The Metabolism of D-Ribose in Man

Segal, Stanton; Foley, Joseph B.

doi:10.1172/jci103658

Cited by 69 publications

(47 citation statements)

References 54 publications

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“…Segal and Foley [21,22] found different levels of hypoglycemia with D-ribose supplementation depending upon dose with higher doses producing a greater decrease. Gross et al [23] has published similar findings.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Hematological and Biochemical parameters with extended D-Ribose ingestion

Seifert

Frelich

Shecterle³

et al. 2008

Journal of the International Society of Sports Nutrition

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D-ribose, a naturally occurring pentose carbohydrate, has been shown to replenish high-energy phosphates following myocardial ischemia and high intensity, repetitive exercise. Human studies have mainly involved short-term assessment, including potential toxicity. Reports describing adverse effects of D-ribose with prolonged ingestion have been lacking. Therefore, this study assessed the toxicity of extended consumption of D-ribose in healthy adults. Nineteen subjects ingested 20 grams/Day (10 grams, twice a Day) of ribose with serial measurements of biochemical and hematological parameters at Days 0, 7, and 14. No significant toxic changes over the 14-day assessment period occurred in complete blood count, albumin, alkaline phosphatase, gamma glutamyltransferase, alanine amiotransferase, and aspartate aminotransferase. However, D-ribose did produce an asymptomatic, mild hypoglycemia of short duration. Uric acid levels increased at Day 7, but decreased to baseline values by Day 14. D-ribose consumption for 14 days appears not to produce significant toxic changes in both hematological and biochemical parameters in healthy human volunteers.

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Section: Discussionmentioning

confidence: 99%

Assessment of Hematological and Biochemical parameters with extended D-Ribose ingestion

Seifert

Frelich

Shecterle³

et al. 2008

Journal of the International Society of Sports Nutrition

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“…Methods for the collection and C' counting of expired CO,, for preparation and radioactive assay of blood samples, and C' counting and chromatography of labeled compounds in urine have previously been described (12).…”

Section: Methodsmentioning

confidence: 99%

“…It is also apparent that D-ribose C14 differs from the other pentoses in the extent of oxidation of carbon one to CO2 and the seemingly different mechanism is reflected in the shape of the ribose curve. Interpretation of the latter has received comment previously (12). The more extensive metabolism of ribose C14 as compared to the other pentoses may be related to its extensive conversion to D-glucOse.…”

Section: Expired C1402 After Administration Of C'4pentosementioning

confidence: 99%

“…Previous reports have described the physiological disposition of large quantities of infused pentoses (10), the effect of insulin on blood levels of infused pentoses (11) as well as studies of the metabolism of D-ribose (12). This paper reports some observations on the fate of C14 labeled D-xylOse, D-lyxose, D-arabinose and L-arabinose administered in trace quantities intravenously to normal human subjects.…”

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confidence: 97%

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The Metabolic Fate of C14 Labeled Pentoses in Man

Segal¹,

Foley²

1959

J. Clin. Invest.

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The role of pentoses in intermediary metabolism has received much attention within the past few years. The phosphate esters of D-ribose, D-ribulose and D-xylulose have been identified as key intermediates in the pentose phosphate pathway of glucose metabolism in both plant and mammalian tissue (1). More recently, another alternate pathway of glucose dissimilation, the uronic acid pathway, has been described in which L-Xylulose, xylitol and D-xylulose are intermediates (2).Several pentoses have been identified in normal urine: the aldopentoses xylose, arabinose and ribose (3, 4) and the ketopentoses D-ribulose and L-xylulose (5). Large quantities of the latter sugar are excreted in the disease essential pentosuria (6, 7), which appears to be due to a defect in the further conversion of L-xylulOse to the sugar alcohol xylitol (8). In addition to L-xylulOse Touster and Harwell (9) have also reported the isolation of L-arabitol from the urine of pentosuric subjects.Because of increasing awareness of the biological importance of the pentoses, certain aspects of pentose metabolism in man have been investigated in this laboratory. Previous reports have described the physiological disposition of large quantities of infused pentoses (10), the effect of insulin on blood levels of infused pentoses (11) as well as studies of the metabolism of D-ribose (12). This paper reports some observations on the fate of C14 labeled D-xylOse, D-lyxose, D-arabinose and L-arabinose administered in trace quantities intravenously to normal human subjects. Some of the previously published data (12) on C14 ribose metabolism are included for purposes of comparison. METHODSFive experiments were performed in four normal male volunteers aged 18 to 21. Each subject had been on a 250 Gm. carbohydrate diet for at least three days and was fasted overnight prior to study.Five /Ac. of each sugar dissolved in 250 ml. of normal saline were infused over a 15 minute period. Expired air samples were collected for 4 minutes at 15 to 60 minute intervals for 6 hours. Urine samples were collected at hourly intervals for 6 hours and pooled thereafter till 24 hours had elapsed from the start of the experiment. A urine sample was obtained at the twentyfifth hour to determine if C" was still being excreted. Urine was preserved by freezing at -20' C. Blood wvas collected at 20 minute intervals.Methods for the collection and C' counting of expired CO,, for preparation and radioactive assay of blood samples, and C' counting and chromatography of labeled compounds in urine have previously been described (12).The C" pentoses D-xylose, D-lyxose, D-arabinose, Larabinose and D-ribose (Figure 1) with specific activity of 0.67, 1.65, 1.65, 1.11, 2.6 and 2.01 ,lc. per mg., respec-H C=O H-C-OH

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“…Schneider et al reported that D-ribose improved hemodynamic parameters and prevented the activation of pro-apoptotic c-fos during ventricular tachycardia with 450 mg/kg of D-ribose in rats (Schneider et al 2008). Meanwhile, in previous report regarding the metabolism of D-ribose in man, a marked reduction in blood glucose concentration occurred after 20 and 10 gram of D-ribose infusion, presumably by inhibiting the enzyme phosphoglucomutase (Segal and Foley 1958). Further research is required to clarify the difference of glucose concentration between rat and man.…”

Section: Discussionmentioning

confidence: 97%