The microbial epidemiology of trachoma

Treharne, J D

doi:10.1007/bf00133777

Cited by 9 publications

(2 citation statements)

References 23 publications

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“…Prouzrokovan je serotipovima A, B, Ba i C Chlamydia trachomatis [2]. Bolest se karakteriše pojavom folikula, papilarne hiperplazije i panusom a u kasnijim stadijumima ožiljcima [3].…”

Section: Uvodunclassified

Chlamydia trachomatis as a cause of trachoma

Maric¹,

Đukić²

2015

Praxis Med

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Trahom (Trachoma) je specifični zarazni keratokonjunktivitis prouzrokovan serotipovima A, B, Ba i C Chlamydia trachomatis. Trahom predstavlja najčešći uzrok preventibilnog slepila u svetu pored katarakte i glaukoma. Oko 84 miliona ljudi ima aktivni trahom, 7,6 miliona ljudi sa neoperisanom i netretiranom trihijazom trpi posledice trahoma a 1,3 miliona ljudi je slepo. Danas je prihvaćena klasifikacija Svetske zdravstvene organizacije (SZO) koja koristi gradiranje na osnovu prisustva ili odsutva 5 kliničkih znakova. SZO ima program za eradikaciju slepila u svetu do 2020. godine koji se zove "Pravo na vid". U okviru tog programa nalazi se i program za eradikaciju trahoma u svetu, takozvana SAFE strategija. Ona podrazumeva hiruršku korekciju komplikacija kod trahoma (S-surgery), primenu antibiotika (A-antibiotic), higijenu lica (F-face) i rad na poboljšanju socijalno-ekonomskih i higijenskih uslova života (E-education). Lečenje trahoma sprovodi se lokalnom i sistemskom primenom odgovarajućih antibiotika. Komplikacije trahoma kao što je trihijaza rešavaju se hirurškom korekcijom i na taj način sprečavaju pojavu kornealnih zamućenja i dodatni gubitak vida. SUMMARYITrachoma is keratoconjunctivitis caused by ocular infection with Chlamydia trachomatis. Endemic trachoma is caused by serovars A, B, Ba and C. Trachoma is probably the third most common cause of blindness worldwide, after cataracta and glaucoma. Active trachoma affects an estimated 84 million people; another 7.6 million have end-stage disease, of which about 1.3 million are blind. Most trachoma programmes use the WHO simplified grading system, by presence or absence of five clinical signs. The World Health Organization is leading a global effort to eliminate blinding trachoma by the year 2020, through the implementation of the SAFE strategy. This involves surgery for trichiasis (S-surgery), antibiotics for infection (A-antibiotic), facial cleanliness (F-face) and environmental improvements to reduce transmission of the organism (Eeducation). Tratment for trachoma includes local and systemic administration of appropriate antibiotics. Surgical correction of trachomatous trichiasis reduces the risk of progressive corneal opacification and blindness.

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“…Prouzrokovan je serotipovima A, B, Ba i C Chlamydia trachomatis [2]. Bolest se karakteriše pojavom folikula, papilarne hiperplazije i panusom a u kasnijim stadijumima ožiljcima [3].…”

Section: Uvodunclassified

Chlamydia trachomatis as a cause of trachoma

Maric¹,

Đukić²

2015

Praxis Med

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“…Small studies conducted in Taiwan and Iran in the 1970s and 1980s, which used the micro-immunofluorescence test to type ocular isolates or tear antibody, showed that a single serovar of C. trachomatis usually accounts for all infections in any given household, confirming the importance of transmission within the family. 34,35 Molecular genotyping, usually performed by sequencing the ompA gene after its amplification by a PCR, has enabled us to conduct much larger studies. These investigations have generally confirmed that a single household contains a single genotype, that more than one genotype is present in most if not all trachoma-endemic communities, and that single nucleotide polymorphisms are commonly found in ocular strains.…”

Section: Molecular Toolsmentioning

confidence: 99%

Application of Molecular Tools in the Control of Blinding Trachoma

Mabey

Solomon

2003

The American Journal of Tropical Medicine and Hygiene

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Abstract. The use of anti-chlamydial antibiotics for trachoma control is based on the assumption that most people with clinically active disease have conjunctival infection with Chlamydia trachomatis. In high prevalence areas, this is generally true. As prevalence decreases, however, the positive predictive value of clinical signs for C. trachomatis infection also decrease. In this paper, the case for using laboratory assays to guide trachoma control strategies is presented, molecular methods for diagnosis (such as a ligase chain reaction and a polymerase chain reaction [PCR]) are compared with earlier techniques, and recent findings of ongoing studies using a quantitative PCR are reviewed. In addition, the contribution of genotyping to our understanding of the epidemiology and biology of C. trachomatis is considered.

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Trachoma

Burton¹

2010

Essentials in Ophthalmology

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The microbial epidemiology of trachoma

Cited by 9 publications

References 23 publications

Chlamydia trachomatis as a cause of trachoma

Chlamydia trachomatis as a cause of trachoma

Application of Molecular Tools in the Control of Blinding Trachoma

Trachoma

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