The MHC of a broiler chicken line: serology, B-G genotypes, and B-F/B-LB sequences

Li, Lanqing; Johnson, L. W.; Livant, Emily J.; Ewald, Sandra J.

doi:10.1007/s002510050482

Cited by 36 publications

(41 citation statements)

References 19 publications

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“…Thus,`standard' haplotypes are almost all derived from the White Leghorn. However, preliminary typing of other (indigenous) breeds of chickens, and of wild chickens, indicates the existence of a much wider spectrum of allomorphs (Simonsen et al, 1982) and reveals new alleles, often with distinct haplotypes (Hepkema et al, 1991;Briles et al, 1993;Li et al, 1999;Livant et al, 2001). Since each class of MHC genes is a potential candidate for a role in disease resistance (Nordskog et al, 1987;Lamont, 1998a) and immune response (Fulton et al, 1996), knowledge of the B system of poultry should not be limited to White Leghorns.…”

Section: Introductionmentioning

confidence: 99%

Serological Screening for MHC (B)-Polymorphism in Indigenous Chickens

Baelmans

Parmentier

Nieuwland

et al. 2005

Tropical Animal Health and Production

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As part of a series of studies to characterize innate and speci¢c immune responses of indigenous chicken lines, birds from Bolivia and India were screened serologically for MHC class IV (BG) polymorphism by direct haemagglutination using haplotype-speci¢c antisera (B2, B4, B12, B13, B14, B15, B19, B21). The sample consisted of 95 Bolivian indigenous chickens and 119 hens from the four most common North Indian`back-yard' chicken lines: Yellow Aseel (AP), Kadaknath (KN), frizzled typed (Ff^) and naked neck (NN). Of all chickens tested, the majority were haplotyped as B2, B15, B19 and B21. Of the Bolivian chickens, 89.5% could be haplotyped: 54.9% were homozygous (including 43.3% B15), and 34.6% were heterozygous (including 15.7% B15). B2-like haplotypes were not found among the Bolivian hens, and only 3.2% of these birds showed homozygous B21-like proteins. Of the Indian hens, MHC (BG)-like proteins could be detected in 60.0% of the AP birds, 6.7% of the KN birds; 40.0% of the Ff^birds; and 10.3% of the NN birds. In these lines, a total of 40.1% (AP), 6.7% (KN), 30.1% (Ff^) and 10.3% (NN) were homozygous for the B-haplotype. Only in the AP line (19.9%), and the Ff^line (9.9%) were heterozygous B-haplotypes types found. The B2 haplotype was found in all Indian chicken lines. Most Indian birds have completely unknown haplotypes, indicating a potentially interesting genetic pool. Subgrouping the Bolivian and Indian indigenous hens into monomorphic BG populations revealed individual di¡erences based on the B-types.

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Section: Introductionmentioning

confidence: 99%

Serological Screening for MHC (B)-Polymorphism in Indigenous Chickens

Baelmans

Parmentier

Nieuwland

et al. 2005

Tropical Animal Health and Production

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“…Alternatively, the current data indicate that one could select for chickens with the B*15 haplotype to increase resistance to IBV. Indeed, the resistant B*15 haplotype is prevalent in both egg-laying and broiler chicken strains (Briles & Briles, 1982;Li et al, 1999). However, it is unlikely selection for a resistant B haplotype (e.g.…”

Section: Discussionmentioning

confidence: 99%

Retrospective evidence that the MHC (B haplotype) of chickens influences genetic resistance to attenuated infectious bronchitis vaccine strains in chickens

Bacon

Hunter²,

Zhang

et al. 2004

Avian Pathology

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Infectious bronchitis is a respiratory disease of chickens that is caused by the coronavirus infectious bronchitis virus (IBV). Virtually all broiler and layer breeder flocks are routinely vaccinated against IBV. Two hatches of 1-day-old chicks from four lines were mistakenly vaccinated for infectious bronchitis using a moderately attenuated vaccine designed for chicks of an older age. The vaccination resulted in high mortality, and chicks from three of four lines died with signs typical of infectious bronchitis. The mortality that occurred using this less-attenuated vaccine was significantly influenced by the genetic line, and the MHC (B) haplotype in chickens of three B congenic lines. B congenic chickens possessing the B*15 haplotype were resistant in contrast to chickens possessing the B*13 or B*21 haplotypes. Chicks from two further hatches of the four lines were vaccinated appropriately with a more attenuated IBV vaccine, and only limited chick mortality was seen. These retrospective data from two repeated hatches confirm earlier data indicating chicken genes influence resistance to IBV, and indicate for the first time that genes tightly linked to the B haplotype are relevant in resistance to IBV. Due to extenuating circumstances it was not possible to verify results with chicks from F 2 matings. Factors that may enhance definition of the role of the B haplotype in immune response to IBV, and the desirability for further analysis of a B haplotype-linked influence on immunity to IBV are discussed.

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“…It was shown by Li et al (1999) . For the purpose of the present report, the standard Leghorn nomenclature will be used in place of those two designations.…”

Section: Serotypingmentioning

confidence: 94%