The Microanatomy of Trabecular Bone Loss in Normal Aging Men and Women

Aaron, Jean E.; Makins, Naomi B.; Sagreiya, K

doi:10.1097/00003086-198702000-00038

Cited by 363 publications

(124 citation statements)

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“…This has also been reported after corticosteroid therapy in humans and rats [6,26]. In contrast there was thinning as well as wholesale loss of trabeculae (and hence connectivity) in the proximal femur, more like the situation observed in postmenopausal osteoporosis [1]. We speculate on the basis of these findings that the mechanism of bone loss at the tissue level could differ not only with duration of treatment but also between different skeletal sites.…”

Section: Discussionsupporting

confidence: 78%

Validation of the sheep as a large animal model for the study of vertebral osteoporosis

Zarrinkalam¹,

Beard²,

Schultz

et al. 2008

Eur Spine J

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Rats have long been the animal of choice for research in the field of osteoporosis. In the search for a complementary large animal model the sheep appears useful but hitherto the extent of bone loss from the spine has failed to reach a level that is generally accepted as osteoporotic in humans. Osteoporosis was induced in ten sheep using ovariectomy, low calcium diet and steroid injection for 6 months. Bone samples of iliac crest (IC), lumbar spine (LS), and proximal femur (PF) from the osteoporotic sheep were compared with those from four normal sheep using densitometry, histomorphometry, biochemistry and basic mechanical testing. The differences were examined using an analysis of variance with Tukey-Kramer test. Overall, the bone mineral density at LS and PF decreased more than 25% after treatment. Trabecular bone volume decreased by 29.2, 33.4 and 42.6% in IC, LS and PF, respectively. The failure load of the LS in axial compression was reduced to 2,003 from 6,140 N. The extent of bone loss was sufficient to categorise these sheep as osteoporotic although the pattern of bone loss varied between sites. Reduced mechanical competence in LS confirmed the suitability of this model for evaluation of potential treatments for osteoporosis.

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Section: Discussionsupporting

confidence: 78%

Validation of the sheep as a large animal model for the study of vertebral osteoporosis

Zarrinkalam¹,

Beard²,

Schultz

et al. 2008

Eur Spine J

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“…Of note, when TBS is derived from DXA images obtained in GE-Lunar densitometers, TBS appears to be lower in men than in women, which is surprising given the previous observations of better trabecular microarchitecture in aging men than in women by histomorphometry and HRpQCT (53,54).…”

Section: Conclusion -Trabecular Bone Score: Facts and Futurementioning

confidence: 77%

Trabecular bone score: perspectives of an imaging technology coming of age

Silva

Bilezikian

2014

Arq Bras Endocrinol Metab

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The trabecular bone score (TBS) is a new method to describe skeletal microarchitecture from the dual energy X-ray absorptiometry (DXA) image of the lumbar spine. While TBS is not a direct physical measurement of trabecular microarchitecture, it correlates with micro-computed tomography (µCT) measures of bone volume fraction, connectivity density, trabecular number, and trabecular separation, and with vertebral mechanical behavior in ex vivo studies. In human subjects, TBS has been shown to be associated with trabecular microarchitecture and bone strength by high resolution peripheral quantitative computed tomography (HRpQCT). Cross--sectional and prospective studies, involving a large number of subjects, have both shown that TBS is associated with vertebral, femoral neck, and other types of osteoporotic fractures in postmenopausal women. Data in men, while much less extensive, show similar findings. TBS is also associated with fragility fractures in subjects with secondary causes of osteoporosis, and preliminary data suggest that TBS might improve fracture prediction when incorporated in the fracture risk assessment system known as FRAX. In this article, we review recent advances that have helped to establish this new imaging technology. Arq Bras Endocrinol Metab. 2014;58(5):493-503 Keywords Trabecular bone score; osteoporosis; fracture risk; bone mineral density; microarchitecture RESUMO TBS (do inglês, "trabecular bone score") é um novo método que estima a microarquitetura óssea a partir de uma imagem de densitometria óssea (DXA) da coluna lombar. Apesar de o TBS não ser uma medida física direta da microarquitetura trabecular, ele correlaciona-se com o volume ósseo, densidade da conectividade trabecular, número de trabéculas e separação trabecular medidos por microtomografia computadorizada (µCT), e com medidas mecânicas da resistência óssea vertebral em estudos ex vivo. Estudos em humanos confirmaram que o TBS associa-se a microarquitetura trabecular e resistência óssea medidas por tomografia computadorizada quantitativa periférica de alta resolução (HRpQCT). Estudos transversais e prospectivos, envolvendo um grande número de indivíduos, mostraram que o TBS é associado com fratura vertebral, de colo de fêmur e com outros tipos de fraturas osteoporóticas em mulheres na pós-menopausa. Dados em homens, apesar de escassos, mostram resultados semelhantes. Além disso, o TBS foi associado a fraturas por fragilidade em indivíduos com diversas causas secundárias de osteoporose e, dados preliminares, sugerem que o uso do TBS pode melhorar a previsão de fratura quando incorporado ao sistema de avaliação de risco de fratura (FRAX). Este artigo faz uma revisão de avanços recentes que têm ajudado a estabelecer esse novo mé-todo de imagem. Arq Bras Endocrinol Metab. 2014;58(5):493-503 Descritores

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“…(6)(7)(8)(9) In the crosssectional study of a sample of the Rochester, MN, population, men had decreasing trabecular thickness with age, whereas in women the trabecular number diminished, (9) as previously observed with histomorphometry of iliac crest biopsies. (10) The improvements in resolution of 3D imaging have made possible the use of micro-finite element analysis (mFEA) in order to assess quantitatively the biomechanical properties that result from the bone microarchitecture. (11)(12)(13) We have shown in previous casecontrol fracture studies conducted in women that HR-pQCT images of radius and tibia could be used to determine microarchitecture (14) and-in combination with mFEA-biomechanical parameters that were associated with prevalent fracture.…”

Section: Introductionmentioning

confidence: 99%

Finite element analysis performed on radius and tibia HR-pQCT images and fragility fractures at all sites in men

Vilayphiou

Boutroy

Szulc

et al. 2010

Journal of Bone and Mineral Research

126

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Few studies have investigated bone microarchitecture and biomechanical properties in men. This study assessed in vivo both aspects in a population of 185 men (aged 71 AE 10 years) with prevalent fragility fractures, compared to 185 controls matched for age, height, and weight, from the Structure of the Aging Men's Bones (STRAMBO) cohort.In this case-control study, areal BMD (aBMD) was measured by DXA, bone microarchitecture was assessed by high resolution (HR)-pQCT, and finite element (mFE) analysis was based on HR-pQCT images of distal radius and tibia. A principal component (PC) analysis (PCA) was used to study the association of synthetic PCs with fracture by computing their odds ratio (OR [95%CI]) per SD change. Specific associations with vertebral fracture (n ¼ 100), and nonvertebral fracture (n ¼ 85) were also computed.At both sites, areal and volumetric BMD, cortical thickness and trabecular number, separation, and distribution were significantly worse in cases than in controls, with differences ranging from À6% to 15%. mFE-derived stiffness and failure load were 8% to 9% lower in fractures ( p < .01). No difference in load distribution was found between the two groups. After adjustment for aBMD, only differences of mFE-derived stresses, stiffness, and failure load at the tibia remained significant ( p < .05).PCA resulted in defining 4 independent PCs, explaining 83% of the total variability of bone characteristics. Nonvertebral fractures were associated with PC1, reflecting bone quantity and strength at the radius (tibia) with OR ¼

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The Microanatomy of Trabecular Bone Loss in Normal Aging Men and Women

Cited by 363 publications

References 0 publications

Validation of the sheep as a large animal model for the study of vertebral osteoporosis

Validation of the sheep as a large animal model for the study of vertebral osteoporosis

Trabecular bone score: perspectives of an imaging technology coming of age

Finite element analysis performed on radius and tibia HR-pQCT images and fragility fractures at all sites in men

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