The Metabolism of Terbutaline<i>In Vitro</i>by Rat and Human Liver<i>O</i>-Methyltransferases and Monoamine Oxidases

Persson, Kaj; Persson, Karin

doi:10.3109/00498257209111064

Cited by 35 publications

(2 citation statements)

References 8 publications

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“…In the case of TMI derivatives, however, the transformation from catechol type (AQ-1 10) to resorcinol type (II) did not cause any significant decrease in bronchodilating activity. On the other hand, it has been shown that the duration of the effect of resorcinol derivatives was longer than that of catechol derivatives (14,15) and that the former compounds were less sensitive to catechol-O-methyltransferase (COMT) than the latter (18) . The bronchodilating action of .1 (monohydroxy analogue) and II (resorcinol type) was also longer-lasting, suggesting that these compounds are little metabolized by COMT.…”

Section: Methodsmentioning

confidence: 99%

Mechanism of Chronotropic and Inotropic Effects of Phenylephrine

Chiba¹

1977

Japanese Journal of Pharmacology

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Section: Methodsmentioning

confidence: 99%

Mechanism of Chronotropic and Inotropic Effects of Phenylephrine

Chiba¹

1977

Japanese Journal of Pharmacology

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“…salbutamol, hexoprenaline and ritodrine or resorcinol derivatives such as fenoterol. They are resistant towards the actions of monoamine oxidase (MAO) and catechol-omethyl transferase (COMT) (Persson & Persson, 1972). The exception is hexoprenaline which has been shown to undergo o-methylation in rat (Kamper et al, 1972).…”

Section: Introductionmentioning

confidence: 99%

Sulphate conjugation of beta 2‐adrenoceptor stimulating drugs by platelet and placental phenol sulphotransferase.

Schneider¹

1984

Brit J Clinical Pharma

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A possible route of metabolism of 38-adrenoceptor stimulating drugs used in obstetrics consists of conjugation by the enzyme phenol sulphotransferase. The substrate specificities of the platelet and the placental enzymes towards these drugs were tested. The specific activities of the ,3-adrenoceptor agonists were found to be relatively similar to those obtained with the catecholamine dopamine but their Km values were considerably higher.

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Pharmacokinetics of non‐prescription sympathomimetic agents

Chua

Benrimoj

Triggs

1989

Biopharm & Drug Disp

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The pharmacokinetics of non-prescription sympathomimetic agents are discussed with respect to absorption from the gastrointestinal tract, volumes of distribution, metabolism and renal excretion. Where specific data are not available, postulations are made with inference from the chemical structures of these agents, or from studies with other drugs. No studies on hypertensive patients have been found, but attempts are made to correlate any possible changes in the pharmacokinetics of these sympathomimetic agents to hypertensive patients as a high proportion of the elderly population is hypertensive. Sympathomimetic agents with lesser polar hydroxl groups, for example, are thought to be more lipophilic and are more readily absorbed from the gastrointestinal tract, have higher volumes of distribution, and are more extensively metabolized. Major metabolic pathways include oxidation, deamination, demethylation, and conjugation. Most of these agents are excreted primarily through the kidneys and due to their basic nature, the rate of excretion is dependent on urinary pHs. Any alteration in kidney functions such as in the aged is, therefore, expected to have some clinical significance on the pharmacokinetics of these agents.

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The Metabolism of TerbutalineIn Vitroby Rat and Human LiverO-Methyltransferases and Monoamine Oxidases

Cited by 35 publications

References 8 publications

Mechanism of Chronotropic and Inotropic Effects of Phenylephrine

Mechanism of Chronotropic and Inotropic Effects of Phenylephrine

Sulphate conjugation of beta 2‐adrenoceptor stimulating drugs by platelet and placental phenol sulphotransferase.

Pharmacokinetics of non‐prescription sympathomimetic agents

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