The metabolism of cis-dichlorodiammineplatinum (II): Distribution, clearance, and toxicity

Lagasse, Leo D.; Pretorius, R G; Petrilli, Edmund S.; Ford, K.L.; Hoeschele, James D.; Kean, Charles

doi:10.1016/0002-9378(81)90545-7

Cited by 25 publications

(4 citation statements)

References 3 publications

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“…Nephrotoxicity was dose-related, and a single administration of 4 mg/kg was more nephrotoxic than were two daily consecutive administrations of 2 mg/kg. Lagasse et al (1981) reported that the changes in serum Cr and BUN were similar between i.p. and i.v.…”

Section: Discussionmentioning

confidence: 87%

Studies on nephrotoxicity following a single and repeated administration of cis-diamminedichloroplatinum (CDDP) in rats.

Mizushima

Nagahama

Yokoyama

et al. 1987

Tohoku J. Exp. Med.

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Section: Discussionmentioning

confidence: 87%

Studies on nephrotoxicity following a single and repeated administration of cis-diamminedichloroplatinum (CDDP) in rats.

Mizushima

Nagahama

Yokoyama

et al. 1987

Tohoku J. Exp. Med.

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“…7), but had no effect on 48 h Fos expression after cisplatin treatment. It is not clear where palonosetron might act to produce this effect because 5-HT 3 receptors are present in the NTS, in the AP, and on vagal afferents (peripherally and centrally) (36,54). 5-HT 3 receptor antagonism produces a greater reduction in cisplatin-induced emesis compared with vagotomy (4,62).…”

Section: Discussionmentioning

confidence: 97%

Chemotherapy agent cisplatin induces 48-h Fos expression in the brain of a vomiting species, the house musk shrew (Suncus murinus)

Jonghe¹,

Horn²

2009

American Journal of Physiology-Regulatory, Integrative and Comp

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Cancer chemotherapy drugs, such as cisplatin, potently produce nausea and vomiting. Acute effects of these treatments are partly controlled by antiemetic drugs, but the delayed effects (>24 h), especially nausea, are more difficult to treat. It is unknown what brain pathways produce this delayed sickness. Our prior data show that brain Fos expression is increased for at least 48 h after cisplatin treatment in the rat, a nonvomiting species. Here, we extend these observations by using house musk shrews (Suncus murinus), a species with an emetic response. Compared with saline injection, cisplatin treatment (30 mg/kg ip) induced Fos expression in hindbrain areas known to play a role in the generation of emesis, the dorsal motor nucleus (DMN), the area postrema, and the nucleus of the solitary tract (NTS), for up to 48 h. Cisplatin also stimulated Fos expression in the parabrachial nucleus (PBN) of the midbrain and the central nucleus of the amygdala (CeA) for at least 48 h after treatment. When animals were pretreated with the antiemetic palonosetron, a long-term serotonin type 3 (5-HT(3)) receptor antagonist, cisplatin-induced Fos expression was significantly attenuated in the NTS, DMN, and CeA at 6 h but not at 48 h. These results indicate that cisplatin activates a neural system that includes the dorsal vagal complex and forebrain in the musk shrew, which is partially suppressed by a 5-HT(3) receptor antagonist. Our findings suggest the existence of an extensive neural system that could be targeted to reduce nausea, vomiting, and malaise in cancer patients receiving chemotherapy.

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“…antitumour activity and has become the mainstay in the treatment of cervix, bladder, head and neck and small cell lung cancers (17). However, the drug shows a high level of nephrotoxicity (6,15,20) and drug resistance can develop in some cancers, independent of cancer type and stage (1,5).…”

Section: Tabmentioning

confidence: 99%

Biodistribution and dosimetry of 195mPt-cisplatin in normal volunteers

Sathekge

Wagener²,

Smith³

et al. 2013

Nuklearmedizin

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The metabolism of cis-dichlorodiammineplatinum (II): Distribution, clearance, and toxicity

Cited by 25 publications

References 3 publications

Studies on nephrotoxicity following a single and repeated administration of cis-diamminedichloroplatinum (CDDP) in rats.

Studies on nephrotoxicity following a single and repeated administration of cis-diamminedichloroplatinum (CDDP) in rats.

Chemotherapy agent cisplatin induces 48-h Fos expression in the brain of a vomiting species, the house musk shrew (Suncus murinus)

Biodistribution and dosimetry of 195mPt-cisplatin in normal volunteers

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