The microbiome-gut-brain axis: implications for schizophrenia and antipsychotic induced weight gain

Kanji, Sarah; Fonseka, Trehani M.; Marshe, Victoria S.; Sriretnakumar, Venuja; Hahn, Margaret; Müller, Daniel J.

doi:10.1007/s00406-017-0820-z

Cited by 66 publications

(43 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The most recent data indicates that gastrointestinal homeostasis significantly affects the development and functioning of the central nervous system, which presents the so-called microbiota-gut-brain axis as the new paradigm in neuroscience [151]. Neuropsychiatric disorders where the etiopathology can be related to the gastrointestinal microbiota include anxiety, autism, anorexia nervosa, Parkinson's disease, Alzheimer's disease, ADHD, schizophrenia, alcohol dependence, bipolar disorders, or migraine pain [82,100,[152][153][154][155][156][157][158][159][160][161]. Interestingly, the microbiota-gut-brain axis starts to develop during the intrauterine period of fetal development.…”

Section: The Impact Of Gut Microbiota On the Cnsmentioning

confidence: 99%

Alterations in the Nervous System and Gut Microbiota after β-Hemolytic Streptococcus Group A Infection—Characteristics and Diagnostic Criteria of PANDAS Recognition

Baj

Sitarz

Forma

et al. 2020

IJMS

View full text Add to dashboard Cite

The objective of this paper is to review and summarize conclusions from the available literature regarding Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS). The authors have independently reviewed articles from 1977 onwards, primarily focusing on the etiopathology, symptoms, differentiation between similar psychiatric conditions, immunological reactions, alterations in the nervous system and gut microbiota, genetics, and the available treatment for PANDAS. Recent research indicates that PANDAS patients show noticeable alterations within the structures of the central nervous system, including caudate, putamen, globus pallidus, and striatum, as well as bilateral and lentiform nuclei. Likewise, the presence of autoantibodies that interact with basal ganglia was observed in PANDAS patients. Several studies also suggest a relationship between the presence of obsessive-compulsive disorders like PANDAS and alterations to the gut microbiota. Further, genetic predispositions—including variations in the MBL gene and TNF-α—seem to be relevant regarding PANDAS syndrome. Even though the literature is still scarce, the authors have attempted to provide a thorough insight into the PANDAS syndrome, bearing in mind the diagnostic difficulties of this condition.

show abstract

Section: The Impact Of Gut Microbiota On the Cnsmentioning

confidence: 99%

Alterations in the Nervous System and Gut Microbiota after β-Hemolytic Streptococcus Group A Infection—Characteristics and Diagnostic Criteria of PANDAS Recognition

Baj

Sitarz

Forma

et al. 2020

IJMS

View full text Add to dashboard Cite

show abstract

“…In this respect, an impaired gut microbiome inhibits the autophagy-mediated protein clearance process and a distinct gut microbiome composition can change the neurotransmitter levels in the brain through the vagal afferent fibers also pertinent for AD (Bostanciklioglu 2019). Current studies further evaluate gut microbiome-schizophrenia and mood disorder associations (Kanji et al 2018).…”

Section: Sniffing ɵMe (S)-cupmentioning

confidence: 97%

Microbiota changes associated with ADNP deficiencies: rapid indicators for NAP (CP201) treatment of the ADNP syndrome and beyond

et al. 2020

View full text Add to dashboard Cite

Activity-dependent neuroprotective protein (ADNP) and its protein snippet NAP (drug candidate CP201) regulate synapse formation and cognitive as well as behavioral functions, in part, through microtubule interaction. Given potential interactions between the microbiome and brain function, we now investigated the potential effects of the ADNP-deficient genotype, mimicking the ADNP syndrome on microbiota composition in the Adnp +/mouse model. We have discovered a surprising robust sexually dichotomized Adnp genotype effect and correction by NAP (CP201) as follows. Most of the commensal bacterial microbiota tested were affected by the Adnp genotype and corrected by NAP treatment in a male sex-dependent manner. The following list includes all the bacterial groups tested-labeled in bold are male Adnp-genotype increased and corrected (decreased) by NAP. (1) Eubacteriaceae (EubV3), (2) Enterobacteriaceae (Entero), (3) Enterococcus genus (gEncocc), (4) Lactobacillus group (Lacto), (5) Bifidobacterium genus (BIF), (6) Bacteroides/Prevotella species (Bac), (7) Clostridium coccoides group (Coer), (8) Clostridium leptum group (Cluster IV, sgClep), and (9) Mouse intestinal Bacteroides (MIB).No similarities were found between males and females regarding sex-and genotype-dependent microbiota distributions. Furthermore, a female Adnp +/genotype associated decrease (contrasting male increase) was observed in the Lactobacillus group (Lacto). Significant correlations were discovered between specific bacterial group loads and open-field behavior as well as social recognition behaviors. In summary, we discovered ADNP deficiency associated changes in commensal gut microbiota compositions, a sex-dependent biomarker for the ADNP syndrome and beyond. Strikingly, we discovered rapidly detected NAP (CP201) treatment-dependent biomarkers within the gut microbiota.Keywords Activity-dependent neuroprotective protein (ADNP) · Microbiota · NAP (CP201) · Behavior · Autism Electronic supplementary material The online version of this article (https ://doi.

show abstract

“…Research on the microbiome of individuals with ASD is the most advanced 142,143 and studies are now underway that are exploring the impact of microbiome transfer therapy 144 . Efforts to understand the role of the microbiome are also underway with regard to a number of other disorders including schizophrenia and bipolar disorder [145][146][147][148][149][150] , TS, OCD, and related disorders including PANS and PANDAS [151][152][153] , major depression and mood disorders 154,155 , alcohol use and eating disorders 156 , as well as neurodegenerative disorders 157 .…”

Section: The Microbiome Perinatal Nutrition and The 'Gut-brain Axis'mentioning

confidence: 99%

What does immunology have to do with brain development and neuropsychiatric disorders?

Leckman¹,

Alvarenga²,

Ravagnani³

et al. 2019

Rev. Med. (São Paulo)

View full text Add to dashboard Cite

Introduction: Neural development is an enormously complex and dynamic process. From very early in brain development ‘immune cells’ play a key role in a number of processes including the formation and refinement of neural circuits, as well as sexual differentiation. There is a growing body of evidence that the immune system also plays an important role in the pathobiology of several neurodevelopmental and neuropsychiatric disorders. Objective: The goal of this article is to review the currently available data concerning the role of the ‘immune system’ in normal brain development, as well as its role in the pathobiology of neurodevelopmental and neuropsychiatric disorders. Methodology: We conducted a traditional literature search using PubMed and recent special issues of journals to locate relevant review articles. Results: The cellular and molecular processes that make up our ‘immune system’ are crucial to normal brain development and the formation and maintenance of neural circuits. It is also increasingly evident that the immune system and neuroinflammation play important roles in the pathobiology of at least a subset of individuals with Autism Spectrum Disorder (ASD), schizophrenia, obsessive-compulsive disorder, Tourette syndrome and mood disorders, such as depression, as well as autoimmune and neurodegenerative disorders. Emerging evidence also points to the importance of the ‘gut-brain axis’ and an individual’s microbiome, which can impact an individual’s somatic and mental well-being. Conclusions: There are multidirectional interconnections across multiple biological systems in our brains and bodies that are mediated in part by the immune system. At present, however, the ‘promise’ of this field remains greater than the ‘deliverables.’ Time will tell whether novel interventions will be developed that will make a positive difference in the care of our patients. It is also possible that valid biomarkers will emerge that will guide a more personalized approach to treatment.

show abstract

The microbiome-gut-brain axis: implications for schizophrenia and antipsychotic induced weight gain

Cited by 66 publications

References 54 publications

Alterations in the Nervous System and Gut Microbiota after β-Hemolytic Streptococcus Group A Infection—Characteristics and Diagnostic Criteria of PANDAS Recognition

Alterations in the Nervous System and Gut Microbiota after β-Hemolytic Streptococcus Group A Infection—Characteristics and Diagnostic Criteria of PANDAS Recognition

Microbiota changes associated with ADNP deficiencies: rapid indicators for NAP (CP201) treatment of the ADNP syndrome and beyond

What does immunology have to do with brain development and neuropsychiatric disorders?

Contact Info

Product

Resources

About