The Meta-Analysis in Evidence-Based Medicine: High-Quality Research When Properly Performed

Mahmood, Shazil; Nona, Paul; Villablanca, Pedro A.; Núñez‐Gil, Iván J.; Ramakrishna, Harish

doi:10.1053/j.jvca.2021.05.025

Cited by 2 publications

(3 citation statements)

References 22 publications

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“…We should realise that the same holds for the grades of evidence used in EBM ( Murad et al, 2014 ; Murad et al, 2016a ). More subtle is how the criteria used to judge the quality of RCTs ( Mahmood et al, 2021 ) influence the conclusions of meta-analyses up to becoming misleading ( Ioannidis, 2016 ). Although clinical judgment is difficult to define, its value was illustrated by the observation that the formal evaluation of biases in diagnostic accuracy by Quadas tools ( Whiting et al, 2011 ; Yang et al, 2021 ) is not much superior to clinical judgment.…”

Section: Methodsmentioning

confidence: 99%

Reconsidering evidence-based management of endometriosis

Koninckx¹,

Ussia²,

Al-Suwaidi³

et al. 2022

Facts Views Vis ObGyn

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Background: Without an adequate animal model permitting experiments the pathophysiology of endometriosis remains unclear and without a non-invasive diagnosis, information is limited to symptomatic women. Lesions are macroscopically and biochemically variable. Hormonal medical therapy cannot be blinded since recognised by the patient and the evidence of extensive surgery is limited because of the combination of low numbers of interventions of variable difficulty with variable surgical skills. Experience is spread among specialists in imaging, medical therapy, infertility, pain and surgery. In addition, the limitations of traditional statistics and p-values to interpret results and the complementarity of Bayesian inference should be realised. Objectives: To review and discuss evidence in endometriosis management Materials and Methods: A PubMed search for blinded randomised controlled trials in endometriosis. Results: Good-quality evidence is limited in endometriosis. Conclusions: Clinical experience remains undervalued especially for surgery. What is new? Evidence-based medicine should integrate traditional statistical analysis and the limitations of P-values, with the complementary Bayesian inference which is predictive and sequential and more like clinical medicine. Since clinical experience is important for grading evidence, specific experience in the different disciplines of endometriosis should be used to judge trial designs and results. Finally, clinical medicine can be considered as a series of experiments controlled by the outcome. Therefore, the clinical opinion of many has more value than an opinion.

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Section: Methodsmentioning

confidence: 99%

Reconsidering evidence-based management of endometriosis

Koninckx¹,

Ussia²,

Al-Suwaidi³

et al. 2022

Facts Views Vis ObGyn

View full text Add to dashboard Cite

show abstract

“…Evidence-based medicine refers to the integration of the best available research evidence combined with clinical expertise, knowledge and patients’ values and choices ( 8 , 9 ). Originally focused on critical appraisal and development of systematic reviews and clinical practice guidelines, EBM has become a key guiding principle for the investigation of clinical outcomes ( 10 ). According to the Oxford Centre for Evidence-Based Medicine, SR and MA are viewed as evidence with the highest quality level in EBM research ( 11 ).…”

Section: Introductionmentioning

confidence: 99%

“…Thus, MA can generate a large sample size that a single study cannot achieve due to the limitations of resources, time, or other factors. Additionally, MA can resolve potentially conflicting findings for the same topic from research ( 10 ). Both evidence-based methods give a comprehensive and precise review of a given topic providing guidance for further exploration.…”

Section: Introductionmentioning

confidence: 99%

Systematic reviews and meta-analyses on major depressive disorder: a bibliometric perspective

Chen

Feng

et al. 2023

Front. Psychiatry

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BackgroundThere is a vast amount of evidence-based medicine research on the major depressive disorder (MDD) available in the literature, however, no studies on the overall performance, productivity and impact of such research have been published to date. This study explored and mapped the research outputs of MDD-related systematic reviews and meta-analyses (SR/MA) from a bibliometric perspective.MethodsRelevant data were retrieved with search terms on MDD, systematic review and meta-analysis.ResultsA total of 4,870 papers with 365,402 citations published from 1983 to 2022 were included in the analysis. The publication output has grown steadily over time with the most publications originating from the USA (1,020; 20.94%), the UK (516; 10.60%) and China (448; 9.20%). The research collaborations between countries were most frequent between the USA and UK (266; 5.46%). Journal of Affective Disorders (379; 7.78%) was the most productive journal, while Cuijpers P was the most productive author (121; 2.48%), and University of Toronto (569; 11.78%) was the most productive institution. The top 10 most cited articles on MDD-related SR/MA had citations ranging from 1,806 to 3,448. The high-frequency keywords were mainly clustered into four themes, including psychiatric comorbidities, clinical trials, treatment, and brain stimulation in MDD.ConclusionThe rapid increase in the number of SR/MA of MDD in recent years highlights the importance of this research field. Psychiatric comorbidities, clinical interventions, and treatment of MDD have been identified as hot topics, while biological mechanisms in MDD are likely to be an emerging research priority.

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The Meta-Analysis in Evidence-Based Medicine: High-Quality Research When Properly Performed

Cited by 2 publications

References 22 publications

Reconsidering evidence-based management of endometriosis

Reconsidering evidence-based management of endometriosis

Systematic reviews and meta-analyses on major depressive disorder: a bibliometric perspective

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