The metabolite dimethylsulfoxonium propionate extends the marine organosulfur cycle

Thume, Kathleen; Gebser, Björn; Chen, Liang; Meyer, Nils; Kieber, David J.; Pohnert, Georg

doi:10.1038/s41586-018-0675-0

Cited by 108 publications

(159 citation statements)

References 38 publications

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“…An intensively studied example of a metabolite that structures the marine environment is the omnipresent sulfur containing dimethylsulfoniopropionate (DMSP). This compound is produced by most phytoplankton species, but also certain bacteria contribute to the DMSP pool (Thume et al, 2018). DMSP and its degradation products carry essential physiological functions as osmoregulators and antioxidants in the producing algae (Johnston et al, 2016).…”

Section: Cross-kingdom Exchange Of Resourcesmentioning

confidence: 99%

“…Recently the concept of DMSP as an essential metabolite in sulfur cycling has been expanded by the description of the structurally related oxidised dimethylsulfoxonium propionate (DMSOP). This metabolite, that is formed by algae and bacteria can serve as precursor for oceanic dimethylsulfoxide (DMSO) and is expanding the oceanic sulfur cycle that is driven by the connected metabolism of algae and bacteria (Thume et al, 2018). With the ongoing discovery of other widely distributed organic osmolytes containing reduced sulfur, including gonyol, dimethylsulfonioacetate and 2,3-dihydroxypropane-1-sulfonate (DHPS), the field of algalÀbacterial sulfur shuttling is now expanding (Gebser & Pohnert, 2013;Durham et al, 2015).…”

Section: Cross-kingdom Exchange Of Resourcesmentioning

confidence: 99%

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Algae−bacteria interactions that balance the planktonic microbiome

2019

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Summary Phytoplankton communities within the photic zones of the oceans and lakes are characterised by highly complex assemblages of unicellular microalgae and associated bacteria. The interconnected evolutionary history of algae and bacteria allowed the formation of a wide spectrum of associations defined by orchestrated nutrient exchange, mutual support with growth factors, quorum sensing mediation, and episodic killing of the partners to obtain more resources. In this review, we discuss how these cross‐kingdom interactions shape plankton communities that undergo annual, seasonal switching between alternative states with balanced multispecies consortia. We illustrate how these microscopic interactions can have consequences that scale up to influence global element cycling.

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Section: Cross-kingdom Exchange Of Resourcesmentioning

confidence: 99%

Section: Cross-kingdom Exchange Of Resourcesmentioning

confidence: 99%

Algae−bacteria interactions that balance the planktonic microbiome

2019

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“…DMS oxidation products aggregate to aerosols that can affect cloud formation with significant impact on the local and global climate . The recent discovery that the oxidation product of DMSP—dimethylsulfoxonium propionate (DMSOP)—is also an abundant marine product added another potentially important link in the marine organosulfur cycle …”

Section: Figurementioning

confidence: 99%

In Vitro Reconstitution of Bacterial DMSP Biosynthesis

Liao

Seebeck

2019

Angewandte Chemie

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Dimethylsulfoniopropionate (DMSP) is one of the most abundant sulfur metabolites in marine environments. The biosynthesis of DMSP and its degradation to dimethylsulfide are important links in the planetary sulfur cycle. Herein, the first complete description of a DMSP biosynthetic pathway is provided by the in vitro reconstitution of four enzymes from Streptomyces mobaraensis. The isolation of DMSP from S. mobaraensis cells grown at high salinity confirmed that this actinobacterium is indeed is a DMSP‐producing organism. The described DMSP biosynthesis follows the same route as that previously described for angiosperm plants. Despite this chemical congruence, limited sequence similarity between plant and bacterial enzymes suggests that the two biosynthetic activities emerged by convergent evolution.

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“…[3] DMS oxidation products aggregate to aerosols that can affect cloud formation with significant impact on the local and global climate. [5] As ac ellular metabolite,D MSP has been implicated as aprotectant against osmotic,oxidative,orthermal stress, [6] as signaling molecule, [7] or simply as as ulfur source for marine microorganisms. [5] As ac ellular metabolite,D MSP has been implicated as aprotectant against osmotic,oxidative,orthermal stress, [6] as signaling molecule, [7] or simply as as ulfur source for marine microorganisms.…”

mentioning

confidence: 99%

“…[4] The recent discovery that the oxidation product of DMSPdimethylsulfoxonium propionate (DMSOP)-is also an abundant marine product added another potentially important link in the marine organosulfur cycle. [5] As ac ellular metabolite,D MSP has been implicated as aprotectant against osmotic,oxidative,orthermal stress, [6] as signaling molecule, [7] or simply as as ulfur source for marine microorganisms. [8] One difficulty in studying the physiological function of DMSP is that the genetic basis for DMSP biosynthesis is poorly understood.…”

mentioning

confidence: 99%

In Vitro Reconstitution of Bacterial DMSP Biosynthesis

Liao

Seebeck

2019

Angew Chem Int Ed

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Dimethylsulfoniopropionate (DMSP) is one of the most abundant sulfur metabolites in marine environments.The biosynthesis of DMSP and its degradation to dimethylsulfide are important links in the planetary sulfur cycle.H erein, the first complete description of aD MSP biosynthetic pathway is provided by the in vitro reconstitution of four enzymes from Streptomyces mobaraensis.T he isolation of DMSP from S. mobaraensis cells grown at high salinity confirmed that this actinobacterium is indeed is aDMSP-producing organism. The described DMSP biosynthesis follows the same route as that previously described for angiosperm plants.D espite this chemical congruence,l imited sequence similarity between plant and bacterial enzymes suggests that the two biosynthetic activities emerged by convergent evolution.

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The metabolite dimethylsulfoxonium propionate extends the marine organosulfur cycle

Cited by 108 publications

References 38 publications

Algae−bacteria interactions that balance the planktonic microbiome

Algae−bacteria interactions that balance the planktonic microbiome

In Vitro Reconstitution of Bacterial DMSP Biosynthesis

In Vitro Reconstitution of Bacterial DMSP Biosynthesis

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