The MG-QOL15 Japanese version: validation and associations with clinical factors

Abstract

We produced a Japanese translation of the 15-item myasthenia gravis (MG)-specific quality of life (QOL) scale (MG-QOL15), assessed its reliability and validity, and examined clinical factors affecting the self-perceived QOL in MG. Consecutive 327 patients with MG seen at six neurological centers were evaluated. All patients completed an MG-QOL15 Japanese version (MG-QOL15-J), the Beck Depression Inventory-Second Edition (BDI-II), and a generic health-related QOL questionnaire, the SF-36. Disease severity was determined according to the MG Foundation of America (MGFA) quantitative MG score and the MG composite. The MG-QOL15-J exhibited adequate internal reliability, test-retest repeatability, and concurrent validity with SF-36, disease severity, and known-patient groups categorized by MGFA postintervention status. Multivariate analysis revealed severity, dose of oral corticosteroids, and BDI-II as independent factors negatively affecting QOL. The MG-QOL15-J is anticipated to be a valuable clinical measure of QOL in Japanese patients with MG.

Validation of the 15‐item myasthenia gravis quality of life questionnaire (MG‐QOL15) Persian version

“…Because there is no MG‐specific measure of quality of life in Persian, we decided to evaluate the MG‐QOL15 validity and reliability in Iranian patients. The Persian MG‐QOL15 revealed acceptable internal consistency, test–retest reproducibility, and concurrent and construct validity, as in previous studies . The total MG‐QOL15 scores in our patients were lower than reported by Burns et al, and, furthermore, the correlation of each SF‐36 domain with the MG‐QOL15 was higher in our study in comparison with the results of previous studies .…”

Brazilian cross-cultural translation and adaptation of the "Questionnaire of Life Quality Specific for Myasthenia Gravis - 15 items"

“…more symptoms and incapacity attributed to the disease), the worse the perception of the general health status by the patient. This is in line with the results of the other two studies with the MG-QOL15 12,17 . Indeed the frequency and severity of MG symptoms are wellknown factors that influence the patient's perception of his/her quality of life 15,12 .…”

Oral corticosteroid therapy and present disease status in myasthenia gravis

“…Achievement of CSR is uncommon, even today, and the situation has not improved substantially since the 1940s . Rather than achievement of CSR, achievement of MM would be appropriate as a practical goal of MG therapy . Therefore, the patients in the PSL group were subdivided into 2 groups: the “MM or better” group, including CSR, PR, and MM; and the “I or worse” group, including I, U, W, and E. Comparisons between the 2 groups using the Mann‐Whitney U ‐test and the Pearson chi‐square test were conducted to identify factors associated with MM or better status.…”