The Metabolism and Significance of Homocysteine in Cardiovascular Health: Mini Reviews

Dietrich, U; Gyftodimos, Fragiskos; Ghoti, Enas; Ghoti, Israa; Fyrilla, Maria; Patrikios, Ioannis

doi:10.37515/oncology.7632.1102

Cited by 3 publications

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“…Homocysteine is a nonproteinogenic, sulfur‐containing amino acid, derived from methionine via transmethylation reaction. The reaction is catalyzed by S‐Adenosyl‐L–Methionine synthase (SAM), L‐Methionine Adenosyl Transferase, Methyltransferase (MT) and S‐Adenosyl‐L‐Homocysteine Hydrolase [1]. Homocysteine is involved in three main pathways in methionine metabolism.…”

Section: Introductionmentioning

confidence: 99%

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S‐Adenosyl‐L‐Homocysteine Hydrolase Immobilized on Citric Acid‐capped Gallium Oxyhydroxide on SWCNTs Modified Electrode for AdoHcy Impedimetric Sensing

et al. 2021

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S‐Adenosyl‐L‐Homocysteine (AdoHcy) is a crucial pathological factor in homocysteine‐associated disorders. We developed an impedimetric approach for single drop S‐Adenosyl‐L‐Homocysteine detection, based on S‐Adenosyl‐L‐Homocysteine hydrolase (SAH), produced in the prokaryotic expression system (E. coli) by recombinant DNA technology, immobilized on citrate acid‐coated gallium oxyhydroxide dispersed over single‐walled carbon nanotubes (CA/GaO(OH)@SWCNT). The proposed biosensor offers detection of AdoHcy, with a limit of detection (LOD) of 0.17 μM. with operating linear range from 1 to 44 μM. The remarkable stability of gallium oxyhydroxide crystal was further improved by citric acid coating and its optical, electrical and physical anisotropy was skipped using SWCNTs.

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Section: Introductionmentioning

confidence: 99%

“…It can also transform into cysteine, which can enter the urea cycle and be excreted by urine, form proteins or be transformed into α‐ketoglutarate which enters the citric acid cycle and is involved in ATP production. Excess homocysteine is excreted to the extracellular matrix [1]. Homocysteine plasma levels are between 5 and 15 μmol/L.…”

Section: Introductionmentioning

confidence: 99%

S‐Adenosyl‐L‐Homocysteine Hydrolase Immobilized on Citric Acid‐capped Gallium Oxyhydroxide on SWCNTs Modified Electrode for AdoHcy Impedimetric Sensing

et al. 2021

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A micronutrient supplement modulates homocysteine levels regardless of vitamin B biostatus in elderly subjects

Savic-Hartwig

Kerlikowsky

Flierdt

et al. 2024

International Journal for Vitamin and Nutrition Research

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Abstract. Elevated homocysteine (Hcy) levels (≥15 μmol/L) in the elderly are frequently associated with a higher risk of cardiovascular disease and cognitive decline. Several studies have already shown an Hcy-lowering effect of B vitamin supplementation in cohorts deficient in these nutrients. The aim of this randomized, double-blinded 12-week intervention study was to investigate whether Hcy levels in healthy elderly subjects (75.4±4.5 years, n=133) could be lowered with a micronutrient supplement (i.e., 400 μg folic acid, 100 μg cobalamin). Difference in mean initial Hcy levels between intervention (17.6±7.1 μmol/L, n=65) and placebo group (18.9±6.1 μmol/L, n=68) was not significant. The prevalence of cobalamin and folate deficiency in the total study population was low: 27% had serum-cobalamin levels ≤150 pmol/L, 12% holo-transcobalamin (Holo-TC) levels ≤50 pmol/L, 13% low cobalamin status using the aggregated cobalamin marker 4cB12 and 10% red blood cell (RBC) folate ≤570 nmol/L. Nevertheless, the treated subjects still showed improved cobalamin and folate biostatus (serum cobalamin Δt12-t0: 63±48 pmol/L; Holo-TC Δt12-t0: 17±19 pmol/L; RBC folate Δt12-t0: 326±253 nmol/L) and Hcy levels (Δt12-t0: −3.6±5.7 μmol/L). The effects were statistically significant compared to the placebo group with p=0.005 (serum cobalamin), p=0.021 (Holo-TC), p=0.014 (RBC-folate) and p<0.001 (Hcy). The Hcy-lowering effect was dependent on the initial Hcy levels (p<0.001). Our findings suggest that elevated Hcy levels in elderly subjects can be lowered regardless of the initial cobalamin and folate biostatus.

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Tayma and the sea – marine goods in an Arabian oasis settlement

Prust

2020

Polish Archaeology in the Mediterranean

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Marine goods found in the oasis of Taymāʾ (Northwest Arabia), 300 km away from the nearest coast of the Red Sea, illustrate the economic importance and prosperity of the site. Excavations of the Saudi-German collaborative project revealed 631 marine specimens of 5 animal classes: coral, gastropods, bivalves, scaphopods and fish. The finds origin from various contexts (burial ground, public buildings, private houses and agricultural areas) and encompass occupation periods from the 3rd millennium BC to the 7th century AD onwards with an increased incidence of shell artefacts from the 11th to the 9th century AD. Variety and quantity of these goods within specific contexts urge new reflections on utilisation, commerce and transport.

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The Metabolism and Significance of Homocysteine in Cardiovascular Health: Mini Reviews

Cited by 3 publications

References 0 publications

S‐Adenosyl‐L‐Homocysteine Hydrolase Immobilized on Citric Acid‐capped Gallium Oxyhydroxide on SWCNTs Modified Electrode for AdoHcy Impedimetric Sensing

S‐Adenosyl‐L‐Homocysteine Hydrolase Immobilized on Citric Acid‐capped Gallium Oxyhydroxide on SWCNTs Modified Electrode for AdoHcy Impedimetric Sensing

A micronutrient supplement modulates homocysteine levels regardless of vitamin B biostatus in elderly subjects

Tayma and the sea – marine goods in an Arabian oasis settlement

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