The metabolic analysis of psoriasis identifies the associated metabolites while providing computational models for the monitoring of the disease

Abstract

The majority of studies on psoriasis have focused on explaining the genetic background and its associations with the immune system’s response. The aim of this study was to identify the low-molecular weight compounds contributing to the metabolomic profile of psoriasis and to provide computational models that help with the classification and monitoring of the severity of the disease. We compared the results from targeted and untargeted analyses of patients’ serums with plaque psoriasis to controls. The main differences were found in the concentrations of acylcarnitines, phosphatidylcholines, amino acids, urea, phytol, and 1,11-undecanedicarboxylic acid. The data from the targeted analysis were used to build classification models for psoriasis. The results from this study provide an overview of the metabolomic serum profile of psoriasis along with promising statistical models for the monitoring of the disease.Electronic supplementary materialThe online version of this article (doi:10.1007/s00403-017-1760-1) contains supplementary material, which is available to authorized users.

Hyperproliferation is the main driver of metabolomic changes in psoriasis lesional skin

“…In parallel, the ratio of Orn to Arg in lesional skin was decreased compared to controls suggesting lower arginase activity in PS lesions. The ratio of citrulline to Orn was also lower in PS-L skin compared to PS-NL skin and C being consistent to the lower activity of ornithine carbamoyltransferase found previously in the blood of psoriasis patients 21 . Of note, the levels of citrulline and Orn did not differ significantly between the three groups.…”

“…In addition Lys is required for biosynthesis of L-carnitine (Car) that was also increased in psoriasis lesions (our data and 20 ). The increase in Glu and Phe levels are well corroborated by the previously found increase of these AAs in the blood of psoriasis patients 21 .…”

“…SO) and therefore functions as a marker for oxidative stress 23 . Ottas et al found that Met.SO level and Met.SO ratio to Met were significantly higher in psoriasis patients blood compared to controls 21 . In this work we found no significant differences in Met.SO levels between PS-L and C skin samples suggesting that there is no excessive protein-related oxidative stress in psoriatic skin lesions.…”

(R)-Salbutamol Improves Imiquimod-Induced Psoriasis-Like Skin Dermatitis by Regulating the Th17/Tregs Balance and Glycerophospholipid Metabolism

“…Previous studies showed that altered small molecules metabolism play key roles in the immune dysfunction in autoimmune diseases, including psoriasis, systemic lupus erythematosus, and rheumatoid arthritis [48,49]. In the untargeted metabolomics, employing multivariate statistical analysis, alterations in metabolites that are involved in the IMQ-induced psoriasis were identified.…”

“…Phosphatidylcholines (PC) and phosphatidylserine (PS) are the main glycerophospholipids found in the phospholipid membranes [50]. Recent studies revealed that the higher proliferation rates of skin cells could also explain the lower concentrations of PC in psoriasis plasma, which is an essential component of cell membranes [49]. Furthermore, reduced levels of PS were found in active psoriasis [51].…”