The metabolic syndrome: is it the mother's fault?

Schmerbach, Kristin; Patzak, Andreas

doi:10.1111/apha.12230

Cited by 2 publications

(4 citation statements)

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“…Furthermore, it has been shown to increase the risk of type 2 diabetes onset. However, this syndrome could be minimized, or even eluded, because the associated metabolic deficiencies are related to an unhealthy lifestyle [6,7].…”

Section: Introductionmentioning

confidence: 99%

Diet-Induced Rabbit Models for the Study of Metabolic Syndrome

Lozano

Arias-Mutis

Calvo

et al. 2019

Animals

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Obesity and metabolic syndrome (MetS) have become a growing problem for public health and clinical practice, given their increased prevalence due to the rise of sedentary lifestyles and excessive caloric intake from processed food rich in fat and sugar. There are several definitions of MetS, but most of them describe it as a cluster of cardiovascular and metabolic alterations such as abdominal obesity, reduced high-density lipoprotein (HDL) and elevated low-density lipoprotein (LDL) cholesterol, elevated triglycerides, glucose intolerance, and hypertension. Diagnosis requires three out of these five criteria to be present. Despite the increasing prevalence of MetS, the understanding of its pathophysiology and relationship with disease is still limited. Indeed, the pathological consequences of MetS components have been reported individually, but investigations that have studied the effect of the combination of MeS components on organ pathological remodeling are almost nonexistent. On the other hand, animal models are a powerful tool in understanding the mechanisms that underlie pathological processes such as MetS. In the first part of the review, we will briefly overview the advantages, disadvantages and pathological manifestations of MetS in porcine, canine, rodent, and rabbit diet-induced experimental models. Then, we will focus on the different dietary regimes that have been used in rabbits to induce MetS by means of high-fat, cholesterol, sucrose or fructose-enriched diets and their effects on physiological systems and organ remodeling. Finally, we will discuss the use of dietary regimes in different transgenic strains and special rabbit breeds.

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Section: Introductionmentioning

confidence: 99%

Diet-Induced Rabbit Models for the Study of Metabolic Syndrome

Lozano

Arias-Mutis

Calvo

et al. 2019

Animals

View full text Add to dashboard Cite

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“…, Kirk et al . , Schmerbach & Patzak ). After Hales and Barker reported low birthweight as a strong risk factor for metabolic dysfunction, several studies afterwards found evidence that the maternal body composition could lead to permanent metabolic and physiological alterations during the perinatal development, resulting in increased risk for type 2 diabetes and metabolic syndrome in the offspring (Hales & Barker ).…”

mentioning

confidence: 98%

“…, Kjaergaard et al . , Ong & Muhlhausler , Schmerbach & Patzak ). Maternal body mass index (BMI), excessive gestational weight gain (GWG) and maternal gestational diabetes are related to higher body fat mass in older children, higher childhood blood pressure and plasma cardiovascular biomarkers (Poston , West et al .…”

mentioning

confidence: 99%

“…The worldwide prevalence of obesity rises dramatically among children, adolescents and adults, not only in the Western countries but also in other countries (Seidell ). The WHO expects about 300 million people worldwide suffering from metabolic syndrome and associated disorders in the year 2025 (Seidell , Schmerbach & Patzak ). The metabolic syndrome also called syndrome X is defined by obesity and several cardiovascular risk factors such as lipid abnormalities, high blood pressure and impaired glucose tolerance as well as a pro‐inflammatory and prothrombotic state (Alberti et al .…”

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confidence: 99%

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