The metrial gland

Bulmer, D; Peel, S; Stewart, I. J.

doi:10.1016/0045-6039(87)90422-2

Cited by 39 publications

(27 citation statements)

References 30 publications

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“…The mouse uterus during pregnancy contains a large population of granulated metrial gland (GMG) 1 cells, which resemble LGL in several respects (5), including the presence of perforin-rich granules. GMG cells are derived from precursors in the bone marrow, and exhibit the markers of NK cells, eg., asialo GM1 and LGL-1 (6-8).…”

Section: Discussionmentioning

confidence: 99%

Perforin-expressing granulated metrial gland cells in murine deciduoma.

Zheng

Joag

Parr

et al. 1991

The Journal of Experimental Medicine

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SummaryIt has previously been shown that granulated metrial gland (GMG) cells of the pregnant uterus express abundant quantities of the lymphocyte pore-forming protein, perforin. No perforin was present before implantation of the embryo, but large numbers of perforin-producing GMG cells were observed after implantation, which coincides with decidualization of the uterus. The possible source of the activation factors responsible for perforin gene induction in GMG cells was studied here with the pseudopregnancy model, in which cervical stimulation of mice during estrus leads to a series of hormonal changes resembling those seen in pregnancy, but in the absence of an embryo. Subsequent stimulation of the uterus of pseudopregnant mice with oil causes the stimulated portion of the endometrium to differentiate into decidual tissue. Perforin-containing GMG cells were in fact present in the deciduomata, but not in adjacent nondecidualized tissues of the same mice. These results suggest that maternal factors associated with decidual tissue are responsible for the local expression of perforin in GMG cells.

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Section: Discussionmentioning

confidence: 99%

Perforin-expressing granulated metrial gland cells in murine deciduoma.

Zheng

Joag

Parr

et al. 1991

The Journal of Experimental Medicine

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“…During the critical period of initial placenta development, two leukocyte types predominate in the allogeneic pregnant mouse uterus, cells of the monocyte/ macrophage lineage and the specialized uterine NK (uNK) cells. uNK cells have received considerable attention because of their abundance, unusual size (up to 50 lm) [1] and only partly understood function at the maternal/fetal interface. Several observations suggest that these cells play an important role in reproduction, including regulation of trophoblast invasion and development, but a protective role against placental infections has also been proposed [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

“…uNK cells have received considerable attention because of their abundance, unusual size (up to 50 lm) [1] and only partly understood function at the maternal/fetal interface. Several observations suggest that these cells play an important role in reproduction, including regulation of trophoblast invasion and development, but a protective role against placental infections has also been proposed [1][2][3]. It was recently shown that uNK cells are a major source of IFN-c, which modifies the expression of genes in the uterine vasculature and stroma, initiating vessel instability and facilitating pregnancy-induced remodeling of decidual arteries [4,5].…”

Section: Introductionmentioning

confidence: 99%

Functional involvement of P‐selectin and MAdCAM‐1 in the recruitment of α4β7‐integrin‐expressing monocyte‐like cells to the pregnant mouse uterus

et al. 2004

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Leukocyte recruitment to the pregnant mouse uterus has been suggested to be associated with highly regulated expression of distinct patterns of vascular adhesion receptors. One of the most striking observations is the combined expression of mucosal addressin cell adhesion molecule-1 (MAdCAM-1) and P-selectin by maternal vessels of the vascular zone during the critical period of initial placenta development. The predominant cell population within these vessels is of the monocyte/macrophage lineage and expresses the mucosal integrin a4b7, which represents the ligand for MAdCAM-1; neutrophils and lymphocytes are rare. To directly assess the importance of identified adhesion receptors, we undertook longterm in vivo inhibition studies using monoclonal antibodies to inhibit the contribution of MAdCAM-1 in leukocyte trafficking to the decidua or to deplete a4b7 + leukocytes. In addition, implantation sites of mouse strains genetically deficient in specific adhesion receptors were investigated. Our results underline the importance of predicted adhesion pathways in the recruitment of monocyte-like cells, especially those expressing a4b7. Interestingly, maternal/ fetal units with inhibited recruitment of a4b7 + leukocytes or the absence of these cells are characterized by reduced size and frequency of uterine NK cells.

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“…3, a and b). Metrial gland cells are characterized by cytoplasmic granules which stain strongly with PAS even after diastase digestion (Bulmer et al, 1987). Fig.…”

Section: Analysis Of 2ar Expression By In Situ Hybridization: Expressmentioning

confidence: 99%

“…Fig. 2 shows that transcripts are confined to a distinct population of individual cells, corresponding in size and distribution to granulated metrial gland (GMG) cells of maternal bone marrow origin (Bell, 1983;Bulmer et al, 1987). From serial sections of the 6.5 d p.c.…”

Section: Analysis Of 2ar Expression By In Situ Hybridization: Expressmentioning

confidence: 99%

Developmental expression of 2ar (osteopontin) and SPARC (osteonectin) RNA as revealed by in situ hybridization

Nomura¹,

Wills²,

Edwards³

et al. 1988

The Journal of Cell Biology

492

244

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Abstract. 2ar has been identified as a gene inducible by tumor promoters and growth factors in a variety of cultured mouse cell lines (Smith, J. H., and D. T. Denhardt. 1987. J. Cell. Biochem. 34:13-22 262:2900-3907.). In this paper we use Northern blot analysis and in situ hybridization to localize expression of 2ar during mouse embryogenesis. 2ar RNA is first detected in developing limb bones and calvaria at 14.5 d p.c., in a population of cells distinct from those expressing SPARC (osteonectin). High levels of 2ar expression are also seen in the bone marrow-derived granulated metrial gland cells of the deciduum and placenta, and in a number of epithelial tissues, including embryonic and postnatal kidney tubules, uterine epithelium and sensory epithelium of the embryonic ear. The temporal and spatial pattern of 2ar expression seen in vivo suggests that the protein plays a wider role than previously realized, in processes which are not confined to bone development.

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The metrial gland

Cited by 39 publications

References 30 publications

Perforin-expressing granulated metrial gland cells in murine deciduoma.

Perforin-expressing granulated metrial gland cells in murine deciduoma.

Functional involvement of P‐selectin and MAdCAM‐1 in the recruitment of α4β7‐integrin‐expressing monocyte‐like cells to the pregnant mouse uterus

Developmental expression of 2ar (osteopontin) and SPARC (osteonectin) RNA as revealed by in situ hybridization

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