The microbiome and chronic rhinosinusitis

Sivasubramaniam, Rahuram; Douglas, Richard

doi:10.1016/j.wjorl.2018.08.004

Cited by 30 publications

(33 citation statements)

References 79 publications

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“…Numerous studies have identified the pathogens associated with CRS, including Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes. Haemophilus influenzae , and Moraxella catarrhalis , which differ from healthy nasal flora [ 3 , 4 ]. However, reports of the oral microbiome in CRS are scarce.…”

Section: Discussionmentioning

confidence: 99%

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Clinical Detection of Chronic Rhinosinusitis through Next-Generation Sequencing of the Oral Microbiota

et al. 2020

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Chronic rhinosinusitis (CRS) is the chronic inflammation of the sinus cavities of the upper respiratory tract, which can be caused by a disrupted microbiome. However, the role of the oral microbiome in CRS is not well understood. Polymicrobial and anaerobic infections of CRS frequently increased the difficulty of cultured and antibiotic therapy. This study aimed to elucidate the patterns and clinical feasibility of the oral microbiome in CRS diagnosis. Matched saliva and nasal swabs were collected from 18 CRS patients and 37 saliva specimens from normal volunteers were collected for 16S rRNA sequencing. The α-diversity of the saliva displayed no significant difference between control and CRS patients, whereas the β-diversity was significantly different (p = 0.004). Taxonomic indices demonstrated that Veillonella dispar, Rothia mucilaginosa, and Porphyromonas endodontalis were enriched, while Campylobacter and Cardiobacterium were reduced in the saliva of CRS patients. These microbial markers could significantly distinguish CRS patients from control (AUC = 0.939). It is noted that the 16S rRNA results of the nasal swab were consistent with the nasopharynx aerobic culture, and additionally detected multiple pathogens in CRS patients. In summary, these results indicated these oral microbiomes may provide a novel signal for CRS detection and that NGS may be an alternative approach for CRS diagnosis.

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Section: Discussionmentioning

confidence: 99%

“…When the number of polyps is too many or they become too large, they will further block the nasal cavity, preventing normal mucus discharge and worsening the infection. Until now, the therapeutic approach for CRS has been treatment with antibiotics, corticosteroids, saline lavage, and surgery [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Clinical Detection of Chronic Rhinosinusitis through Next-Generation Sequencing of the Oral Microbiota

et al. 2020

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“…Chronic rhinosinusitis (CRS) is a multifactorial chronic upper airway inflammatory disease. Putative pathological factors include changes in the microbiota, an imbalance of the local or systemic immune system, allergens, toxins, and genetic predisposition 1 – 3 . Several studies have reported that the microbiota may affect the pathophysiology of CRS.…”

Section: Introductionmentioning

confidence: 99%

Association between the sinus microbiota with eosinophilic inflammation and prognosis in chronic rhinosinusitis with nasal polyps

Kim

Lim

et al. 2020

Exp Mol Med

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Dysbiosis of the sinus microbiome affects the pathophysiology of chronic rhinosinusitis with nasal polyps (CRSwNPs). We investigated whether the sinus microbiota in CRSwNPs is associated with eosinophilic inflammation, especially in relation to innate lymphoid cells (ILCs), prognosis, and serum extracellular vesicles (EVs). Middle meatal swabs and serum from 31 CRSwNPs patients and six healthy controls were analyzed by 16S ribosomal RNA sequencing. ILC2s and cytokines from sinonasal tissues were measured by flow cytometry and ELISA, respectively. The relative abundances (RAs) of bacteria were compared based on eosinophilic inflammation and surgical outcome. The correlations between sinus bacteria and ILC2s, cytokines, and serum EVs were analyzed. The compositions of sinus bacteria were different between groups at the genus level. In eosinophilic CRSwNPs patients, the RA of Anaerococcus was significantly decreased ( P = 0.010), whereas that of Lachnoclostridium was significantly increased ( P = 0.038) compared with that in controls. The RA of Lachnoclostridium showed a significant positive correlation with interleukin (IL)-5-producing ILC2 populations ( R = 0.340, P = 0.049), whereas the RA of Anaerococcus showed a negative correlation with IL-5-producing ILC2 populations ( R = −0.332, P = 0.055). The RAs of Corynebacterium , Anaerococcus , and Tepidimonas were significantly decreased in patients with suboptimal outcomes compared with those in patients with optimal outcomes and control subjects. Some sinus bacteria and serum EVs showed positive correlations. CRSwNPs patients showed distinct microbiota compositions based on eosinophilic inflammation in relation to ILC2s and surgical outcome. These findings support a relationship between the microbiota and the host immune response in CRSwNPs.

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“…Purulent nasal discharge (anterior or posterior or both) is not only a diagnostic criterion of CRS but also one of the most common symptoms that make CRS patients uncomfortable. Although microbiome studies have reported various organisms and their important roles in the pathophysiology of CRS [3], the selection of antibiotics for infectious exacerbations in CRS patients is recommended to follow the results of bacterial culture, ideally endoscopically guided culture [1,4]. Antibiotics for CRS in South Korea have been abused (e.g., by being prescribed in the absence of culture data), fueling concerns about the emergence of atypical bacterial strains and antibiotic-resistant strains.…”

Section: Introductionmentioning

confidence: 99%

Recent Trends in Bacteriology of Adult Patients with Chronic Rhinosinusitis

Kim

Assiri

Kim

2019

JCM

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This study aimed to identify trends in bacteria isolated from Korean adults with chronic rhinosinusitis (CRS). Enrolled were CRS patients who underwent sinus bacterial culture during endoscopic sinus surgery between 2007–2008, 2011–2012, and 2017–2018 (n = 510). Patients’ clinical characteristics, bacterial culture results, and antibiotic resistance were reviewed. The bacteria isolation rate was 76.3% (73.9% for CRS with nasal polyps and 82.8% for CRS without nasal polyps; p = 0.038). In total, 650 strains were isolated, the most common was Coagulase Negative Staphylococci (CNS) (28.0%), followed by Streptococcus species (12.2%), Propionibacterium species (8.0%), Corynebacterium species (7.5%), Staphylococcus aureus (6.2%), Haemophilus species (5.7%), Klebsiella species (5.1%), and Pseudomonas aeruginosa (4.2%). Furthermore, an analysis of the bacterial trends in the three groups showed significant increases over time for the isolation of CNS (p = 0.006), Klebsiella (p = 0.002), and P. aeruginosa (p = 0.007) and extended-spectrum beta-lactamase (ESBL) producing Klebsiella (p < 0.001) and Enterobacter (p = 0.007) species in terms of antibiotics resistance. This study demonstrates that the frequency of CNS, Klebsiella, and P. aeruginosa in CRS patients and the ESBL-producing Klebsiella and Enterobacter species has significantly increased in CRS patients over the last decade.

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The microbiome and chronic rhinosinusitis

Cited by 30 publications

References 79 publications

Clinical Detection of Chronic Rhinosinusitis through Next-Generation Sequencing of the Oral Microbiota

Clinical Detection of Chronic Rhinosinusitis through Next-Generation Sequencing of the Oral Microbiota

Association between the sinus microbiota with eosinophilic inflammation and prognosis in chronic rhinosinusitis with nasal polyps

Recent Trends in Bacteriology of Adult Patients with Chronic Rhinosinusitis

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