The metabotropic glutamate receptor 2/3 antagonist LY341495 improves working memory in adult mice following juvenile social isolation

Zhang, Xiaoqin; Jiang, Hejia; Xu, Le; Yang, Siyu; Wang, Gao-Zhe; Jiang, Hongde; Wu, Teng; Du, Han; Yu, Zhipeng; Zhao, Qiqi; Ling, Yu; Zhang, Zhongyu; Shen, Haowei

doi:10.1016/j.neuropharm.2020.108231

Cited by 9 publications

(3 citation statements)

References 44 publications

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“…[121][122][123] Conversely, mGluR2/3 agonist, LY379268, has also improved recognition memory impairment in SI rats. 121,124 Earlier investigations have suggested and decreased BDNF induced by chronic isolation were modified in EE. 123 Social activity among rats exposed to a novel environment was higher than standard rats.…”

Section: Drug Tre Atmentsmentioning

confidence: 97%

“…Further, a single treatment with LY341495 improved isolated mice performance in the Y maze test but not in the novel object recognition test, while repeating the treatments were efficient for both tasks 121‐123 . Conversely, mGluR2/3 agonist, LY379268 , has also improved recognition memory impairment in SI rats 121,124 . Earlier investigations have suggested that stress and anxiety‐like behaviours have appeared because of a mediator called the Corticotropin‐releasing factor (CRF).…”

Section: Drug Treatmentsmentioning

confidence: 99%

“…Additionally, Results have revealed that in socially isolated mice, the excitatory presynaptic release of pyramidal neurons in the mPFC has attenuated, and metabotropic glutamate receptor 2/3 (mGluR2/3) antagonist, LY341495 , played a crucial role in recovering working memory by building reasonably vast synaptic strength in the mPFC in SI‐reared mice 121 . Further, a single treatment with LY341495 improved isolated mice performance in the Y maze test but not in the novel object recognition test, while repeating the treatments were efficient for both tasks 121‐123 . Conversely, mGluR2/3 agonist, LY379268 , has also improved recognition memory impairment in SI rats 121,124 .…”

Section: Drug Treatmentsmentioning

confidence: 99%

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Depresssion, anxiety and other cognitive consequences of social isolation: Drug and non‐drug treatments

Zadeh

Rahmani

Alidadi

et al. 2021

Int J Clinical Practice

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Social interaction has a crucial role in human well-being, both mentally and physically. 1 Human social isolation (SI) happens when the social relationship between individuals become deficient. 2 Moreover, it mostly occurs when the number of individuals, who are members of social links, decrease, or the qualification of social relations, diminishes. During SI, people experience unpleasant situations mentally, emotionally, and spiritually. 3,4 Some conditions force individuals to leave human groups and reduce their socia9l interactions, presence in the population, and group activities. Being single, getting a divorce and separation may also result in isolation. 2,5 Further, weak connections and lack of social support have shown to be significant risk factors of isolation, which result in loneliness, stress, and committing suicide. 6,7 Meanwhile, some infectious diseases such as COVID-19, AIDS and some physical disorders have shown to develop SI in humans. 8,9 Also, some studies have confirmed impairment in sensory processing is significantly correlated with depression.Extreme sensory processing patterns make humans feel hopeless and depressed. 10,11 As previous scientific research has described the association between vision disabilities and hearing problems with isolation and reduced human relation. 12 Loneliness is considered as a risk factor for many psychiatric disorders such as adjustment disorder, chronic stress, insomnia and also late-life dementia 9 which may be long lasting. 13 Adverse effects on cognition and behaviour, decision-making, and pain perception are followed by social isolation. 14,15 SI has shown to change the immune system, glutamate system, and hormones. [15][16][17] Besides, cardiovascular disease, high blood pressure, stroke, and developmental neurodegenerative diseases have occurred during SI. 15 It has been

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Section: Drug Tre Atmentsmentioning

confidence: 97%

Section: Drug Treatmentsmentioning

confidence: 99%

Section: Drug Treatmentsmentioning

confidence: 99%

See 1 more Smart Citation

Depresssion, anxiety and other cognitive consequences of social isolation: Drug and non‐drug treatments

Zadeh

Rahmani

Alidadi

et al. 2021

Int J Clinical Practice

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miR-124 regulates early isolation-induced social abnormalities via inhibiting myelinogenesis in the medial prefrontal cortex

Pang

Feng

Jin

et al. 2022

Cell. Mol. Life Sci.

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Environmental Enrichment Improves the Recognition Memory in Adult Mice Following Social Isolation via Downregulation of Kv4.2 Potassium Channels

Shang,

Dong,

et al. 2023

Mol Neurobiol

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The recognition memory is a cognitive process that enables us to distinguish familiar objects and situations from new items, which is essential for mammalian survival and adaptation to a changing environment. Social isolation (SI) has been implicated as a detrimental factor for recognition memory. The medial prefrontal cortex (mPFC) has been shown to carry information concerning the relative familiarity of individual stimuli, and modulating neuronal function in this region may contribute to recognition memory. The present study aimed to investigate the neuronal mechanisms in the mPFC of environmental enrichment (EE) on recognition memory in adult mice following SI. Mice were assigned into three groups: Control, SI, and SI + EE group. Novel location recognition (NLR) and Novel object recognition (NOR) tests were performed to evaluate the recognition memory. The levels of Kv4 channels were assessed by qRT-PCR and Western blotting. The effects of SI and SI + EE on the intrinsic excitability of pyramidal neurons in the mPFC were measured using whole-cell recording. We found that SI led to a reduction in the intrinsic excitability of pyramidal neurons. Speci cally, we have identi ed that the reduction in the ring activity of pyramidal neurons resulted from alterations in the function and expression of Kv4.2 channels. Furthermore, EE regulated Kv4.2 channels, normalized the activity of pyramidal neurons and restored the behavioral de cits following SI. Thus, the roles of Kv4.2 channels in intrinsic excitability of pyramidal neurons suggest that the Kv4.2 channels present a promising therapeutic target for recognition memory impairment.

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The metabotropic glutamate receptor 2/3 antagonist LY341495 improves working memory in adult mice following juvenile social isolation

Cited by 9 publications

References 44 publications

Depresssion, anxiety and other cognitive consequences of social isolation: Drug and non‐drug treatments

Depresssion, anxiety and other cognitive consequences of social isolation: Drug and non‐drug treatments

miR-124 regulates early isolation-induced social abnormalities via inhibiting myelinogenesis in the medial prefrontal cortex

Environmental Enrichment Improves the Recognition Memory in Adult Mice Following Social Isolation via Downregulation of Kv4.2 Potassium Channels

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