganbaev, Timur; Federici, Sara; Elinav, Eran

doi:10.1016/j.smim.2017.04.001

Cited by 60 publications

(44 citation statements)

References 93 publications

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“…The tumor microbiome was found recently to play an important role in the effectiveness of cancer treatment (Bashiardes et al, 2017). Bladder cancer is routinely treated with the live bacterial tuberculosis vaccine Bacillus Calmette-Guerin (BCG) (Babjuk et al, 2011), and additional bacterial species are being explored for future cancer treatment (Quispe-Tintaya et al, 2013; Zheng et al, 2017).…”

Section: Discussion and Future Perspectivesmentioning

confidence: 99%

Tumor Targeting by Fusobacterium nucleatum: A Pilot Study and Future Perspectives

Abed

Maalouf

Parhi

et al. 2017

Front. Cell. Infect. Microbiol.

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Colorectal adenocarcinoma (CRC) is a common tumor with high mortality rates. Interestingly, CRC was found to be colonized by the oral anaerobic bacteria Fusobacterium nucleatum, which accelerates tumor progression and enables immune evasion. The CRC-specific colonization by fusobacteria is mediated through the recognition of tumor displayed Gal-GalNAc moieties by the fusobacterial Fap2 Gal-GalNAc lectin. Here, we show high Gal-GalNAc levels in additional adenocarcinomas including those found in the stomach, prostate, ovary, colon, uterus, pancreas, breast, lung, and esophagus. This observation coincides with recent reports that found fusobacterial DNA in some of these tumors. Given the tumorigenic role of fusobacteria and its immune evasion properties, we suggest that fusobacterial elimination might improve treatment outcome of the above tumors. Furthermore, as fusobacteria appears to specifically home-in to Gal-GalNAc—displaying tumors, it might be engineered as a platform for treating CRC and the above common, lethal, adenocarcinomas.

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Section: Discussion and Future Perspectivesmentioning

confidence: 99%

Tumor Targeting by Fusobacterium nucleatum: A Pilot Study and Future Perspectives

Abed

Maalouf

Parhi

et al. 2017

Front. Cell. Infect. Microbiol.

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“…IBD often exhibits extra-intestinal manifestations , and several other diseases are associated with intestinal dysbiosis. It is therefore possible that lack ofreduced Trm-priming is a general mechanism underlying the hygiene hypothesis in immune-mediated disease, and associations of microbiota with tumour development and cancer therapy 48,49 . Memory CD8 T-cells migrate to multiple tissues and escape homeostatic control mechanisms that limit their numbers in the circulation 50 , so numbers of Trm can accumulate throughout life in response to immunological experiences.…”

Section: Target Cd8 T-cell Proliferation Assayed After 4 Days Revealementioning

confidence: 99%

Deficient Resident Memory T Cell and CD8 T Cell Response to Commensals in Inflammatory Bowel Disease

Noble

Durant

Hoyles

et al. 2019

Journal of Crohn's and Colitis

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Background and Aims The intestinal microbiota is closely associated with resident memory lymphocytes in mucosal tissue. We sought to understand how acquired cellular and humoral immunity to the microbiota differ in health versus inflammatory bowel disease [IBD]. Methods Resident memory T cells [Trm] in colonic biopsies and local antibody responses to intraepithelial microbes were analysed. Systemic antigen-specific immune T and B cell memory to a panel of commensal microbes was assessed. Results Systemically, healthy blood showed CD4 and occasional CD8 memory T cell responses to selected intestinal bacteria, but few memory B cell responses. In IBD, CD8 memory T cell responses decreased although B cell responses and circulating plasmablasts increased. Possibly secondary to loss of systemic CD8 T cell responses in IBD, dramatically reduced numbers of mucosal CD8+ Trm and γδ T cells were observed. IgA responses to intraepithelial bacteria were increased. Colonic Trm expressed CD39 and CD73 ectonucleotidases, characteristic of regulatory T cells. Cytokines/factors required for Trm differentiation were identified, and in vitro-generated Trm expressed regulatory T cell function via CD39. Cognate interaction between T cells and dendritic cells induced T-bet expression in dendritic cells, a key mechanism in regulating cell-mediated mucosal responses. Conclusions A previously unrecognised imbalance exists between cellular and humoral immunity to the microbiota in IBD, with loss of mucosal T cell-mediated barrier immunity and uncontrolled antibody responses. Regulatory function of Trm may explain their association with intestinal health. Promoting Trm and their interaction with dendritic cells, rather than immunosuppression, may reinforce tissue immunity, improve barrier function, and prevent B cell dysfunction in microbiota-associated disease and IBD aetiology.

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“…These factors likely contributed to the paucity of data on interactions between the microbiome and psychological outcomes. Differences in baseline microbiome composition and microbiome response to treatment (e.g., colonization by introduced probiotic species) are factors that may contribute to individual differences in physical and mental health outcomes, as observed in two studies within the present dataset (Nation et al, ; Roos et al, ), as well as in other cases (e.g., microbiome modulation of cancer therapy efficacy; (Bashiardes, Tuganbaev, Federici, & Elinav, ; Gopalakrishnan, Helmink, Spencer, Reuben, & Wargo, ).…”

Section: Discussionmentioning

confidence: 62%

What can the gut microbiome teach us about the connections between child physical and mental health? A systematic review

Kan

Cowan

Ooi

et al. 2019

Developmental Psychobiology

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A deeper understanding of the gut–brain axis is of significance in pediatrics, given the influential role of early childhood experiences and exposures in shaping the microbiome, and health, across the life course. This systematic review synthesized evidence on the connection between the gut microbiome and mental health in children with physical illness. Six electronic databases were systematically searched and data extracted according to the Preferred Reporting Items for Systematic reviews and Meta‐Analyses (PRISMA) guidelines. Of 1,476 identified articles, 11 articles reporting on nine unique studies (all randomized controlled trials) were included. Most studies examined the gut microbiome in infants with colic, while the remaining studies investigated outcomes in children aged 1 day to 18 years at risk for atopic dermatitis or irritable bowel syndrome. Baseline and postintervention gut microbiome differences varied across studies. Findings on psychological functioning also varied, with only half of the captured studies showing a positive effect of intervention on psychological well‐being. Only two studies analyzed the association between the gut microbiome and psychological outcomes, each with a different pattern of results. As the field moves forward, it will be critical to gain a better understanding of the microbiome characteristics that influence mental health outcomes in pediatric populations.

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The microbiome in anti-cancer therapy

Cited by 60 publications

References 93 publications

Tumor Targeting by Fusobacterium nucleatum: A Pilot Study and Future Perspectives

Tumor Targeting by Fusobacterium nucleatum: A Pilot Study and Future Perspectives

Deficient Resident Memory T Cell and CD8 T Cell Response to Commensals in Inflammatory Bowel Disease

What can the gut microbiome teach us about the connections between child physical and mental health? A systematic review

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