The mesencephalic locomotor region (MLR) in the rat

Skinner, R.D.; García‐Rill, Edgar

doi:10.1016/0006-8993(84)90319-6

Cited by 254 publications

(156 citation statements)

References 7 publications

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“…Inglis & Winn, 1995;Semba & Fibiger, 1992). The case is such that it has been proposed that this area could correspond to the mesencephalic locomotor region (García-Rill, 1986;Skinner & García-Rill, 1984). The results obtained in this second experiment can be compared with those of earlier studies (Swerdlow & Geyer, 1993;Podhorna & Franklin, 1998) that rule out the possibility that the lesions caused the animals any serious motor impairment.…”

Section: Figsupporting

confidence: 49%

Section: Methodsmentioning

confidence: 99%

“…In fact, García-Rill refers to it as the "mesencephalic locomotor region" (Skinner & García-Rill, 1984). It has been shown that electrical stimulation of the region causes locomotion (Skinner & García-Rill, 1984) and that the cholinergic neurons of the PPN innervate the basal ganglia (the connection is reciprocal) and the thalamus (Grunwerg, Krein, & Krauthamer, 1992;Inglis & Winn, 1995). In fact, it has been proposed that damage to the PPN could explain some of the motor expressions of Parkinson's Disease (García-Rill, 1986) and that lesions in this tegmental region could serve as a good animal model for the disease (Dunbar, Hitchcock, Latimer, Rugg, Ward, & Winn, 1992).…”

Section: Methodsmentioning

confidence: 99%

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Electrolytic Lesions of the Pedunculopontine Nucleus Disrupt Concurrent Learned Aversion Induced by NaCl

Mediavilla

Molina

Puerto

2000

Neurobiology of Learning and Memory

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Bilateral electrolytic lesions in the pedunculopontine nucleus (PPN) impair acquisition of short-term, or concurrent, Taste Aversion Learning (TAL) in rats. This type of TAL is characterized by the daily presentation of two different flavor stimuli at the same time, one associated with simultaneous intragastric administration of an aversive product (hypertonic NaCl) and the other with physiological saline. Sham-lesioned control animals learn this taste discrimination task, but both lesioned animals and control animals learn a long-term, or delayed, TAL task in which each gustatory stimulus is presented individually every other day and the intragastric products, LiCl (0.15 M) and physiological saline, are administered after a 15-min delay. These results are analyzed in the context of the cerebellar circuits involved in learning and in relation to the two TAL modalities described above. ᭧ 2000 Academic Press

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Section: Figsupporting

confidence: 49%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Electrolytic Lesions of the Pedunculopontine Nucleus Disrupt Concurrent Learned Aversion Induced by NaCl

Mediavilla

Molina

Puerto

2000

Neurobiology of Learning and Memory

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“…A similar setup has been also successful adopted in other studies [36,186]. In animal studies a similar frequency has been proved to be effective in inducing locomotion [181,187]. However, in a recent animal study locomotion was best achieved at 10-20 Hz [171], i.e.…”

Section: Resultsmentioning

confidence: 96%

“…With regard to the motor nature of the PPTg, this is supported by the PPTg being part of most of the mesencephalic locomotor region, by its connections with subcortical and cortical motor structures, by its fibers innervating lower brainstem and reticulospinal neurons, by its activation in locomotor imagery tasks, by its neurons that discharge in relation to limb movements and, finally, by improvements of motor disabilities induced by its continuous electrical stimulation in PD patients [29,[33][34][35]169,[179][180][181][182][183][184].…”

Section: Resultsmentioning

confidence: 99%

Participation of the pedunculopontine tegmental nucleus in arousal-demanding functions

Vitale¹,

Capozzo²,

Mazzone³

et al. 2017

Transl Brain Rhythmicity

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The pedunculopontine tegmental nucleus (PPTg) is part of the locomotor mesencephalic region and the reticular activating system (RAS). As such, it is involved in regulating some aspects of the motor control and the wake/sleep cycle, but the way in which it operates is unclear. PPTg neurons respond to a variety of sensory stimuli and to cues that trigger the execution of goal-directed motor acts. In this paper, we discuss data that suggest that in addition to operating via thalamic nuclei, the PPTg may also operate by activating cerebellar nuclei, especially the dentate nucleus. In such a way, an intense and diffuse activation of the cerebral cortex may be achieved. In arousal-demanding reward-related tasks, separate populations of PPTg neurons modulate their discharge pattern to encode, in particular, expectancy and magnitude of reward. These neuronal responses, which should reach thalamic, basal ganglia, and cerebellar nuclei through ascending PPTg fibers are essential for the formation of stimuli-reward associations and action selection. In parallel, PPTg neurons, via descending fibers directed to lower brainstem and spinal motor structures, may automatically influence motor mechanisms and muscle tone in order to cause movements that are executed in a smooth and timely manner. In patients affected by Parkinson's disease, PPTg deep brain stimulation may increase arousal, thus making patients more attentive to behavioral stimuli that trigger motor act, while simultaneously facilitating movement.

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Stimulation of the mesencephalic locomotor region for gait recovery after stroke

Malzahn

Homola

Schuhmann

et al. 2017

Annals of Neurology

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The mesencephalic locomotor region (MLR) in the rat

Cited by 254 publications

References 7 publications

Electrolytic Lesions of the Pedunculopontine Nucleus Disrupt Concurrent Learned Aversion Induced by NaCl

Electrolytic Lesions of the Pedunculopontine Nucleus Disrupt Concurrent Learned Aversion Induced by NaCl

Participation of the pedunculopontine tegmental nucleus in arousal-demanding functions

Stimulation of the mesencephalic locomotor region for gait recovery after stroke

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