The Metabolism of the Estrogens Part One

The Influence of Thyroid Function on the Allen-Doisy Dose Response Line Obtained by the Administration of Oestrone and Oestradiol-3,17ß in Mice

“…However, there is good reason to suppose that oestrone is in some way modified in various tissues of the body, and this idea is further supported by the recent observations of Claringbold (unpublished data) that cyanide significantly increases the intravaginal activity of oestrone but has no effect on the intravaginal activity of oestradiol-3,17 {3. The various metabolic interconversions of oestrogens have been discussed by Heard (1949). The known interconversions of oestrone, oestradiol-3,17 {3, and oestriol can be indicated as follows, whence it is seen that oestriol has not so far been shown to change to either of the others: Bischoff, Katherman, and Yee (1951) have some evidence that in bloQd at least some of the oestrone is converted to oestradiol-3,17{3.…”

Studies on Estrogen Metabolism in Rabbit in Vivo

“…Small amounts of estrone and 17-epiestriol were noted in urine of the estrogentreated rabbit. 4. Estriol was found to be partially converted to 17-epiestriol.…”

The Chemistry and Metabolism of the Steroid Hormones

“…Estrogen metabolism.-Experimental investigations of estrogen metab olism have been reviewed by Heard (20) and Heard & Saffran (21). Segaloff (22) has considered estrogen metabolism particularly in relation to clinical problems.…”