The Metabolic Syndrome

Cowey, Stephanie; Hardy, Robert W.

doi:10.2353/ajpath.2006.051090

Cited by 383 publications

(152 citation statements)

References 75 publications

(101 reference statements)

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“…Several mechanisms have been proposed regarding the effect of the metabolic syndrome on the risk of colorectal adenomas, including obesity [41], oxidative stress [42], inflammation [43], and insulin resistance [44,45]. In support of results reported in previous studies [13,14,15,16,17,18], the present study showed that the metabolic syndrome itself and its individual components (i.e.…”

Section: Discussionsupporting

confidence: 81%

The Metabolic Syndrome Is Associated with an Increased Risk of Colorectal Polyps Independent of Plasma Homocysteine

et al. 2014

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Background/Aims: The links between the metabolic syndrome and homocysteine in relation to the risk of colorectal polyps are not understood. The purpose of this study was to investigate the association between the metabolic syndrome and homocysteine and further analyze the relationship between these two factors and the risk of colorectal polyps. Methods: This was a case-control study. A total of 135 participants with colorectal polyps (cases) and 110 participants without polyps (controls) were recruited. Results: There were 59 participants with the metabolic syndrome in the case group and 36 participants with the metabolic syndrome in the control group. The metabolic syndrome and its individual components, except for serum triglycerides, and homocysteine were associated with the risk of colorectal polyps. When the association of the metabolic syndrome and homocysteine with the risk of colorectal polyps was simultaneously considered, the association between homocysteine and the risk of colorectal polyps disappeared, but waist circumference, systolic and diastolic blood pressure, high-density lipoprotein cholesterol, and the metabolic syndrome itself were still significant risk factors for the development of colorectal polyps. Conclusion: Although the metabolic syndrome and plasma homocysteine were individually related to the risk of colorectal polyps, the metabolic syndrome was a major contributing factor in relation to the risk of colorectal polyps independent of plasma homocysteine.

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Section: Discussionsupporting

confidence: 81%

The Metabolic Syndrome Is Associated with an Increased Risk of Colorectal Polyps Independent of Plasma Homocysteine

et al. 2014

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“…Obesity is accompanied with the up-regulation of various cellular proliferation pathways [35]. Adipokines and estrogens, produced in adipose tissue, may enhance tumor cell proliferation and metastasis [35,36,37], and may potentially result in more aggressive ER-positive cancers in postmenopausal women [16]. …”

Section: Discussionmentioning

confidence: 99%

Impact of Body Mass Index on Prognostically Relevant Breast Cancer Tumor Characteristics

Eichholzer

Huang²,

Modlasiak³

et al. 2013

Breast Care

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Background: This study analyzes the association of body mass index (BMI) and prognostically relevant breast cancer (BC) characteristics in a country that has been rather spared of the global obesity epidemic. Patients and Methods: Based on 20-year data (1999-2009, n = 1,414) of the prospective relational BC database of the University Hospital Basel, Switzerland, the associations between BMI, tumor size and stage, histological subtype, grading, hormonal receptor status, HER2 status and ‘triple-negative' status were evaluated. Multivariate analysis considered BMI and patient's age. Results: The association between increasing BMI and the above-mentioned variables were as follows (results described in each case: Beta-coefficient or odds ratio, 95% confidence interval, p value): tumor size, (1) entire cohort: 0.03 (0.01-0.05), p < 0.001, (2) tumor found by self-palpation: 0.05 (0.03-0.07), p < 0.001, (3) tumor found by radiological examination: 0.03 (0-0.07), p = 0.044; advanced TNM stage: 1.16 (1.02-1.31), p = 0.022; histological subtype: 1.04 (0.89-1.22), p = 0.602; unfavorable grading: 1.11 (1.00-1.25), p = 0.057; positive estrogen receptor status: 0.95 (0.83-1.09), p = 0.459; positive HER2 status: 0.92 (0.74-1.15), p = 0.467; presence of a ‘triple-negative' carcinoma: 1.19 (0.93-1.52), p = 0.165. Consideration of only postmenopausal BC patients (n = 1,063) did attenuate the results, but did not change the direction of the associations with BMI. Conclusion: BMI was positively associated with TNM stage, grading and tumor size for tumors that were found by self-detection, as well as for those lesions detected by radiological breast examinations.

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“…This syndrome is defined by insulin insensitivity, abnormal glucose levels, elevated lipid and blood pressure levels and increased waist circumference [8]. Metabolic syndrome is associated with an increased risk of cardiovascular disease [9], diabetes [10], and some cancers such as colorectal, breast, and prostate cancers [11][12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Association of metabolic syndrome with insulin-like growth factors among adults in the US

Saydah¹,

Ballard‐Barbash

Potischman

2009

Cancer Causes Control

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The Metabolic Syndrome

Cited by 383 publications

References 75 publications

The Metabolic Syndrome Is Associated with an Increased Risk of Colorectal Polyps Independent of Plasma Homocysteine

The Metabolic Syndrome Is Associated with an Increased Risk of Colorectal Polyps Independent of Plasma Homocysteine

Impact of Body Mass Index on Prognostically Relevant Breast Cancer Tumor Characteristics

Association of metabolic syndrome with insulin-like growth factors among adults in the US

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