The Metastatic Spread of Breast Cancer Accelerates during Sleep: How the Study Design can Affect the Results

Houshyari, Mohammad; Taghizadeh‐Hesary, Farzad

doi:10.31557/apjcp.2023.24.2.353

Cited by 3 publications

(2 citation statements)

References 22 publications

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“…Hormone replacement therapy, depending on type, duration, and timing, may elevate risk. Conversely, reproductive history, modifiable through family planning, influences risk; early menstruation, late menopause, and nulliparity or late childbirth increase susceptibility (Houshyari and Taghizadeh-Hesary, 2023;Svyatova et al, 2019). Breastfeeding, partly modifiable, contributes positively to risk reduction.…”

Section: Discussionmentioning

confidence: 99%

Association of Gene Polymorphisms with Breast Cancer Risk in the Kazakh Population

Shanazarov,

Zhapparov,

Kumisbekova

et al. 2023

Asian Pac J Cancer Prev

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Objective: The research aim is analyzing and identify reliable genetic markers of breast cancer risk in the Kazakh population. Methods: The databases were analyzed with the selection of polymorphisms associated with the development of breast cancer and further genotypic study of a group of women with a confirmed diagnosis of breast adenocarcinoma (group No. 1) and a group of relatively healthy women (group No. 2). Result: The research presents the results of a study on the frequency of certain single-nucleotide polymorphisms in patients with breast cancer in the Republic of Kazakhstan. The frequency of single-nucleotide polymorphisms rs4646, rs1065852, rs4244285, rs67376798, rs6504950, rs2229774, rs1800056, rs16942, rs4987047 is statistically significant compared to the control group of patients. These polymorphisms in the Kazakh population have a direct association with an increased risk of breast cancer in women and may be used as cancer indicators during the genetic screening of patients with a complicated family history. Single-nucleotide polymorphisms such as rs55886062, rs3918290, rs12721655, rs4987117, rs2229774, rs11203289, rs137852576, rs11571833, rs80359062 and rs11571746 were found in more than 40. Zero percent of patients with breast cancer may be used as markers for detecting patients at increased risk of breast malignancy in the Kazakh population without a history of poor family history. Conclusion: The usage of the data obtained in a set of state programs for early screening of patients will improve the rates of early breast tumor detection, form groups of patients with a high risk of disease development and improve the quality and expectancy of life.

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Section: Discussionmentioning

confidence: 99%

Association of Gene Polymorphisms with Breast Cancer Risk in the Kazakh Population

Shanazarov,

Zhapparov,

Kumisbekova

et al. 2023

Asian Pac J Cancer Prev

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“…TAMs are highly plastic cells involved in various actions, including suppressing the immune system, promoting tumor angiogenesis, and increasing resistance of tumor cells to chemotherapy [100]. Poor prognosis in many types of cancer is directly related to the number of TAMs in the TME [59,103]. Studies have shown that in certain types of cancer, including lung, skin, head and neck, bladder, and ovarian cancer, miRNAs secreted by cancer cells can increase the recruitment of macrophages to the TME [102,[104][105][106][107][108].…”

Section: Exosomal Mirnas and Tumor-associated Macrophagesmentioning

confidence: 99%

Molecular Mechanisms for Targeting Metastatic Cancer Cells and to Overcome or Prevent Chemotherapy Resistance

Eslami,

Davarpanah,

Rismanbaf

et al. 2023

Preprint

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Cancer is a devastating disease, causing tremendous morbidity and mortality each year. Cancer can be considered as a genetic disease in the sense that instabilities in protooncogenes and tumor suppressor genes are among the hallmarks of cancer progression and metastasis. However, a particular cancer can express different proteins in different patients, making cancer a heterogeneous disease. This heterogeneity in part influences treatment resistance and failure. Therefore, it is crucial to understand the mechanism by which cancer cells develop and enhance resistance to different agents. This review aims to present the general paradigm and recent updates on cancer cell resistance to different antitumor agents. It demonstrates that tumor resistance results from a myriad of factors, including tumor microenvironment, supporting immune cells, and cancer stem cells. This interaction contributes to cancer cells overcoming the therapeutic effects of different classes of antitumor agents, such as cytotoxic chemotherapeutics, targeted agents, and immunotherapies. With the development of advanced molecular analysis, specialized genomic assessment has assisted clinicians and researchers in choosing selected agents combating cancer cells. Together, this approach can potentially reduce treatment toxicity, health system burden, and financial costs while improving patient quality of life. Understanding the exact mechanism of drug resistance in cancer cells can open the way to new effective and less toxic therapeutics.

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A critical review on exploring tumor Microenvironment's impacts on radioresistance

Houshyari

2024

Journal of Radiation Research and Applied Sciences

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The Metastatic Spread of Breast Cancer Accelerates during Sleep: How the Study Design can Affect the Results

Cited by 3 publications

References 22 publications

Association of Gene Polymorphisms with Breast Cancer Risk in the Kazakh Population

Association of Gene Polymorphisms with Breast Cancer Risk in the Kazakh Population

Molecular Mechanisms for Targeting Metastatic Cancer Cells and to Overcome or Prevent Chemotherapy Resistance

A critical review on exploring tumor Microenvironment's impacts on radioresistance

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