The Microbiome and Host Behavior

Vuong, Helen E.; Yano, Jessica M.; Fung, Thomas C.; Hsiao, Elaine Y.

doi:10.1146/annurev-neuro-072116-031347

Cited by 421 publications

(315 citation statements)

References 99 publications

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“…Despite inconclusive findings, clinical data also suggests that the composition of the gut may be altered in the presence of disease, including those considered neurological. Endophenotypes have been observed linking microbial dysbiosis to an expanding list of CNS conditions that includes autism spectrum disorder, depression, and Parkinson's disease 82 .…”

Section: Gbmax: Linking the Gut And Neuroinflammationmentioning

confidence: 99%

The bidirectional gut-brain-microbiota axis as a potential nexus between traumatic brain injury, inflammation, and disease

Sundman

Chen

Subbian

et al. 2017

Brain, Behavior, and Immunity

140

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The bidirectional gut-brain-microbiota axis as a potential nexus between traumatic brain injury, inflammation, and disease. AbstractAs head injuries and their sequelae have become an increasingly salient matter of public health, experts in the field have made great progress elucidating the biological processes occurring within the brain at the moment of injury and throughout the recovery thereafter. Given the extraordinary rate at which our collective knowledge of neurotrauma has grown, new insights may be revealed by examining the existing literature across disciplines with a new perspective. This article will aim to expand the scope of this rapidly evolving field of research beyond the confines of the central nervous system (CNS). Specifically, we will examine the extent to which the bidirectional influence of the gut-brain axis modulates the complex biological processes occurring at the time of traumatic brain injury (TBI) and over the days, months, and years that follow. In addition to local enteric signals originating in the gut, it is well accepted that gastrointestinal (GI) physiology is highly regulated by innervation from the CNS. Conversely, emerging data suggests that the function and health of the CNS is modulated by the interaction between 1) neurotransmitters, immune signaling, hormones, and neuropeptides produced in the gut, 2) the composition of the gut microbiota, and 3) integrity of the intestinal wall serving as a barrier to the external environment. Specific to TBI, existing pre-clinical data indicates that head injuries can cause structural and functional damage to the GI tract, but research directly investigating the neuronal consequences of this intestinal damage is lacking. Despite this void, the proposed mechanisms emanating from a damaged gut are closely implicated in the inflammatory processes known to promote neuropathology in the brain following TBI, which suggests the gut-brain axis may be a therapeutic target to reduce the risk of Chronic Traumatic Encephalopathy and other neurodegenerative diseases following TBI. To better appreciate how various peripheral influences are implicated in the health of the CNS following TBI, this paper will also review the secondary biological injury mechanisms and the dynamic pathophysiological response to neurotrauma. Together, this review article will attempt to connect the dots to reveal novel insights into the bidirectional influence of the gut-brain axis and propose a conceptual model relevant to the recovery from TBI and subsequent risk for future neurological conditions.

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Section: Gbmax: Linking the Gut And Neuroinflammationmentioning

confidence: 99%

The bidirectional gut-brain-microbiota axis as a potential nexus between traumatic brain injury, inflammation, and disease

Sundman

Chen

Subbian

et al. 2017

Brain, Behavior, and Immunity

140

View full text Add to dashboard Cite

show abstract

“…Some of the strongest evidence in that domain comes from germ‐free animal models. These models demonstrate that an absence of bacteria in early life, but not later in development, alters the maturation of several brain regions with known importance for emotional health, such as the amygdala, hippocampus, ventral striatum, and prefrontal cortex (Vuong et al, ). In other words, there appears to be a sensitive period in early life during which bacteria need to be present for brain development to proceed along a typical trajectory.…”

Section: Two Important Developmental Concepts: ‘Expected Environmentamentioning

confidence: 99%

Commentary: Microbial panaceas: does development have the answer? – reflections on Cowan, Dinan, & Cryan (2020)

Callaghan

2020

Child Psychology Psychiatry

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“…Although research on microbial influence on animal social behaviour is vibrant and emergent, with much being discovered every year, most mechanistic pathways (e.g., neurophysiological) are unclear or unknown (see Vuong et al., ). Furthermore, the focus of such studies has been mammalian models (reviewed by Pascoe, Hauffe, Marchesi, & Perkins, ).…”

Section: The Gut–brain Axis and Its Importance For Health Stress Phymentioning

confidence: 99%

Using fish models to investigate the links between microbiome and social behaviour: The next step for translational microbiome research?

et al. 2019

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Recent research has revealed surprisingly important connections between animals’ microbiome and social behaviour. Social interactions can affect the composition and function of the microbiome; conversely, the microbiome affects social communication by influencing the hosts’ central nervous system and peripheral chemical communication. These discoveries set the stage for novel research focusing on the evolution and physiology of animal social behaviour in relation to microbial transmission strategies. Here, we discuss the emerging roles of teleost fish models and their potential for advancing research fields, linked to sociality and microbial regulation. We argue that fish models, such as the zebrafish (Danio rerio, Cyprinidae), sticklebacks (‎Gasterosteidae), guppies (Poeciliidae) and cleaner–client dyads (e.g., obligate cleaner fish from the Labridae and Gobiidae families and their visiting clientele), will provide valuable insights into the roles of microbiome in shaping social behaviour and vice versa, while also being of direct relevance to the food and ornamental fish trades. The diversity of fish behaviour warrants more interdisciplinary research, including microbiome studies, which should have a strong ecological (field‐derived) approach, together with laboratory‐based cognitive and neurobiological experimentation. The implications of such integrated approaches may be of translational relevance, opening new avenues for future investigation using fish models.

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The Microbiome and Host Behavior

Cited by 421 publications

References 99 publications

The bidirectional gut-brain-microbiota axis as a potential nexus between traumatic brain injury, inflammation, and disease

The bidirectional gut-brain-microbiota axis as a potential nexus between traumatic brain injury, inflammation, and disease

Commentary: Microbial panaceas: does development have the answer? – reflections on Cowan, Dinan, & Cryan (2020)

Using fish models to investigate the links between microbiome and social behaviour: The next step for translational microbiome research?

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