The Menstrual Cycle CONCENTRATION OF UNCONJUGATED ESTRONE AND ESTRADIOL IN PERIPHERAL PLASMA IN NONPREGNANT WOMEN THROUGHOUT THE MENSTRUAL CYCLE, CASTRATE AND POSTMENOPAUSAL WOMEN AND IN MEN

Baird, D. T.; Guevara, Amelia

doi:10.1097/00006254-196909000-00016

Cited by 26 publications

(34 citation statements)

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“…The plasma clearance of oestrone sulphate was similar to values found by us in a previous investigation (L0nm 'ng et al, 1987), the oestrone sulphate production rate was found somewhat lower than values reported for young men and menstruating women in the follicular phase of cyclus (Longcope, 1972;Ruder et al, 1972 (Noel et al, 1979). One study has suggested a diurnal variation of oestrone in men (Baird & Guevara, 1969 (Longcope, 1972;Ruder et al, 1972). In this study we found aminoglutethimide treatment to depress plasma oestrone and oestrone sulphate to about 55% and 30% of their control levels.…”

Section: Pharmacokinetic Calculationssupporting

confidence: 51%

Alterations in the production rate and the metabolism of oestrone and oestrone sulphate in breast cancer patients treated with aminoglutethimide

Lønning

Johannessen²,

Thorsen³

1989

Br J Cancer

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Section: Pharmacokinetic Calculationssupporting

confidence: 51%

Alterations in the production rate and the metabolism of oestrone and oestrone sulphate in breast cancer patients treated with aminoglutethimide

Lønning

Johannessen²,

Thorsen³

1989

Br J Cancer

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“…Specificity of the uterine receptor for estrogens has been demonstrated (13,17). Comparability of estrogen measurements with those of Baird and Guevara, using a double isotope derivative procedure (18), has supported the validity of radioligand assay.…”

Section: Methodsmentioning

confidence: 83%

The plasma estradiol as an index of fetoplacental function

Tulchinsky¹,

Korenman²

1971

J. Clin. Invest.

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A B S T R A C T A radioligand assay has been developedfor the measurement of unconjugated 17j#-estradiol in as little as 0.01 ml of pregnancy plasma employing rabbit uterine cytosol as specific binder and activated charcoal as nonspecific adsorbant. Large numbers of samples could be processed simultaneously at relatively little expense and results were obtainable within 3 hr. The procedure was sensitive to 1 ng/ml. No diurnal or positional variations were found. Values from 250 unselected normal patients showed a constantly rising mean plasma E2 from 18 to 35 wk gestation from 4.5 to 14 ng/ml. From 35 to 40 wk, mean E2 rose only to 15 ng/ml and the range of values increased substantially. When 22 normal pregnant subjects were followed serially, rising levels of plasma E2 were found with no significant fall ever seen. By contrast, patients exhibiting fetal distress generally had falling or reduced E2 levels. However, 3 cases of Rh isoimmunization had elevated or normal E2 concentrations even after clearcut evidence of fetal demise. A decrease of 45% in E2 concentration was associated with intraamniotic instillation of hypertonic saline prior to delivery supporting the view that placental conversion of maternal adrenal precursors is responsible for about half of the Ea production in pregnancy. The postpartum clearance of endogenous E2 was measured and found to fit a two compartment model with mean half-time of 22 min and 7 hr. Follicular phase levels of E2 were attained by 35 hr postpartum. The concentration of unconjugated E2 in pregnancy plasma correlated as well with the state of the placenta as other placental hormone measurements and holds promise of being a rapid, inexpensive, and reliable method of following patients with high-risk pregnancies in a variety of clinical settings.

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“…The consistent finding that estrogen production rates, calculated from dilution of labeled estrogen into urinary metabolites, are smaller than those calculated from the MCR and plasma concentration is further evidence that the latter method overestimates the production rate. Next, the known diurnal variations in plasma estrone concentration (27,28) and possibly of estradiol, mean that production rates obtained using morning plasma estrogen concentrations will systematically overestimate the 24 hr estrogen production rate of these unconjugated estrogens. Finally, since plasma estradiol and estrone have plasma turnovers of about 50 pools/day and E1S turnover rate is 3.3 pools/day, plasma concentrations of E1S will lag behind plasma estrone and estradiol by 6-12 hr.…”

Section: Conversion Of Es To Es the Data Obtained Frommentioning

confidence: 99%

Estrone Sulfate: Production Rate and Metabolism in Man

Ruder¹,

Loriaux²,

Lipsett³

1972

J. Clin. Invest.

246

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A B S T R A C T Since estrone sulfate (E1S) is present at high concentration in plasma, we have examined the parameters of the plasma estrone, estradiol, E1S system. The metabolic clearance rate of EiS was 157 liter/day (range 70-292) in men and women. Estimated plasma production rates of E1S were (/Agrams per day): men, 77; women, early follicular phase, 95; women, early luteal phase, 182. The conversion of plasma estrone and estradiol to EiS was measured and from these data and the metabolic clearance rates of the estrogens, the transfer factors were p51'18 = 0.54 and p'2'1' = 0.65. Using average production rates, all plasma E1S could be shown to be derived from plasma estrone and estradiol.The conversion of plasma E1S to plasma estrone and estradiol was studied. The calculated transfer factors were: p'1`81 = 0.21, pBis2 = 0.014. Essentially, similar data were obtained when E1S was given by mouth to two subjects.We conclude: (a) EiS is a major circulating plasma estrogen and has a long plasma half-life; (b) the large contributions of estrone and estradiol to plasma E1S are more than sufficient to account for all the circulating plasma E1S.

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The Menstrual Cycle CONCENTRATION OF UNCONJUGATED ESTRONE AND ESTRADIOL IN PERIPHERAL PLASMA IN NONPREGNANT WOMEN THROUGHOUT THE MENSTRUAL CYCLE, CASTRATE AND POSTMENOPAUSAL WOMEN AND IN MEN

Cited by 26 publications

References 0 publications

Alterations in the production rate and the metabolism of oestrone and oestrone sulphate in breast cancer patients treated with aminoglutethimide

Alterations in the production rate and the metabolism of oestrone and oestrone sulphate in breast cancer patients treated with aminoglutethimide

The plasma estradiol as an index of fetoplacental function

Estrone Sulfate: Production Rate and Metabolism in Man

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