The mesenchymal stem cell profile in psoriasis

Orciani, Monia; Campanati, Anna; Salvolini, Eleonora; Lucarini, Guendalina; Benedetto, Giovanni Di; Offidani, Annamaria; Primio, Roberto Di

doi:10.1111/j.1365-2133.2011.10438.x

Cited by 75 publications

(77 citation statements)

References 32 publications

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“…Mesenchymal stem cells were isolated from each skin specimen, maintaining the same features detected in our previous works [3,31].…”

Section: Isolation Culture and Characterization Of Mscsmentioning

confidence: 99%

“…The increasing focus on MSCs is due to the recent evidences on their possible involvement in different pathologies [32,36]. It has already been demonstrated that the altered microenvironment in psoriatic skin may induce the resident MSCs to produce angiogenic and pro-inflammatory mediators (VEGF, iNOS) leading to a reduction in the antioxidant ability of these cells, thus contributing to the pathophysiology of psoriasis [3,31]. In this view, we wonder if psoriasis could be considered a disease whose development starts early, in resident MSCs, which could show a typical phenotype, probably committed to develop psoriasis.…”

Section: Introductionmentioning

confidence: 99%

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Characterization and profiling of immunomodulatory genes in resident mesenchymal stem cells reflect the Th1-Th17/Th2 imbalance of psoriasis

et al. 2014

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The expression of genes encoding for Th1, Th2 and Th17 cytokines has been extensively evaluated in differentiated skin cells of psoriatic patients. The microenvironment exerts a control on the phenotype of resident mesenchymal stem cells (MSCs) into the skin of psoriasis patients. Aim of the study was to extensively evaluate the relative expression of 43 genes encoding for Th1, Th2 and Th17 cytokines in MSCs isolated from skin of psoriasis patients. MSCs resident into psoriatic skin were isolated, characterized and profiled by PCR array for the relative expression of genes encoding for cytokines involved in Th1, Th2 and Th17 pathways. MSCs isolated from the skin of healthy subjects were used as control. The MSCs isolated from skin of psoriasis patients showed a greater relative expression of the most part of the analyzed genes encoding for Th1 and Th17 cytokines: INF-γ, CCR5, CXCL9, CXCL10, IL6, IL8, TNF-α, IL23A, CCL2, CCL20, CXCL2, CXCL5, IL17C, IL17F, IL17RA, IL21, TLR2 than healthy subjects. On the contrary, the relative expression of genes encoding for Th2 cytokines: CCL1, CCL22, CXCL12, IL2, IL3, IL4, IL13B, IL 22, IL 27, TGF-β1, was similar between the MSCs isolated from psoriasis and healthy subjects. In conclusion, the MSCs isolated from psoriasis show an imbalance between the Th1-Th17 and Th2 pathways, which reflects the well-known abnormal balance observed in differentiated skin cells. This evidence could strengthen the hypothesis of an early involvement of resident MSCs in the pathogenesis of psoriasis.

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“…Mesenchymal stem cells were isolated from each skin specimen, maintaining the same features detected in our previous works [3,31].…”

Section: Isolation Culture and Characterization Of Mscsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Characterization and profiling of immunomodulatory genes in resident mesenchymal stem cells reflect the Th1-Th17/Th2 imbalance of psoriasis

et al. 2014

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“…Psoriatic cutaneous lesions are promoted and sustained by T-cell and neutrophil infiltration into both dermis and epidermis, which leads to inflammation, causing a reduction of global antioxidant capacity of the skin. It has been suggested that increased reactive oxygen species (ROS) production and an aberrant antioxidant system may be the main factors in pathogenesis of psoriasis (6,17,38,57). ROS actively promote the secretion of inflammatory Th1 cytokines…”

mentioning

confidence: 99%

Effects of Human Mesenchymal Stem Cells Transduced with Superoxide Dismutase on Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice

Sah

Kim

Yun

et al. 2016

Antioxidants & Redox Signaling

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Aims: The immunomodulatory and anti-inflammatory properties of mesenchymal stem cells (MSCs) have been proposed in several autoimmune diseases and successfully tested in animal models, but their contribution to psoriasis and underlying pathways remains elusive. Likewise, an increased or prolonged presence of reactive oxygen species and aberrant antioxidant systems in skin are known to contribute to the development of psoriasis and therefore effective antioxidant therapy is highly required. We explored the feasibility of using extracellular superoxide dismutase (SOD3)-transduced allogeneic MSCs as a novel therapeutic approach in a mouse model of imiquimod (IMQ)-induced psoriasis-like inflammation and investigated the poorly understood underlying mechanism. In addition, the chronicity and late-phase response of inflammation were evaluated during continued activation of antigen receptors by applying a booster dose of IMQ. Results: Subcutaneous injection of allogeneic SOD3-transduced MSCs significantly prevented psoriasis development in our IMQ-induced mouse model, likely through a suppression of proliferation and infiltration of various effector cells into skin with a concomitant modulated cytokine and chemokine expression and inhibition of signaling pathways such as tolllike receptor-7, nuclear factor-kappa B, p38 mitogen-activated kinase, and Janus kinase-signal transducer and activator of transcription, as well as adenosine receptor activation. Innovation and Conclusion: Our data offer a novel therapeutic approach to chronic inflammatory skin diseases such as psoriasis by leveraging immunomodulatory effects of MSCs as well as SOD3 expression. Antioxid. Redox Signal. 24, 233-248.

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“…This discrepancy has been already described in a variety of models including also antimicrobial effector function [41] or in other cell types such as macrophages [42]. However, human skin-derived MSC seem able to produce NO especially when analysed in subject with psoriasis [43].…”

Section: Msc Immunosuppressive Properties In Vivomentioning

confidence: 91%

Therapeutic immunomodulation with mesenchymal stromal cells: the need for in vivo clues

Dolcetti

Dazzi

2015

IJTS

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Mesenchymal stem/stromal cells are effective therapeutic agents for a variety of pathological conditions. However, the molecular mechanisms underlying their action remain largely unknown and biased by in vitro studies. In this concise review we have described recent advances in MSC therapeutics based on in vivo observations. We have also discussed the possibility of using engineering approaches to improve and facilitate deciphering MSC functions.

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The mesenchymal stem cell profile in psoriasis

Cited by 75 publications

References 32 publications

Characterization and profiling of immunomodulatory genes in resident mesenchymal stem cells reflect the Th1-Th17/Th2 imbalance of psoriasis

Characterization and profiling of immunomodulatory genes in resident mesenchymal stem cells reflect the Th1-Th17/Th2 imbalance of psoriasis

Effects of Human Mesenchymal Stem Cells Transduced with Superoxide Dismutase on Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice

Therapeutic immunomodulation with mesenchymal stromal cells: the need for in vivo clues

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