The metabolism of normal and tumour tissue

Dickens, F.; Greville, G. D.

doi:10.1042/bj0291468

Cited by 187 publications

(62 citation statements)

References 8 publications

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“…It has been reported, for example, in inflammatory exudates (10), in a tuberculous lymph node (21), in local vaccinia lesions in rabbit skin (14), and in various tissues damaged by mechanical means (13). It is also a characteristic feature of certain malignant tumors (15).…”

Section: Discussionmentioning

confidence: 99%

Studies on the Mechanism of the Shwartzman Phenomenon

Thomas

Stetson

1949

Journal of Experimental Medicine

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Rabbit skin which is prepared for the Shwartzman phenomenon by an intradermal injection of meningococcal toxin exhibits, in vitro, a high degree of aerobic glycolysis. This metabolic abnormality is reflected, in vivo, by a measurable increase in the concentration of lactic acid in the prepared skin. Some increase in anaerobic glycolysis also occurs in prepared skin; this is of less degree than the increase in aerobic glycolysis. The respiratory quotient of prepared skin tends to be somewhat higher than that of normal skin, although the oxygen uptake is not significantly altered. Gross hemorrhagic lesions which resemble the Shwartzman phenomenon are produced by the intradermal injection of papain into rabbits which have received an intravenous injection of meningococcal toxin 1 hour previously. Such hemorrhagic reactions are not observed when papain is injected into normal rabbit skin. Similarly, hemorrhagic lesions are produced by the intradermal injection of cysteine and BAL, following an intravenous injection of meningococcal toxin. An hypothesis to explain the Shwartzman phenomenon, which implicates tissue protease in the damage to the blood vessels of the skin, is proposed.

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Section: Discussionmentioning

confidence: 99%

Studies on the Mechanism of the Shwartzman Phenomenon

Thomas

Stetson

1949

Journal of Experimental Medicine

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“…For the uptake of K (41), or for the membrane depolarization due to potassium (52), or for the production of potassium stimulation, or to maintain the rate of oxygen uptake of cerebral cortical slices, or for the maintenance of resting membrane potential, a minimum concentration of sodium in the medium was necessary. And this sodium seems unable to be replaced by any other ion (14,26,53). In the present experiment, when the ex ternal K' ion concentration was changed to 7 mm, 21 mm or 50 mm, there was almost no change in the respiration and metabolism of the tissue in the absence of external sodium, either in the presence or in the absence of electrical stimulation, as compared with those of the tissue in NaCl-free medium ; that is, potassium alone seemed metabolically indifferent, when the external sodium was absent.…”

Section: Besides Itmentioning

confidence: 99%

The Effects of Sodium, Potassium and Calcium on Metabolism of Rat’s Cerebral Cortical Slice With or Without Electrical Stimulation

Kozawa

Naito

1966

Japanese Journal of Pharmacology

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“…It might be argued that these ionic effects on metabolism thus depend on the final solution being hypertonic. This point was raised by Dickens & Greville (1935) Normal Ringer: stock solution A (conc. Ringer solution) 2 ml.…”

Section: Resultsmentioning

confidence: 99%

“…Potassium ions cause pronounced effects on the metabolism of glucose by slices of cerebral cortex, increasing aerobic glycolysis and respiration and inhibiting anaerobic glycolysis (Ashford & Dixon, 1935;Dickens & Greville, 1935). Gerard (1938) suggested that potassium may leak out of neurones during asphyxia and stated that he had some evidence in support of this contention (see also Cowan, 1934).…”

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confidence: 92%