The Meta VCI Map consortium for meta‐analyses on strategic lesion locations for vascular cognitive impairment using lesion‐symptom mapping: Design and multicenter pilot study

Weaver, Nick A.; Zhao, Lei; Biesbroek, J. Matthijs; Kuijf, Hugo J.; Aben, Hugo P.; Bae, Hee‐Joon; Caballero, Miguel Ángel Araque; Chappell, Francesca M; Chen, Christopher; Dichgans, Martin; Duering, Marco; Georgakis, Marios K.; Giessen, Ruben S. van der; Gyanwali, Bibek; Hamilton, Olivia; Hilal, Saima; Hofe, Elise M Vom; Kort, Paul L.M. de; Koudstaal, Peter J.; Lam, Bonnie Yin Ka; Lim, Jae Sung; Makin, Stephen; Mok, Vincent C.T.; Shi, Lin; Hernández, Maria C. Valdés; Venketasubramanian, Narayanaswamy; Wardlaw, Joanna M.; Wollenweber, Frank Arne; Wong, Adrian; Xu, Xiaoyan; Biessels, Geert Jan

doi:10.1016/j.dadm.2019.02.007

Cited by 34 publications

(41 citation statements)

References 76 publications

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“…In addition, efforts should be made to increase the sample size of lacunar stroke patients, to increase the reliability and power of the statistical analysis. Creating an international database could provide a promising solution to the small sample sizes which most of the recent literature on lacunar or other mild cortical strokes lists as a limitation, initiated either as a new project or as a branch of a project/consortia like the PLORAS database ( 46 ) or the Meta VCI Map consortium ( 17 ). A range of cognitive tests has been used by different studies making comparison between studies challenging.…”

Section: Discussionmentioning

confidence: 99%

“…The general impact of infarct location on cognition has been studied in relation to stroke lesion volume ( 13 ), shape ( 14 ), white matter hyperintensity (WMH) volume ( 15 ), post-stroke depression and behavioral disorders ( 16 ). A large multi-center study found that infarcts (i.e., cortical and subcortical) affecting the basal ganglia and internal capsule were associated with impairment of global cognition ( 17 ), in a sample of 878 patients with ischemic stroke. Ischemic strokes' lesions in both brain hemispheres have been associated with lower performances in visuospatial and executive functions ( 7 ).…”

Section: Introductionmentioning

confidence: 99%

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Post-stroke Cognition at 1 and 3 Years Is Influenced by the Location of White Matter Hyperintensities in Patients With Lacunar Stroke

et al. 2021

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Lacunar strokes are a common type of ischemic stroke. They are known to have long-term cognitive deficits, but the influencing factors are still largely unknown. We investigated if the location of the index lacunar stroke or regional WMH and their change at 1 year could predict the cognitive performance at 1 and 3 years post-stroke in lacunar stroke patients. We used lacunar lesion location and WMH-segmented data from 118 patients, mean age 64.9 who had a brain MRI scan soon after presenting with symptoms, of which 88 had a repeated scan 12 months later. Premorbid intelligence (National Adult Reading Test) and current intelligence [Addenbrooke's Cognitive Exam-Revised (ACE-R)] were measured at 1, 12, and 36 months after the stroke. ANCOVA analyses adjusting for baseline cognition/premorbid intelligence, vascular risk factors, age, sex and total baseline WMH volume found that the recent small subcortical infarcts (RSSI) in the internal/external capsule/lentiform nucleus and centrum semiovale did not predict cognitive scores at 12 and 36 months. However, RSSI location moderated voxel-based associations of WMH change from baseline to 1 year with cognitive scores at 1 and 3 years. WMH increase in the external capsule, intersection between the anterior limb of the internal and external capsules, and optical radiation, was associated with worsening of ACE-R scores 1 and 3 years post-stroke after accounting for the location of the index infarct, age and baseline cognition.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Post-stroke Cognition at 1 and 3 Years Is Influenced by the Location of White Matter Hyperintensities in Patients With Lacunar Stroke

et al. 2021

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“…20 First, acute infarcts were manually segmented on DWI (97.5%) or FLAIR (2.5%) sequences using in-house developed software built in MeVisLab (MeVis Medical Solutions AG, Bremen, Germany). 21 Next, all scans and the corresponding lesion maps were transformed to the T1 1-mm MNI-152 brain template 22 with the RegLSM tool (www.metavcimap.org/features/software-tools; most recent version described in Weaver et al 23 ). Quality checks of all registration results were performed by one rater (N.A.W.).…”

Section: Generation Of Infarct Mapsmentioning

confidence: 99%

Post-stroke cognitive impairment on the Mini-Mental State Examination primarily relates to left middle cerebral artery infarcts

Weaver

Kancheva

Lim

et al. 2021

International Journal of Stroke

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Background Post-stroke cognitive impairment can occur after damage to various brain regions, and cognitive deficits depend on infarct location. The Mini-Mental State Examination (MMSE) is still widely used to assess post-stroke cognition, but it has been criticized for capturing only certain cognitive deficits. Along these lines, it might be hypothesized that cognitive deficits as measured with the MMSE primarily involve certain infarct locations. Aims This comprehensive lesion-symptom mapping study aimed to determine which acute infarct locations are associated with post-stroke cognitive impairment on the MMSE. Methods We examined associations between impairment on the MMSE (<5th percentile; normative data) and infarct location in 1198 patients (age 67 ± 12 years, 43% female) with acute ischemic stroke using voxel-based lesion-symptom mapping. As a frame of reference, infarct patterns associated with impairments in individual cognitive domains were determined, based on a more detailed neuropsychological assessment. Results Impairment on the MMSE was present in 420 patients (35%). Large voxel clusters in the left middle cerebral artery territory and thalamus were significantly (p < 0.01) associated with cognitive impairment on the MMSE, with highest odds ratios (>15) in the thalamus and superior temporal gyrus. In comparison, domain-specific impairments were related to various infarct patterns across both hemispheres including the left medial temporal lobe (verbal memory) and right parietal lobe (visuospatial functioning). Conclusions Our findings indicate that post-stroke cognitive impairment on the MMSE primarily relates to infarct locations in the left middle cerebral artery territory. The MMSE is apparently less sensitive to cognitive deficits that specifically relate to other locations.

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“…Lesion segmentations were subsequently checked and adapted by two experienced raters (N.A.W., J.M.B). Subsequently, images as well as corresponding lesion maps were linearly and non-linearly normalized to Montreal Neurological Institute (MNI-152) space employing the RegLSM image processing pipeline (public code: http://lsm.isi.uu.nl/; Weaver et al, 2019).…”

Section: Neuroimaging Data Preprocessingmentioning

confidence: 99%

Generative lesion pattern decomposition of cognitive impairment after stroke

Bonkhoff

Lim

Bae

et al. 2020

Preprint

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SummaryCognitive impairment is a frequent and disabling sequela of stroke. There is however incomplete understanding of how lesion topographies in the left and right cerebral hemisphere brain interact to cause distinct cognitive deficits. We integrated machine learning and Bayesian hierarchical modeling to enable hemisphere-aware analysis of 1080 subacute ischemic stroke patients with deep profiling ∼3 months after stroke. We show relevance of the left hemisphere in the prediction of language and memory assessments, while global cognitive impairments were equally well predicted by lesion topographies from both sides. Damage to the hippocampal and occipital regions on the left were particularly informative about lost naming and memory function. Global cognitive impairment was predominantly linked to lesioned tissue in supramarginal and angular gyrus, the postcentral gyrus as well as the lateral occipital and opercular cortices of the left hemisphere. Hence, our analysis strategy uncovered that lesion patterns with unique hemispheric distributions are characteristic of how cognitive capacity is lost due to ischemic brain tissue damage.

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The Meta VCI Map consortium for meta‐analyses on strategic lesion locations for vascular cognitive impairment using lesion‐symptom mapping: Design and multicenter pilot study

Cited by 34 publications

References 76 publications

Post-stroke Cognition at 1 and 3 Years Is Influenced by the Location of White Matter Hyperintensities in Patients With Lacunar Stroke

Post-stroke Cognition at 1 and 3 Years Is Influenced by the Location of White Matter Hyperintensities in Patients With Lacunar Stroke

Post-stroke cognitive impairment on the Mini-Mental State Examination primarily relates to left middle cerebral artery infarcts

Generative lesion pattern decomposition of cognitive impairment after stroke

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