The metabolism of benzene in vitro

Snyder, Robert; Uzuki, Fumiko; Gonasun, Leonard; Bromfeld, Esther; Wells, A. L.

doi:10.1016/0041-008x(67)90078-6

Cited by 66 publications

(7 citation statements)

References 16 publications

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“…Many investigators have reported that benzene hydroxylase activity was increased by treatment of the animals with phenobarbital (10,19,59,62), but others, including us, reported a negative effect (18,50). This apparent discrepancy may be due to the difference in the substrate concentrations used in the metabolism stud y.…”

Section: Phenobarbital As a Clue To The Underlying Mechanism Of The Dmentioning

confidence: 73%

Pharmacokinetics of organic solvent vapors in relation to their toxicity.

Sato¹,

Nakajima²

1987

Scand J Work Environ Health

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SATO A, NAKAJIMA T. Pharmacokinetics of organic solvent vapors in relation to their toxicit y. Scand J Work Environ Health 13 (1987) 81-93 . The volatility and Iipophilicity by which organi c solvents are distinct from other chemicals constitut e a characteristic pharmacokinetic feature . They enter a living body by inhalation, preferentially distribute in the adipose tissue, and are eliminated by both expirat ion and metabolic degradation. Th is review article is centered on experiment al studies conducted by the authors and their co-workers, and it deals with (i) pharmacokinetic principl es, (ii) partition coefficients in relation to toxicity, (iii) significance of metabolism in the developmen t of organic solvent toxicity, and (iv) environmental factors that alt er the metabolism and toxicity of solvents.

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Section: Phenobarbital As a Clue To The Underlying Mechanism Of The Dmentioning

confidence: 73%

Pharmacokinetics of organic solvent vapors in relation to their toxicity.

Sato¹,

Nakajima²

1987

Scand J Work Environ Health

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“…The induction of benzene hydroxylase, a member of cytochrome P-450 dependent drug metabolizing enzymes, was first reported by Snyder and coworkers (Snyder et al 1967). However, benzene cannot be considered as a general inducer of drug metabolism, since some drug metabolizing enzyme activities such as aminopyrine N-demethylase (Post and Snyder 1983) and ethylmorphine O-dealkylase (Gollmer et al 1984) activities of liver microsomes have been reported unchanged.…”

Section: Resultsmentioning

confidence: 99%

Stimulatory effects of benzene on rabbit liver and kidney microsomal cytochrome P-450 dependent drug metabolizing enzymes

et al. 1991

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Treatment of rabbits with benzene (880 mg/kg/day), s.c. for 3 consecutive days, caused 3.8- and 5.7-fold increases in aniline 4-hydroxylation rates of liver and kidney microsomes, respectively. Benzene treatment markedly enhanced hydroxylation rats of p-nitrophenol by liver and kidney by 7.2- and 4.2-fold, respectively. Both of these enzymes are associated with cytochrome P-450 LM3a. In contrast, the activity of benzphetamine N-demethylase, associated with P-450 LM2, was not altered significantly in either liver or kidney microsomes. Although the total cytochrome P-450 contents of liver and kidney microsomes were not altered significantly by the benzene treatment, in the case of liver microsomes, formation of a new cytochrome P-450 with an apparent Mr of 51,400 was observed on SDS-PAGE. On the other hand, in the kidney microsomes, the intensity of the bands corresponding to approximate Mr of 50,000 and 51,400 was markedly increased. The results of the present work, in combination with those of the previous work (Arinç et al. 1988), indicate the existence of tissue specificity in the induction of rabbit P-450 isozyme by benzene.

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“…It has been well established that benzene can induce its own metabolism by cytochrome P450 in rat, mouse, and rabbit liver microsomes (Snyder et al, 1967;Saito et al, 1970;Gonasun et al, 1973). Post and Snyder (1983) showed that benzene was metabolized by at least two forms of CYP450 in rat liver microsomes.…”

Section: Benzene Metabolismmentioning

confidence: 99%