The Metabolic Activity of Caudate and Prefrontal Cortex Negatively Correlates with the Severity of Idiopathic Parkinson’s Disease

Chu, Junsheng; Liu, Tinghong; Wang, Kailiang; Han, Chun-Lei; Liu, Yunpeng; Shimabukuro, Michio; Zhang, Jianguo; Tie, Fang; Meng, Fangang

doi:10.14336/ad.2018.0814

Cited by 20 publications

(13 citation statements)

References 37 publications

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“…In addition, acupuncture could also play a protective role in cranial nerves by regulating blood pressure and improving cerebral circulation ( 57 , 58 ). Some of the above mechanisms have also been confirmed by imaging-based research in PD patients ( 50 , 59 ). Overall, acupuncture, like other neuroprotective agents, is anti-inflammatory, antioxidative, antiapoptotic, and neurotrophic, and the advantage of acupuncture therapy lies in having either specific target mechanisms of action or multitarget mechanisms of action ( 46 ).…”

Section: Discussionmentioning

confidence: 64%

Effectiveness of Acupuncture in the Treatment of Parkinson's Disease: An Overview of Systematic Reviews

et al. 2020

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Background: The effects of acupuncture on Parkinson's disease (PD) outcomes remain unclear. The aim of this overview was to comprehensively evaluate the methodological quality and applicability of the results of systematic reviews (SRs)/meta-analyses (MAs) that examined the use of acupuncture to treat PD. Methods: Eight databases were searched to retrieve SRs/MAs on the use of acupuncture for the treatment of PD. Two reviewers independently screened and extracted the data using the Assessing the Methodological Quality of Systematic Reviews 2 (AMSTAR-2) checklist to evaluate the methodological quality and using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) criteria to assess the evidence quality of the included reviews. Results: A total of 11 SRs/MAs were included. According to the AMSTAR-2 checklist results, all included SRs/MAs were rated as very-low-quality studies. The GRADE criteria revealed 20 studies with very-low-quality evidence, 9 with low-quality evidence, 3 with moderate-quality evidence, and 0 with high-quality evidence. Descriptive analysis showed that acupuncture appears to be a clinically effective and safe treatment for PD. Conclusions: The use of acupuncture for the treatment of PD may be clinically effective and safe. This conclusion must be interpreted cautiously due to the generally low methodological quality and low quality of evidence of the included studies.

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Section: Discussionmentioning

confidence: 64%

Effectiveness of Acupuncture in the Treatment of Parkinson's Disease: An Overview of Systematic Reviews

et al. 2020

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“…We note that all these fiber tracts have connections with either the prefrontal cortex, the parietal cortex, or the basal ganglia, i.e., the brain regions implicated in cognitive switching (Leh et al, 2007 , 2010 ). Intriguingly, degradation of these white matters has also been observed in patients with Parkinson's disease (Taylor et al, 2018 ; Lenka et al, 2020 ), a neurological disorder disrupting functional connectivity and metabolism of the dopaminergic fronto-striatal pathways (Wichmann and DeLong, 2013 ; Monnot et al, 2017 ; Chu et al, 2019 ). Patients with Parkinson's disease often present poor task-switching performance (Cools et al, 2001 ; Cameron et al, 2010 ).…”

Section: Introductionmentioning

confidence: 99%

Integrity of the Prefronto-striato-thalamo-prefrontal Loop Predicts Tai Chi Chuan Training Effects on Cognitive Task-switching in Middle-aged and Older Adults

Tang

Tseng

et al. 2021

Front. Aging Neurosci.

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Tai Chi Chuan (TCC) exercise has been shown to improve cognitive task-switching performance in older adults, but the extent of this positive effect varies among individuals. Past research also shows that brain white matter integrity could predict behavioral gains of cognitive and motor learning. Therefore, in this randomized controlled trial (NCT02270320), we examined whether baseline integrity of three target white matter tract groups was predictive of task-switching improvement after 12-week TCC training in middle-aged and older adults. Thirty-eight eligible participants were randomly assigned to a TCC group (n = 19) and a control group (n = 19). Cognitive task-switching and physical performances were collected before and after training. Brain diffusion spectrum MR images were acquired before training and the general fractional anisotropy (GFA) of each target white matter tract group was calculated to indicate baseline white matter integrity of that group. Correlation and regression analyses between these GFAs and post-training task-switching improvement were analyzed using adjusted p-values. After 12 weeks, significant task-switching and physical performance improvements were found only in the TCC group. Moreover, higher baseline GFA of the prefronto-striato-thalamo-prefrontal loop fibers (r = −0.63, p = 0.009), but not of the prefronto-parietal/occipital (r = −0.55, p = 0.026) and callosal (r = −0.35, p = 0.189) fiber groups, was associated with greater reductions of task-switching errors after the TCC training. Multiple regression analysis revealed that baseline GFA of the prefronto-striato-thalamo-prefrontal loop fibers was the only independent white matter integrity predictor of task-switching error reductions after TCC training (β = −0.620, adjusted R2 change = 0.265, p = 0.009). These findings not only highlight the important role of baseline integrity of the prefronto-striatal circuits in influencing the extent of positive cognitive task-switching effects from short-term TCC training, but also implicate that preserving good white matter integrity in the aging process may be crucial in order to gain the best cognitive effects of exercise interventions.

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“…In addition to spinal circuits and the peripheral neuromuscular system—which have been the primary foci of most traditional therapeutic efforts—the regulation of balance is also dependent upon numerous sensory, motor, and cognitive brain networks that enable selective attention to appropriate aspects of the visual field, the integration of numerous sensory inputs, selection of the appropriate walking speed, the ability to stand while performing necessary cognitive tasks, and numerous other functions that enable one to perform complex texts and navigate ever-changing environments (Lajoie et al, 1996 ; Yogev-Seligmann et al, 2008 ; Mirelman et al, 2014 ; Wollesen et al, 2016 ; Zhou et al, 2019 ). Aging and age-related diseases including Parkinson's disease and dementia are associated with both anatomical and biophysiological changes (Jové et al, 2014 ; Chu et al, 2019 ) that interact with aging and further alter brain network function (Chun et al, 2000 ; Benedetti et al, 2006 ; Beheshti et al, 2020 ) and balance control (Mahncke et al, 2006 ; Fjell et al, 2009 ). Strategies targeting these supraspinal elements of balance control therefore hold great promise to improve balance, safety, and independence within vulnerable older adult populations.…”

Section: Introductionmentioning

confidence: 99%

The Effects of Transcranial Direct Current Stimulation (tDCS) on Balance Control in Older Adults: A Systematic Review and Meta-Analysis

Guo

Bao

Manor

et al. 2020

Front. Aging Neurosci.

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Background: Recently, considerable research has been conducted to study the effects of transcranial direct current stimulation (tDCS) on balance control in older adults. We completed a comprehensive systematic review and meta-analysis to assess the efficacy of tDCS on balance control in this population. Methods: A search strategy based on the PICOS principle was used to find the literatures in the databases of PubMed, EMBASE, EBSCO, Web of Science. The quality and risk of bias in the studies were independently assessed by two researchers. Results: Ten studies were included in the systematic review. A meta-analysis was completed on six of these ten, with a total of 280 participants. As compared to sham (i.e., control), tDCS induced significant improvement with low heterogeneity in balance control in older adults. Specifically, tDCS induced large effects on the performance of the timed-up-and-go test, the Berg balance scale, and standing postural sway (e.g., sway area) and gait (e.g., walking speed) in dual task conditions (standardized mean differences (SMDs) = −0.99∼3.41 95% confidence limits (CL): −1.52∼4.50, p < 0.006, I 2 < 52%). Moderate-to-large effects of tDCS were also observed in the standing posture on a static or movable platform (SMDs = 0.37∼1.12 95%CL: −0.09∼1.62, p < 0.03, I 2 < 62%). Conclusion: Our analysis indicates that tDCS holds promise to promote balance in older adults. These results warrant future studies of larger sample size and rigorous study design and results report, as well as specific research to establish the relationship between the parameter of tDCS and the extent of tDCS-induced improvement in balance control in older adults.

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The Metabolic Activity of Caudate and Prefrontal Cortex Negatively Correlates with the Severity of Idiopathic Parkinson’s Disease

Cited by 20 publications

References 37 publications

Effectiveness of Acupuncture in the Treatment of Parkinson's Disease: An Overview of Systematic Reviews

Effectiveness of Acupuncture in the Treatment of Parkinson's Disease: An Overview of Systematic Reviews

Integrity of the Prefronto-striato-thalamo-prefrontal Loop Predicts Tai Chi Chuan Training Effects on Cognitive Task-switching in Middle-aged and Older Adults

The Effects of Transcranial Direct Current Stimulation (tDCS) on Balance Control in Older Adults: A Systematic Review and Meta-Analysis

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