The microbiological determination of proline, cystine, and isoleucine

Heller, Gershon L.; Kirch, Ernst R.

doi:10.1002/jps.3030361107

Cited by 7 publications

(2 citation statements)

References 19 publications

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“…Moreover, this vital nutrition is a strong antioxidant that acts as an energy reservoir in the cells which adjust the cellular reduction potential. Protection of super molecules like proteins and decreasing the internal acidity of the cells are other functions of proline [2][3][4]. This amino acid which is the precursor of hydroxyl proline in our body is one of the principal constituents of collagen.…”

Section: Graphical Abstractmentioning

confidence: 99%

Evaluating Adsorption of Proline Amino Acid on the Surface of Fullerene (C60) and Carbon Nanocone by Density Functional Theory

2020

Chem. Methodol.

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Determination of proline is of great importance and investigating the interaction of this amino acid with nanostructures play a key role in the construction of novel appropriate sensors for proline measurement. In this regard, proline adsorption on the surface of fullerene and carbon nanocone was studied by density functional theory. For this purpose, the structures of fullerene, nanocone, proline and proline-adsorbent complexes at two different configurations were optimized geometrically. Then, IR and Frontier molecular orbital calculations were done in the temperature range of 298.15-398.15 K at 10˚ intervals. The obtained adsorption energies, adsorption enthalpy changes, Gibbs free energy variations and thermodynamic equilibrium constants showed that the adsorption of proline on the surface of nanocone is exothermic, spontaneous, one sided and experimentally feasible. In this sense, proline adsorption on the fullerene is endothermic, non-spontaneous, balanced and experimentally impossible. The achieved specific heat capacity values reveal that carbon nanocone can be used in the development of thermal sensors for the determination of proline. The effect of temperature on the adsorption process was also checked out and the results indicate that 298.15 is the optimum temperature for the studied procedure. Some HOMO-LUMO parameters such as energy gap, electrophilicity, maximum charge capacity, chemical hardness and chemical potential were also evaluated. Accordingly, the findings demonstrate that carbon nanocone can be utilized in the electrochemical determination of proline.

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Section: Graphical Abstractmentioning

confidence: 99%

Evaluating Adsorption of Proline Amino Acid on the Surface of Fullerene (C60) and Carbon Nanocone by Density Functional Theory

2020

Chem. Methodol.

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“…Figure 1.B represents its structure. In the cell cycle in S phase, as a competitive inhibitor of the DNA polymerase enzyme, it rapidly is converted to Cytosine triphosphate and, since cells needs the DNA replication to be divided, DNA natural replication is disrupted through inhibiting the mitosis [4]. Of course there are many side effects including: nausea and digestive problems such as headache, dizziness, skin rash, hair loss, itching, difficulty in swallowing, abdominal pain, anal wounds, infancy, etc.…”

Section: Original Research Articlementioning

confidence: 99%

Untitled

2020

Eurasian Chem. Commun.

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In this study, the adsorption of Cytarabine on the surface of C20 was evaluated by density functional theory. At first, the structures of fullerene, drug, and their complexes were optimized, geometrically. Then, IR and frontier molecular orbital computations were performed on them in the vacuum and aqueous phase. The calculated adsorption energies, Gibbs free energy changes (ΔGad) and adsorption enthalpy changes (ΔHad) revealed that the adsorption process of Cytarabine is experimentally feasible, spontaneous, exothermic and non-equilibrium. The effect of temperature on the adsorption process was also checked out and the results indicated that the optimum temperature for the interaction of fullerene with the drug is 298 ˚K. The frontier molecular orbital parameters such as band gap, chemical hardness, electrophilicity, chemical potential, and charge capacity were also studied and the results proved that C20 is an ideal electroactive sensing material for fabricating novel sensors for determination of Cytarabine. The values of dipole moment have also revealed that the bioavailability and biocompatibility of the drug have also improved after adsorbing on the surface of fullerene.

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