2017
DOI: 10.1101/125922
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The microbiome and metabolome of pre-term infant stool is personalized, and not driven by health outcomes including necrotizing enterocolitis and late-onset sepsis

Abstract: 12Background: The assembly of the intestinal microbiota of extremely low birthweight (ELBW) infants has 13 an important impact on both immediate and long term health. ELBW infants are frequently given 14 antibiotics which are likely to perturb the assembly of the microbiota. Health complications are not 15 uncommon for ELBW infants; they face health crises including sepsis and necrotizing enterocolitis (NEC). 16Microbes are thought to be involved in the pathogenesis of NEC, but the mechanisms are unclear. New … Show more

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Cited by 4 publications
(9 citation statements)
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“…However, these studies have mostly focused on adult populations with specific metabolic disease etiologies such as inflammatory bowel disease. Only a limited number of studies [ 18 – 23 ] have simultaneously profiled the gut microbiome and metabolome from infant stool samples. These studies have preliminarily established that metabolomic profiles shift as taxonomic abundances change between subject case/control status [ 18 , 20 , 21 , 24 ].…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…However, these studies have mostly focused on adult populations with specific metabolic disease etiologies such as inflammatory bowel disease. Only a limited number of studies [ 18 – 23 ] have simultaneously profiled the gut microbiome and metabolome from infant stool samples. These studies have preliminarily established that metabolomic profiles shift as taxonomic abundances change between subject case/control status [ 18 , 20 , 21 , 24 ].…”
Section: Introductionmentioning
confidence: 99%
“…Only a limited number of studies [ 18 – 23 ] have simultaneously profiled the gut microbiome and metabolome from infant stool samples. These studies have preliminarily established that metabolomic profiles shift as taxonomic abundances change between subject case/control status [ 18 , 20 , 21 , 24 ]. Specifically, Ayeni et al ( n = 48) [ 19 ] and Kisuse et al ( n = 35) [ 23 ] demonstrated that inter-sample distances calculated using metabolite abundances are correlated with those calculated from taxonomic profiles using Mantel tests across African and Asian cohorts.…”
Section: Introductionmentioning
confidence: 99%
“…However, these studies have mostly focused on adult populations with specific metabolic disease etiologies such as inflammatory bowel disease. Only a limited number of studies [18][19][20][21][22][23] have simultaneously profiled the gut microbiome and metabolome from infant stool samples. These studies have preliminarily established that metabolomic profiles shift as taxonomic abundances change between subject case/control status [18,20,21,24].…”
Section: Introductionmentioning
confidence: 99%
“…Only a limited number of studies [18][19][20][21][22][23] have simultaneously profiled the gut microbiome and metabolome from infant stool samples. These studies have preliminarily established that metabolomic profiles shift as taxonomic abundances change between subject case/control status [18,20,21,24]. Specifically, Ayeni et al (n = 48) [19] and Kisuse et al (n = 35) [23] demonstrated that inter-sample distances calculated using metabolite abundances are correlated with those calculated from taxonomic profiles using Mantel tests across African and Asian cohorts.…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation