The Memory Binding Test: Development of Two Alternate Forms into Spanish and Catalan

Gramunt, Nina; Sánchez‐Benavides, Gonzalo; Buschke, Herman; Diéguez-Vide, Faustino; Peña-Casanova, Jordi; Masramon, Xavier; Fauria, Karine; Gispert, Juan Domingo; Molinuevo, José Luís

doi:10.3233/jad-151175

Cited by 27 publications

(18 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The neuropsychological assessment took place on average 10.6 months (SD = 5.81) before the MRI session. EM was assessed using the Spanish adapted version of the Memory Binding Test (MBT) (Gramunt et al, 2016), an instrument that was developed for detecting subtle memory impairment in the cognitively intact population (Buschke, 2014). Previous studies have demonstrated the ability of the MBT (formerly referred as Memory Capacity Test [MCT]) to discriminate subjects with cerebral Aβ deposition (Papp et al, 2015), and to successfully predict the incidence of MCI longitudinally (Mowrey et al, 2016).…”

Section: Methodsmentioning

confidence: 99%

APOE-ε4 risk variant for Alzheimer's disease modifies the association between cognitive performance and cerebral morphology in healthy middle-aged individuals

Cacciaglia

Molinuevo

Falcón

et al. 2019

NeuroImage: Clinical

Self Cite

View full text Add to dashboard Cite

The APOE -ε4 genotype is the highest genetic risk factor for Alzheimer's disease (AD). In cognitively unimpaired individuals, it has been related to altered brain morphology, function and earlier amyloid beta accumulation. However, its impact on cognitive performance is less evident. Here, we examine the impact of APOE -ε4 allele load in modulating the association between cognitive functioning and brain morphology in middle-aged healthy individuals. A high-resolution structural MRI scan was acquired and episodic memory (EM) as well as executive functions (EFs) were assessed in a sample of 527 middle-aged unimpaired individuals hosting a substantial representation of ε4-homozygous ( N = 64). We adopted a voxel-wise unbiased method to assess whether the number of APOE -ε4 alleles significantly modified the associations between gray matter volumes (GMv) and performance in both cognitive domains. Even though the APOE -ε4 allele load did not exert a direct impact on any cognitive measures, it reversed the relationships between GMv and cognitive performance in a highly symmetrical topological pattern. For EM, interactions mapped onto the inferior temporal gyrus and the dorsal anterior cingulate cortex. Regarding EFs, significant interactions were observed for processing speed, working memory, and visuospatial attention in distinct brain regions. These results suggest that APOE -ε4 carriers display a structure-function association corresponding to an older age than their chronological one. Our findings additionally indicate that APOE -ε4 carriers may rely on the integrity of multiple compensatory brain systems in order to preserve their cognitive abilities, possibly due to an incipient neurodegeneration. Overall this study provides novel insights on the mechanisms through which APOE -ε4 posits an increased AD risk.

show abstract

Section: Methodsmentioning

confidence: 99%

APOE-ε4 risk variant for Alzheimer's disease modifies the association between cognitive performance and cerebral morphology in healthy middle-aged individuals

Cacciaglia

Molinuevo

Falcón

et al. 2019

NeuroImage: Clinical

Self Cite

View full text Add to dashboard Cite

show abstract

“…Free, cued, and paired recall are assessed in immediate and delayed (after 25–35 min) trials. We used the Spanish version of the MBT that we have recently adapted, normed, and validated [34]. The following main variables were gathered and analyzed: immediate total paired recall (TPR), immediate total free recall (TFR), total delayed paired recall (TDPR), and total delayed free recall (TDFR).…”

Section: Methodsmentioning

confidence: 99%

Brain and cognitive correlates of subjective cognitive decline-plus features in a population-based cohort

Sánchez‐Benavides

Grau‐Rivera²,

Suárez‐Calvet

et al. 2018

Alz Res Therapy

Self Cite

View full text Add to dashboard Cite

BackgroundSubjective cognitive decline (SCD) consists of self-perceived decline in cognition over time. The occurrence of specific additional features in SCD (so-called SCDplus) confers a higher risk of future cognitive decline. However, it is not known whether SCDplus patients have a distinct cognitive and neuroimaging profile. Therefore, we aimed to study the associations between SCDplus features and cognitive and neuroimaging profiles in a population-based cohort.MethodsA total of 2670 individuals from the ALFA cohort underwent clinical, cognitive, and MRI (n = 532) explorations. Subjects were classified as self-reporting cognitive decline (SCD) or not self-reporting cognitive decline (non-SCD). Within the SCD group, participants were also classified according to the number of SCDplus features they met (SCD+, > 3; SCD–, ≤ 3).ResultsThe prevalence of SCD in the cohort was 21.4% (55.8% SCD–, 44.2% SCD+). SCD+ subjects performed worse than non-SCD and SCD– subjects in memory and executive function. Among the SCDplus features, confirmation of decline by an informant was the best predictor of worse cognitive performance and lower gray matter volumes.ConclusionsOur findings show that individuals with SCDplus features have a distinct cognitive and brain volumetric profile similar to that found in Alzheimer’s disease and therefore support the use of the SCDplus concept as an enrichment criterion in population-based cohorts.Electronic supplementary materialThe online version of this article (10.1186/s13195-018-0449-9) contains supplementary material, which is available to authorized users.

show abstract

“…Spanish translation and transcultural adaptation of the MBT. Although there is a Spanish version of the MBT for Spain 44 - 46 and another for Colombia, 47 some words are infrequent in Argentina (zumo, laton, taburete, alicates, ensaimada, aspirador, colgantes, vitrina, cipres, among others). These could have affected the Encoding Specificity and Binding, two important aspects of the MBT.…”

Section: Methodsmentioning

confidence: 99%

Validation of the Argentine version of the Memory Binding Test (MBT) for Early Detection of Mild Cognitive Impairment

Román¹,

Iturry²,

Rojas³

et al. 2016

Dement. neuropsychol.

Self Cite

View full text Add to dashboard Cite

Background: "Forgetfulness" is frequent in normal aging and characteristic of the early stages of dementia syndromes. The episodic memory test is central for detecting amnestic mild cognitive impairment (MCI). The Memory Binding Test (MBT) is a simple, easy and brief memory test to detect the early stage of episodic memory impairment. Objective: To validate the Argentine version of the MBT in a Latin American population and to estimate the diagnostic accuracy as a tool for early detection of MCI. Methods: 88 subjects (46 healthy controls and 42 patients with amnestic MCI) matched for age and educational level were evaluated by an extensive neuropsychological battery and the memory binding test. Results: A significantly better performance was detected in the control group; all MBT scales were predictive of MCI diagnosis (p<.01). The MBT showed high sensitivity (69%) and high specificity (88%), with a PPV of 93% and a NPV of 55% for associative paired recall. A statistically significant difference (c2=14,164, p<.001) was obtained when comparing the area under the curve (AUC) of the MBT (0.88) and the MMSE (0.70). Conclusion: The Argentine version of the MBT correlated significantly with the MMSE and the memory battery and is a useful tool in the detection of MCI. The operating characteristics of the MBT are well suited, surpassing other tests commonly used for detecting MCI.

show abstract

The Memory Binding Test: Development of Two Alternate Forms into Spanish and Catalan

Abstract: The MBT A and B in Spanish and Catalan showed similar outcomes and can be considered equivalent. Moreover, the thorough methodology presented here for the transcultural adaptation and equivalence study, could serve as a model for future adaptations of the MBT and other verbal tests.

Cited by 27 publications

References 28 publications

APOE-ε4 risk variant for Alzheimer's disease modifies the association between cognitive performance and cerebral morphology in healthy middle-aged individuals

APOE-ε4 risk variant for Alzheimer's disease modifies the association between cognitive performance and cerebral morphology in healthy middle-aged individuals

Brain and cognitive correlates of subjective cognitive decline-plus features in a population-based cohort

Validation of the Argentine version of the Memory Binding Test (MBT) for Early Detection of Mild Cognitive Impairment

Contact Info

Product

Resources

About