The Metabolic Syndrome and Its Individual Components: Its Association with Venous Thromboembolism in a Mediterranean Population

Vayá, Amparo; Martínez-Triguero, María L.; España, Francisco; Todolí, José; Bonet, Elena; Corella, Dolores

doi:10.1089/met.2010.0117

Cited by 33 publications

(31 citation statements)

References 26 publications

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“…The inter-observer agreement for the study selection was excellent, with a k of 0.92. After the selection process, eight studies were eligible for this analysis (15,17,18,19,20, 21,22,23), six were case-control studies (15,17,18,21,22,23) and two were prospective cohort studies (19,20). All contacted investigators agreed to provide their full database of the study.…”

Section: Resultsmentioning

confidence: 99%

“…The interaction of these risk factors results in a significantly increased risk of developing coronary artery disease and ischemic stroke (14). Recent studies suggest that the metabolic syndrome may also be associated with VTE (15-21), but several issues remain unclear. In particular, whether this association is attributable to the metabolic syndrome or to abdominal obesity alone, with no additional contribution by the other components, and whether this association is gender specific remain to be established (19,20).…”

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confidence: 99%

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Association Between the Metabolic Syndrome, Its Individual Components, and Unprovoked Venous Thromboembolism

Ageno

Minno

et al. 2014

ATVB

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Objective The metabolic syndrome (MetS) may contribute to the pathogenesis of venous thromboembolism (VTE), but this association requires additional investigation. Approach and Results We performed a patient-level meta-analysis of case-control and cohort studies that evaluated the role of MetS and risk of unprovoked VTE. For case-control studies, odds ratios (ORs) and 95% confidence intervals (CI) were calculated using logistic regression analysis to estimate the influence of individual variables on the risk of VTE; Chi squared tests for trend were used to investigate the impact of increasing number of components of MetS on the risk of VTE, and to explore the influence of abdominal obesity on this relationship. For cohort studies, hazard ratios (HRs) and 95% CI were calculated by using multivariable Cox regression analysis. Six case-control studies were included (908 cases with unprovoked VTE and 1794 controls): in multivariate analysis, MetS was independently associated with VTE (OR 1.91, 95% 1.57-2.33) and both MetS and abdominal obesity were better predictors of unprovoked VTE than obesity defined by the body mass index (BMI). Two prospective cohort studies were included (26.531 subjects, 289 unprovoked VTE events): age, obesity, and abdominal obesity, but not MetS were associated with VTE. Conclusions Case-control, but not prospective cohort studies support an association between MetS and VTE. Abdominal adiposity is a strong risk factor for VTE.

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Section: Resultsmentioning

confidence: 99%

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confidence: 99%

Association Between the Metabolic Syndrome, Its Individual Components, and Unprovoked Venous Thromboembolism

Ageno

Minno

et al. 2014

ATVB

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“…Previous studies have shown that obesity plays a pivotal role in the development of VTE related to MS [18,19]. Steffen et al [20] found MS was associated with incident VTE, but this was attributed to obesity instead of the other MS components.…”

Section: Discussionmentioning

confidence: 99%

Metabolic Syndrome and Deep Vein Thrombosis After Total Knee and Hip Arthroplasty

Song

Rong

Yao

et al. 2016

The Journal of Arthroplasty

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“…5,6 Moreover, the incidence of venous thromboembolism correlates with epicardial fat thickness 7 and abdominal obesity. 8 Additional important risk factors for venous thromboembolism in obese patients include inflammation, decreased fibrinolysis, increased thrombin generation, and platelet hyperactivity. 9 Interventions such as diet, exercise, and gastric bypass surgery not only result in weight loss and reduced visceral adipose tissue mass, but also improve insulin sensitivity, delay the onset of T2D, and prevent cardiovascular disease.…”

Section: Introductionmentioning

confidence: 99%

Inflammation, obesity, and thrombosis

Samad

Ruf

2013

Blood

332

229

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Clinical and epidemiological studies support a connection between obesity and thrombosis, involving elevated expression of the prothrombotic molecules plasminogen activator inhibitor-1 and tissue factor (TF) and increased platelet activation. Cardiovascular diseases and metabolic syndrome–associated disorders, including obesity, insulin resistance, type 2 diabetes, and hepatic steatosis, involve inflammation elicited by infiltration and activation of immune cells, particularly macrophages, into adipose tissue. Although TF has been clearly linked to a procoagulant state in obesity, emerging genetic and pharmacologic evidence indicate that TF signaling via G protein-coupled protease-activated receptors (PAR2, PAR1) additionally drives multiple aspects of the metabolic syndrome. TF–PAR2 signaling in adipocytes contributes to diet-induced obesity by decreasing metabolism and energy expenditure, whereas TF–PAR2 signaling in hematopoietic and myeloid cells drives adipose tissue inflammation, hepatic steatosis, and insulin resistance. TF-initiated coagulation leading to thrombin–PAR1 signaling also contributes to diet-induced hepatic steatosis and inflammation in certain models. Thus, in obese patients, clinical markers of a prothrombotic state may indicate a risk for the development of complications of the metabolic syndrome. Furthermore, TF-induced signaling could provide new therapeutic targets for drug development at the intersection between obesity, inflammation, and thrombosis.

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The Metabolic Syndrome and Its Individual Components: Its Association with Venous Thromboembolism in a Mediterranean Population

Abstract: We conclude that, in subjects with a mean age of 44 years, metabolic syndrome increases VTE risk, although abdominal obesity is the pivotal factor.

Cited by 33 publications

References 26 publications

Association Between the Metabolic Syndrome, Its Individual Components, and Unprovoked Venous Thromboembolism

Association Between the Metabolic Syndrome, Its Individual Components, and Unprovoked Venous Thromboembolism

Metabolic Syndrome and Deep Vein Thrombosis After Total Knee and Hip Arthroplasty

Inflammation, obesity, and thrombosis

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