The microbiome and rheumatoid arthritis

Bergot, Anne‐Sophie; Giri, Rabina; Thomas, Ranjeny

doi:10.1016/j.berh.2020.101497

Cited by 69 publications

(43 citation statements)

References 85 publications

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“…Dysbiosis, as defined above, is believed to contribute to the development of various immune-mediated conditions, including inflammatory bowel disease (IBD) ( 21 ), rheumatoid arthritis ( 32 ), type 1 diabetes mellitus ( 33 ), multiple sclerosis ( 34 ), and systemic lupus erythematosus (SLE) ( 35 ), among many others. IBD, which comprises of Crohn’s disease and ulcerative colitis, is a chronic inflammatory disease that is increasing in prevalence worldwide ( 36 ) and has been proposed to arise from an inappropriate mucosal inflammatory response to dysbiosis; this response is believed to be a result of genetic susceptibility and environmental exposure ( 37 ).…”

Section: Impact Of Microbiota On Healthmentioning

confidence: 99%

Unhealthy Lifestyle and Gut Dysbiosis: A Better Understanding of the Effects of Poor Diet and Nicotine on the Intestinal Microbiome

et al. 2021

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The study of the intestinal or gut microbiome is a newer field that is rapidly gaining attention. Bidirectional communication between gut microbes and the host can impact numerous biological systems regulating immunity and metabolism to either promote or negatively impact the host’s health. Habitual routines, dietary choices, socioeconomic status, education, host genetics, medical care and environmental factors can all contribute to the composition of an individual’s microbiome. A key environmental factor that may cause negative outcomes is the consumption of nicotine products. The effects of nicotine on the host can be exacerbated by poor dietary choices and together can impact the composition of the gut microbiota to promote the development of metabolic disease including non-alcoholic fatty liver disease. This review explores the contribution of nicotine, poor dietary choices and other unhealthy lifestyle factors to gut dysbiosis.

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Section: Impact Of Microbiota On Healthmentioning

confidence: 99%

Unhealthy Lifestyle and Gut Dysbiosis: A Better Understanding of the Effects of Poor Diet and Nicotine on the Intestinal Microbiome

et al. 2021

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“…They also found that age and geographic origin were connected to microbiota profiles (Van Dijkhuizen et al, 2019). In rheumatoid arthritis both oral and gut dysbiosis are well described and no consistent single bacterial species appears to be the causing agent (Bergot et al, 2020). Interestingly, periodonto-pathogenic bacteria such as Porphyromonas gingivalis have been suggested to contribute to generation of anti-citrullinated protein antibodies (ACPAs) in rheumatoid arthritis (Moen et al, 2006;Wegner et al, 2010a;Wegner et al, 2010b).…”

Section: Microbial Association To Disease Activitymentioning

confidence: 99%

Salivary Oral Microbiome of Children With Juvenile Idiopathic Arthritis: A Norwegian Cross-Sectional Study

Frid

Baraniya

Halbig

et al. 2020

Front. Cell. Infect. Microbiol.

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“…A T cell receptor transgenic murine model of inflammatory arthritis, the K/BxN scenario, offers straightforward discernment between the initiation and effector phases [ 49 ]. K/BxN T cell receptor transgenic mice present with inflammatory joint disease associated with elevated autoantibodies toward glucose-6-phosphate isomerase [ 50 ].…”

Section: Evidence From Animal Modelsmentioning

confidence: 99%

Role of Intestinal Microbiota on Gut Homeostasis and Rheumatoid Arthritis

Wang

2021

Journal of Immunology Research

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Rheumatoid arthritis (RA) is a chronic inflammatory disease that is immune mediated. Patients typically present with synovial inflammation, which gradually deteriorates to investigate severe cartilage and bone damage, affecting an individual’s ability to perform basic tasks and impairing the quality of life. When evaluated against healthy controls, patients with RA have notable variations within the constituents of the gut microbiota. The human gastrointestinal tract mucosa is colonized by trillions of commensal microbacteria, which are key actors in the initiation, upkeep, and operation of the host immune system. Gut microbiota dysbiosis can adversely influence the immune system both locally and throughout the host, thus predisposing the host to a number of pathologies, including RA. Proximal intestinal immunomodulatory cells, situated in specific locales within the intestine, are a promising intermediary through which the gastrointestinal microbiota can influence the pathogenesis and progression of RA. In the early stages of the disease, the microbiota appear to differ from those present in healthy controls. This difference may reflect potential autoimmune mechanisms. Research studies evaluating intestinal microbiota have demonstrated that RA is associated with a bacterial population growth or with a decline when judged against control groups. The aim of this review is to examine the studies that connect intestinal dysbiosis with the autoimmune pathways implicated in the pathogenesis of RA.

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The microbiome and rheumatoid arthritis

Cited by 69 publications

References 85 publications

Unhealthy Lifestyle and Gut Dysbiosis: A Better Understanding of the Effects of Poor Diet and Nicotine on the Intestinal Microbiome

Unhealthy Lifestyle and Gut Dysbiosis: A Better Understanding of the Effects of Poor Diet and Nicotine on the Intestinal Microbiome

Salivary Oral Microbiome of Children With Juvenile Idiopathic Arthritis: A Norwegian Cross-Sectional Study

Role of Intestinal Microbiota on Gut Homeostasis and Rheumatoid Arthritis

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